Gross tumour delineation on computed tomography and positron emission tomography-computed tomography in oesophageal cancer: A nationwide study

M. E. Nowee; F. E. M. Voncken; A. N. T. J. Kotte; L. Goense; P. S. N. van Rossum; A. L. H. M. W. van Lier; S. W. Heijmink; B. M. P. Aleman; J. Nijkamp; G. J. Meijer; I. M. Lips; P. M. Braam; J. Buijsen; H. M. Ceha; L. Dewit; J. H. Franssen; K. van Gestel; D. A. R. H. Grootenboers; M. Intven; E. P. M. Jansen; L. G. W. Kerkmeijer; V. E. Mul; K. Muller; K. J. Neelis; V Oppedijk; T. Rozema; P. H. Spruit

doi:10.1016/j.ctro.2018.10.003

Gross tumour delineation on computed tomography and positron emission tomography-computed tomography in oesophageal cancer: A nationwide study

M. E. Nowee, F. E. M. Voncken, A. N. T. J. Kotte, L. Goense, P. S. N. van Rossum, A. L. H. M. W. van Lier, S. W. Heijmink, B. M. P. Aleman, J. Nijkamp, G. J. Meijer, I. M. Lips, P. M. Braam, J. Buijsen, H. M. Ceha, L. Dewit, J. H. Franssen, K. van Gestel, D. A. R. H. Grootenboers, M. Intven, E. P. M. JansenL. G. W. Kerkmeijer, V. E. Mul, K. Muller, K. J. Neelis, V Oppedijk, T. Rozema, P. H. Spruit

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Abstract

Background and purpose: Accurate delineation of the primary tumour is vital to the success of radiotherapy and even more important for successful boost strategies, aiming for improved local control in oesophageal cancer patients. Therefore, the aim was to assess delineation variability of the gross tumour volume (GTV) between CT and combined PET-CT in oesophageal cancer patients in a multi-institutional study. Materials and methods: Twenty observers from 14 institutes delineated the primary tumour of 6 cases on CT and PET-CT fusion. The delineated volumes, generalized conformity index (CIgen) and standard deviation (SD) in position of the most cranial/caudal slice over the observers were evaluated. For the central delineated region, perpendicular distance between median surface GTV and each individual GTV was evaluated as in-slice SD. Results: After addition of PET, mean GTVs were significantly smaller in 3 cases and larger in 1 case. No difference in CIgen was observed (average 0.67 on CT, 0.69 on PET-CT). On CT cranial-caudal delineation variation ranged between 0.2 and 1.5 cm SD versus 0.2 and 1.3 cm SD on PET-CT. After addition of PET, the cranial and caudal variation was significantly reduced in 1 and 2 cases, respectively. The in-slice SD was on average 0.16 cm in both phases. Conclusion: In some cases considerable GTV delineation variability was observed at the cranial-caudal border. PET significantly influenced the delineated volume in four out of six cases, however its impact on observer variation was limited.

Original language	English
Pages (from-to)	33-39
Number of pages	7
Journal	Clinical and translational radiation oncology
Volume	14
DOIs	https://doi.org/10.1016/j.ctro.2018.10.003
Publication status	Published - Jan 2019

Keywords

Oesophageal cancer
GTV delineation
Interobserver variability
FDG-PET/CT
Chemoradiotherapy

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10.1016/j.ctro.2018.10.003

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Nowee, M. E., Voncken, F. E. M., Kotte, A. N. T. J., Goense, L., van Rossum, P. S. N., van Lier, A. L. H. M. W., Heijmink, S. W., Aleman, B. M. P., Nijkamp, J., Meijer, G. J., Lips, I. M., Braam, P. M., Buijsen, J., Ceha, H. M., Dewit, L., Franssen, J. H., van Gestel, K., Grootenboers, D. A. R. H., Intven, M., ... Spruit, P. H. (2019). Gross tumour delineation on computed tomography and positron emission tomography-computed tomography in oesophageal cancer: A nationwide study. Clinical and translational radiation oncology, 14, 33-39. https://doi.org/10.1016/j.ctro.2018.10.003

