Global Spread of Human Chromoblastomycosis Is Driven by Recombinant Cladophialophora carrionii and Predominantly Clonal Fonsecaea Species

Shuwen Deng; Clement K M Tsui; A H G Gerrits van den Ende; Liyue Yang; Mohammad Javad Najafzadeh; Hamid Badali; Ruoyu Li; Ferry Hagen; Jacques F Meis; Jiufeng Sun; Somayeh Dolatabadi; Bernard Papierok; Weihua Pan; G S de Hoog; Wanqing Liao

doi:10.1371/journal.pntd.0004004

Global Spread of Human Chromoblastomycosis Is Driven by Recombinant Cladophialophora carrionii and Predominantly Clonal Fonsecaea Species

Shuwen Deng
, Clement K M Tsui
, A H G Gerrits van den Ende
, Liyue Yang
, Mohammad Javad Najafzadeh
, Hamid Badali
, Ruoyu Li
, Ferry Hagen
, Jacques F Meis
, Jiufeng Sun
, Somayeh Dolatabadi
, Bernard Papierok
, Weihua Pan
, G S de Hoog^*
, Wanqing Liao^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Global distribution patterns of Cladophialophora carrionii, agent of human chromoblastomycosis in arid climates of Africa, Asia, Australia, Central-and South-America, were compared with similar data of the vicarious Fonsecaea spp., agents of the disease in tropical rain forests. Population diversities among 73 C. carrionii strains and 60 strains of three Fonsecaea species were analyzed for rDNA ITS, partial β-tubulin, and amplified fragment-length polymorphism (AFLP) fingerprints. Populations differed significantly between continents. Lowest haplotype diversity was found in South American populations, while African strains were the most diverse. Gene flow was noted between the African population and all other continents. The general pattern of Fonsecaea agents of chromoblastomycosis differed significantly from that of C. carrionii and revealed deeper divergence among three differentiated species with smaller numbers of haplotypes, indicating a longer evolutionary history.

Original language	English
Article number	e0004004
Journal	PLoS neglected tropical diseases
Volume	9
Issue number	10
DOIs	https://doi.org/10.1371/journal.pntd.0004004
Publication status	Published - 2015
Externally published	Yes

Keywords

Amplified Fragment Length Polymorphism Analysis
Ascomycota/classification
Chromoblastomycosis/epidemiology
DNA, Fungal/chemistry
DNA, Ribosomal Spacer/chemistry
Desert Climate
Gene Flow
Genetic Variation
Genotype
Global Health
Haplotypes
Humans
Tropical Climate
Tubulin/genetics

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10.1371/journal.pntd.0004004

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Deng, S., Tsui, C. K. M., Gerrits van den Ende, A. H. G., Yang, L., Najafzadeh, M. J., Badali, H., Li, R., Hagen, F., Meis, J. F., Sun, J., Dolatabadi, S., Papierok, B., Pan, W., de Hoog, G. S., & Liao, W. (2015). Global Spread of Human Chromoblastomycosis Is Driven by Recombinant Cladophialophora carrionii and Predominantly Clonal Fonsecaea Species. PLoS neglected tropical diseases, 9(10), Article e0004004. https://doi.org/10.1371/journal.pntd.0004004

@article{faa3763fdf8d45569eeac08e23ec97b4,

title = "Global Spread of Human Chromoblastomycosis Is Driven by Recombinant Cladophialophora carrionii and Predominantly Clonal Fonsecaea Species",

abstract = "Global distribution patterns of Cladophialophora carrionii, agent of human chromoblastomycosis in arid climates of Africa, Asia, Australia, Central-and South-America, were compared with similar data of the vicarious Fonsecaea spp., agents of the disease in tropical rain forests. Population diversities among 73 C. carrionii strains and 60 strains of three Fonsecaea species were analyzed for rDNA ITS, partial β-tubulin, and amplified fragment-length polymorphism (AFLP) fingerprints. Populations differed significantly between continents. Lowest haplotype diversity was found in South American populations, while African strains were the most diverse. Gene flow was noted between the African population and all other continents. The general pattern of Fonsecaea agents of chromoblastomycosis differed significantly from that of C. carrionii and revealed deeper divergence among three differentiated species with smaller numbers of haplotypes, indicating a longer evolutionary history.",

keywords = "Amplified Fragment Length Polymorphism Analysis, Ascomycota/classification, Chromoblastomycosis/epidemiology, DNA, Fungal/chemistry, DNA, Ribosomal Spacer/chemistry, Desert Climate, Gene Flow, Genetic Variation, Genotype, Global Health, Haplotypes, Humans, Tropical Climate, Tubulin/genetics",

