Good and bad consequences of altered fatty acid metabolism in heart failure: Evidence from mouse models

Desiree Abdurrachim; Joost J F P Luiken; Klaas Nicolay; Jan F C Glatz; Jeanine J. Prompers; Miranda Nabben

doi:10.1093/cvr/cvv105

Good and bad consequences of altered fatty acid metabolism in heart failure: Evidence from mouse models

Desiree Abdurrachim, Joost J F P Luiken, Klaas Nicolay, Jan F C Glatz, Jeanine J. Prompers, Miranda Nabben^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

6 Citations (Scopus)

Abstract

The shift in substrate preference away from fatty acid oxidation (FAO) towards increased glucose utilization in heart failure has long been interpreted as an oxygen-sparing mechanism. Inhibition of FAO has therefore evolved as an accepted approach to treat heart failure. However, recent data indicate that increased reliance on glucose might be detrimental rather than beneficial for the failing heart. This review discusses new insights into metabolic adaptations in heart failure. A particular focus lies on data obtained from mouse models with modulations of cardiac FA metabolism at different levels of the FA metabolic pathway and how these differently affect cardiac function. Based on studies in which these mouse models were exposed to ischaemic and non-ischaemic heart failure, we discuss whether and when modulations in FA metabolism are protective against heart failure.

Original language	English
Pages (from-to)	194-205
Number of pages	12
Journal	Cardiovascular Research
Volume	106
Issue number	2
DOIs	https://doi.org/10.1093/cvr/cvv105
Publication status	Published - 1 May 2015
Externally published	Yes

Keywords

Energy metabolism
Genetically altered mice
Heart failure
Metabolic shift

Access to Document

10.1093/cvr/cvv105

Cite this

@article{f4fa7d6bd65a49ddb84a9df697aaa1a6,

title = "Good and bad consequences of altered fatty acid metabolism in heart failure: Evidence from mouse models",

abstract = "The shift in substrate preference away from fatty acid oxidation (FAO) towards increased glucose utilization in heart failure has long been interpreted as an oxygen-sparing mechanism. Inhibition of FAO has therefore evolved as an accepted approach to treat heart failure. However, recent data indicate that increased reliance on glucose might be detrimental rather than beneficial for the failing heart. This review discusses new insights into metabolic adaptations in heart failure. A particular focus lies on data obtained from mouse models with modulations of cardiac FA metabolism at different levels of the FA metabolic pathway and how these differently affect cardiac function. Based on studies in which these mouse models were exposed to ischaemic and non-ischaemic heart failure, we discuss whether and when modulations in FA metabolism are protective against heart failure.",

keywords = "Energy metabolism, Genetically altered mice, Heart failure, Metabolic shift",

author = "Desiree Abdurrachim and Luiken, {Joost J F P} and Klaas Nicolay and Glatz, {Jan F C} and Prompers, {Jeanine J.} and Miranda Nabben",

year = "2015",

month = may,

day = "1",

doi = "10.1093/cvr/cvv105",

language = "English",

volume = "106",

pages = "194--205",

journal = "Cardiovascular Research",

issn = "0008-6363",

publisher = "Oxford University Press",

number = "2",

}

TY - JOUR

T1 - Good and bad consequences of altered fatty acid metabolism in heart failure

T2 - Evidence from mouse models

AU - Abdurrachim, Desiree

AU - Luiken, Joost J F P

AU - Nicolay, Klaas

AU - Glatz, Jan F C

AU - Prompers, Jeanine J.

AU - Nabben, Miranda

PY - 2015/5/1

Y1 - 2015/5/1

N2 - The shift in substrate preference away from fatty acid oxidation (FAO) towards increased glucose utilization in heart failure has long been interpreted as an oxygen-sparing mechanism. Inhibition of FAO has therefore evolved as an accepted approach to treat heart failure. However, recent data indicate that increased reliance on glucose might be detrimental rather than beneficial for the failing heart. This review discusses new insights into metabolic adaptations in heart failure. A particular focus lies on data obtained from mouse models with modulations of cardiac FA metabolism at different levels of the FA metabolic pathway and how these differently affect cardiac function. Based on studies in which these mouse models were exposed to ischaemic and non-ischaemic heart failure, we discuss whether and when modulations in FA metabolism are protective against heart failure.

AB - The shift in substrate preference away from fatty acid oxidation (FAO) towards increased glucose utilization in heart failure has long been interpreted as an oxygen-sparing mechanism. Inhibition of FAO has therefore evolved as an accepted approach to treat heart failure. However, recent data indicate that increased reliance on glucose might be detrimental rather than beneficial for the failing heart. This review discusses new insights into metabolic adaptations in heart failure. A particular focus lies on data obtained from mouse models with modulations of cardiac FA metabolism at different levels of the FA metabolic pathway and how these differently affect cardiac function. Based on studies in which these mouse models were exposed to ischaemic and non-ischaemic heart failure, we discuss whether and when modulations in FA metabolism are protective against heart failure.

KW - Energy metabolism

KW - Genetically altered mice

KW - Heart failure

KW - Metabolic shift

UR - http://www.scopus.com/inward/record.url?scp=84929084424&partnerID=8YFLogxK

U2 - 10.1093/cvr/cvv105

DO - 10.1093/cvr/cvv105

M3 - Review article

C2 - 25765936

AN - SCOPUS:84929084424

SN - 0008-6363

VL - 106

SP - 194

EP - 205

JO - Cardiovascular Research

JF - Cardiovascular Research

IS - 2

ER -

Good and bad consequences of altered fatty acid metabolism in heart failure: Evidence from mouse models

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this