@article{e31b115ac32544df87312aa27b18d7cd,

title = "Gross tumour delineation on computed tomography and positron emission tomography-computed tomography in oesophageal cancer: A nationwide study",

abstract = "Background and purpose: Accurate delineation of the primary tumour is vital to the success of radiotherapy and even more important for successful boost strategies, aiming for improved local control in oesophageal cancer patients. Therefore, the aim was to assess delineation variability of the gross tumour volume (GTV) between CT and combined PET-CT in oesophageal cancer patients in a multi-institutional study. Materials and methods: Twenty observers from 14 institutes delineated the primary tumour of 6 cases on CT and PET-CT fusion. The delineated volumes, generalized conformity index (CIgen) and standard deviation (SD) in position of the most cranial/caudal slice over the observers were evaluated. For the central delineated region, perpendicular distance between median surface GTV and each individual GTV was evaluated as in-slice SD. Results: After addition of PET, mean GTVs were significantly smaller in 3 cases and larger in 1 case. No difference in CIgen was observed (average 0.67 on CT, 0.69 on PET-CT). On CT cranial-caudal delineation variation ranged between 0.2 and 1.5 cm SD versus 0.2 and 1.3 cm SD on PET-CT. After addition of PET, the cranial and caudal variation was significantly reduced in 1 and 2 cases, respectively. The in-slice SD was on average 0.16 cm in both phases. Conclusion: In some cases considerable GTV delineation variability was observed at the cranial-caudal border. PET significantly influenced the delineated volume in four out of six cases, however its impact on observer variation was limited.",

keywords = "Oesophageal cancer, GTV delineation, Interobserver variability, FDG-PET/CT, Chemoradiotherapy",

author = "Nowee, {M. E.} and Voncken, {F. E. M.} and Kotte, {A. N. T. J.} and L. Goense and {van Rossum}, {P. S. N.} and {van Lier}, {A. L. H. M. W.} and Heijmink, {S. W.} and Aleman, {B. M. P.} and J. Nijkamp and Meijer, {G. J.} and Lips, {I. M.} and Braam, {P. M.} and J. Buijsen and Ceha, {H. M.} and L. Dewit and Franssen, {J. H.} and {van Gestel}, K. and Grootenboers, {D. A. R. H.} and M. Intven and Jansen, {E. P. M.} and Kerkmeijer, {L. G. W.} and Mul, {V. E.} and K. Muller and Neelis, {K. J.} and V Oppedijk and T. Rozema and Spruit, {P. H.}",

note = "Publisher Copyright: {\textcopyright} 2018 The Authors",

year = "2019",

month = jan,

doi = "10.1016/j.ctro.2018.10.003",

language = "English",

volume = "14",

pages = "33--39",

}

Nowee, ME, Voncken, FEM, Kotte, ANTJ, Goense, L, van Rossum, PSN, van Lier, ALHMW, Heijmink, SW, Aleman, BMP, Nijkamp, J, Meijer, GJ, Lips, IM, Braam, PM, Buijsen, J, Ceha, HM, Dewit, L, Franssen, JH, van Gestel, K, Grootenboers, DARH, Intven, M, Jansen, EPM, Kerkmeijer, LGW, Mul, VE, Muller, K, Neelis, KJ, Oppedijk, V, Rozema, T & Spruit, PH 2019, 'Gross tumour delineation on computed tomography and positron emission tomography-computed tomography in oesophageal cancer: A nationwide study', Clinical and translational radiation oncology, vol. 14, pp. 33-39. https://doi.org/10.1016/j.ctro.2018.10.003

TY - JOUR

T1 - Gross tumour delineation on computed tomography and positron emission tomography-computed tomography in oesophageal cancer

T2 - A nationwide study

AU - Nowee, M. E.

AU - Voncken, F. E. M.

AU - Kotte, A. N. T. J.

AU - Goense, L.

AU - van Rossum, P. S. N.

AU - van Lier, A. L. H. M. W.

AU - Heijmink, S. W.

AU - Aleman, B. M. P.

AU - Nijkamp, J.