author = "Shuwen Deng and Tsui, \{Clement K M\} and \{Gerrits van den Ende\}, \{A H G\} and Liyue Yang and Najafzadeh, \{Mohammad Javad\} and Hamid Badali and Ruoyu Li and Ferry Hagen and Meis, \{Jacques F\} and Jiufeng Sun and Somayeh Dolatabadi and Bernard Papierok and Weihua Pan and \{de Hoog\}, \{G S\} and Wanqing Liao",

year = "2015",

doi = "10.1371/journal.pntd.0004004",

language = "English",

volume = "9",

journal = "PLoS neglected tropical diseases",

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}

Deng, S, Tsui, CKM, Gerrits van den Ende, AHG, Yang, L, Najafzadeh, MJ, Badali, H, Li, R, Hagen, F, Meis, JF, Sun, J, Dolatabadi, S, Papierok, B, Pan, W, de Hoog, GS & Liao, W 2015, 'Global Spread of Human Chromoblastomycosis Is Driven by Recombinant Cladophialophora carrionii and Predominantly Clonal Fonsecaea Species', PLoS neglected tropical diseases, vol. 9, no. 10, e0004004. https://doi.org/10.1371/journal.pntd.0004004

TY - JOUR

T1 - Global Spread of Human Chromoblastomycosis Is Driven by Recombinant Cladophialophora carrionii and Predominantly Clonal Fonsecaea Species

AU - Deng, Shuwen

AU - Tsui, Clement K M

AU - Gerrits van den Ende, A H G

AU - Yang, Liyue

AU - Najafzadeh, Mohammad Javad

AU - Badali, Hamid

AU - Li, Ruoyu

AU - Hagen, Ferry

AU - Meis, Jacques F

AU - Sun, Jiufeng

AU - Dolatabadi, Somayeh

AU - Papierok, Bernard

AU - Pan, Weihua

AU - de Hoog, G S

AU - Liao, Wanqing

PY - 2015

Y1 - 2015

N2 - Global distribution patterns of Cladophialophora carrionii, agent of human chromoblastomycosis in arid climates of Africa, Asia, Australia, Central-and South-America, were compared with similar data of the vicarious Fonsecaea spp., agents of the disease in tropical rain forests. Population diversities among 73 C. carrionii strains and 60 strains of three Fonsecaea species were analyzed for rDNA ITS, partial β-tubulin, and amplified fragment-length polymorphism (AFLP) fingerprints. Populations differed significantly between continents. Lowest haplotype diversity was found in South American populations, while African strains were the most diverse. Gene flow was noted between the African population and all other continents. The general pattern of Fonsecaea agents of chromoblastomycosis differed significantly from that of C. carrionii and revealed deeper divergence among three differentiated species with smaller numbers of haplotypes, indicating a longer evolutionary history.

AB - Global distribution patterns of Cladophialophora carrionii, agent of human chromoblastomycosis in arid climates of Africa, Asia, Australia, Central-and South-America, were compared with similar data of the vicarious Fonsecaea spp., agents of the disease in tropical rain forests. Population diversities among 73 C. carrionii strains and 60 strains of three Fonsecaea species were analyzed for rDNA ITS, partial β-tubulin, and amplified fragment-length polymorphism (AFLP) fingerprints. Populations differed significantly between continents. Lowest haplotype diversity was found in South American populations, while African strains were the most diverse. Gene flow was noted between the African population and all other continents. The general pattern of Fonsecaea agents of chromoblastomycosis differed significantly from that of C. carrionii and revealed deeper divergence among three differentiated species with smaller numbers of haplotypes, indicating a longer evolutionary history.

KW - Amplified Fragment Length Polymorphism Analysis

KW - Ascomycota/classification

KW - Chromoblastomycosis/epidemiology

KW - DNA, Fungal/chemistry

KW - DNA, Ribosomal Spacer/chemistry

KW - Desert Climate

KW - Gene Flow

KW - Genetic Variation

KW - Genotype

KW - Global Health

KW - Haplotypes

KW - Humans

KW - Tropical Climate

KW - Tubulin/genetics

U2 - 10.1371/journal.pntd.0004004

DO - 10.1371/journal.pntd.0004004

M3 - Article

C2 - 26496430

SN - 1935-2727

VL - 9

JO - PLoS neglected tropical diseases

JF - PLoS neglected tropical diseases

IS - 10

M1 - e0004004

ER -

Global Spread of Human Chromoblastomycosis Is Driven by Recombinant Cladophialophora carrionii and Predominantly Clonal Fonsecaea Species

Abstract

Keywords

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