TY - JOUR
T1 - Granulosa cell tumor patients presenting with acute abdomen
T2 - a case series
AU - Brink, Geertruid J
AU - Groeneweg, Jolijn W
AU - Sickinghe, Ariane A
AU - Lok, Christianne A R
AU - Nijman, Hans W
AU - Piek, Jurgen M J
AU - Hofhuis, Ward
AU - Roes, Eva Maria
AU - van Lonkhuijzen, Luc R C W
AU - de Kroon, Cor D
AU - Gort, Eelke H
AU - Witteveen, Petronella O
AU - Zweemer, Ronald P
N1 - Publisher Copyright:
© 2025
PY - 2025/8
Y1 - 2025/8
N2 - OBJECTIVE: To highlight the unique clinical presentation of acute abdomen in granulosa cell tumor patients.METHODS: In a multicenter cohort study of adult-type granulosa cell tumors, women presenting with an acute abdomen at diagnosis were identified (Brink, 2025). After informed consent, clinical data were retrieved from patient records and collected in a Castor EDC database. Statistical analyses were performed to compare the subgroup of women with acute abdomen with the remainder of the adult type granulosa cell tumor cohort.RESULTS: Twenty-six out of 208 (12.5%) patients had an acute abdomen as presenting symptom of an adult-type granulosa cell tumor. All patients underwent emergency abdominal surgery. In 16 (62%) patients, the tumor mass was found to be ruptured pre-operatively, and 7 (27%) patients had an ovarian torsion. Seventeen patients (65%) of this group developed recurrent disease. When compared with the rest of the adult-type granulosa cell tumor cohort, patients with an acute abdomen at diagnosis were younger, had significantly more perioperative blood loss, and more often developed a recurrence.CONCLUSIONS: Adult-type granulosa cell tumors present with an acute abdomen in over 10% of the cases. In case of an ovarian mass or hemoperitoneum in women with an acute abdomen, a granulosa cell tumor should be considered in the differential diagnosis. Surgery can then be performed with a more oncological approach, striving to avoid spill and thus decrease the risk of recurrence.
AB - OBJECTIVE: To highlight the unique clinical presentation of acute abdomen in granulosa cell tumor patients.METHODS: In a multicenter cohort study of adult-type granulosa cell tumors, women presenting with an acute abdomen at diagnosis were identified (Brink, 2025). After informed consent, clinical data were retrieved from patient records and collected in a Castor EDC database. Statistical analyses were performed to compare the subgroup of women with acute abdomen with the remainder of the adult type granulosa cell tumor cohort.RESULTS: Twenty-six out of 208 (12.5%) patients had an acute abdomen as presenting symptom of an adult-type granulosa cell tumor. All patients underwent emergency abdominal surgery. In 16 (62%) patients, the tumor mass was found to be ruptured pre-operatively, and 7 (27%) patients had an ovarian torsion. Seventeen patients (65%) of this group developed recurrent disease. When compared with the rest of the adult-type granulosa cell tumor cohort, patients with an acute abdomen at diagnosis were younger, had significantly more perioperative blood loss, and more often developed a recurrence.CONCLUSIONS: Adult-type granulosa cell tumors present with an acute abdomen in over 10% of the cases. In case of an ovarian mass or hemoperitoneum in women with an acute abdomen, a granulosa cell tumor should be considered in the differential diagnosis. Surgery can then be performed with a more oncological approach, striving to avoid spill and thus decrease the risk of recurrence.
U2 - 10.1016/j.gore.2025.101781
DO - 10.1016/j.gore.2025.101781
M3 - Article
C2 - 40612387
SN - 2352-5789
VL - 60
JO - Gynecologic oncology reports
JF - Gynecologic oncology reports
M1 - 101781
ER -