AU - Meijer, G. J.

AU - Lips, I. M.

AU - Braam, P. M.

AU - Buijsen, J.

AU - Ceha, H. M.

AU - Dewit, L.

AU - Franssen, J. H.

AU - van Gestel, K.

AU - Grootenboers, D. A. R. H.

AU - Intven, M.

AU - Jansen, E. P. M.

AU - Kerkmeijer, L. G. W.

AU - Mul, V. E.

AU - Muller, K.

AU - Neelis, K. J.

AU - Oppedijk, V

AU - Rozema, T.

AU - Spruit, P. H.

PY - 2019/1

Y1 - 2019/1

N2 - Background and purpose: Accurate delineation of the primary tumour is vital to the success of radiotherapy and even more important for successful boost strategies, aiming for improved local control in oesophageal cancer patients. Therefore, the aim was to assess delineation variability of the gross tumour volume (GTV) between CT and combined PET-CT in oesophageal cancer patients in a multi-institutional study. Materials and methods: Twenty observers from 14 institutes delineated the primary tumour of 6 cases on CT and PET-CT fusion. The delineated volumes, generalized conformity index (CIgen) and standard deviation (SD) in position of the most cranial/caudal slice over the observers were evaluated. For the central delineated region, perpendicular distance between median surface GTV and each individual GTV was evaluated as in-slice SD. Results: After addition of PET, mean GTVs were significantly smaller in 3 cases and larger in 1 case. No difference in CIgen was observed (average 0.67 on CT, 0.69 on PET-CT). On CT cranial-caudal delineation variation ranged between 0.2 and 1.5 cm SD versus 0.2 and 1.3 cm SD on PET-CT. After addition of PET, the cranial and caudal variation was significantly reduced in 1 and 2 cases, respectively. The in-slice SD was on average 0.16 cm in both phases. Conclusion: In some cases considerable GTV delineation variability was observed at the cranial-caudal border. PET significantly influenced the delineated volume in four out of six cases, however its impact on observer variation was limited.

AB - Background and purpose: Accurate delineation of the primary tumour is vital to the success of radiotherapy and even more important for successful boost strategies, aiming for improved local control in oesophageal cancer patients. Therefore, the aim was to assess delineation variability of the gross tumour volume (GTV) between CT and combined PET-CT in oesophageal cancer patients in a multi-institutional study. Materials and methods: Twenty observers from 14 institutes delineated the primary tumour of 6 cases on CT and PET-CT fusion. The delineated volumes, generalized conformity index (CIgen) and standard deviation (SD) in position of the most cranial/caudal slice over the observers were evaluated. For the central delineated region, perpendicular distance between median surface GTV and each individual GTV was evaluated as in-slice SD. Results: After addition of PET, mean GTVs were significantly smaller in 3 cases and larger in 1 case. No difference in CIgen was observed (average 0.67 on CT, 0.69 on PET-CT). On CT cranial-caudal delineation variation ranged between 0.2 and 1.5 cm SD versus 0.2 and 1.3 cm SD on PET-CT. After addition of PET, the cranial and caudal variation was significantly reduced in 1 and 2 cases, respectively. The in-slice SD was on average 0.16 cm in both phases. Conclusion: In some cases considerable GTV delineation variability was observed at the cranial-caudal border. PET significantly influenced the delineated volume in four out of six cases, however its impact on observer variation was limited.

KW - Oesophageal cancer

KW - GTV delineation

KW - Interobserver variability

KW - FDG-PET/CT

KW - Chemoradiotherapy

UR - http://www.scopus.com/inward/record.url?scp=85066330214&partnerID=8YFLogxK

U2 - 10.1016/j.ctro.2018.10.003

DO - 10.1016/j.ctro.2018.10.003

M3 - Article

C2 - 30519647

SN - 2405-6308

VL - 14

SP - 33

EP - 39

JO - Clinical and translational radiation oncology

JF - Clinical and translational radiation oncology

ER -

Gross tumour delineation on computed tomography and positron emission tomography-computed tomography in oesophageal cancer: A nationwide study

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Keywords

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