Global molecular diversity of RSV - the "INFORM RSV" study

Annefleur C Langedijk; Robert Jan Lebbink; Christiana Naaktgeboren; Anouk Evers; Marco C Viveen; Anne Greenough; Terho Heikkinen; Renato T Stein; Peter Richmond; Federico Martinón-Torres; Marta Nunes; Mitsuaki Hosoya; Christian Keller; Monika Bauck; Robert Cohen; Jesse Papenburg; Jeffrey Pernica; Marije P Hennus; Hong Jin; David E Tabor; Andrev Tovchigrechko; Alexey Ruzin; Michael E Abram; Deidre Wilkins; Joanne G Wildenbeest; Leyla Kragten-Tabatabaie; Frank E J Coenjaerts; Mark T Esser; Louis J Bont

doi:10.1186/s12879-020-05175-4

Global molecular diversity of RSV - the "INFORM RSV" study

Annefleur C Langedijk, Robert Jan Lebbink, Christiana Naaktgeboren, Anouk Evers, Marco C Viveen, Anne Greenough, Terho Heikkinen, Renato T Stein, Peter Richmond, Federico Martinón-Torres, Marta Nunes, Mitsuaki Hosoya, Christian Keller, Monika Bauck, Robert Cohen, Jesse Papenburg, Jeffrey Pernica, Marije P Hennus, Hong Jin, David E TaborAndrev Tovchigrechko, Alexey Ruzin, Michael E Abram, Deidre Wilkins, Joanne G Wildenbeest, Leyla Kragten-Tabatabaie, Frank E J Coenjaerts, Mark T Esser, Louis J Bont

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Abstract

BACKGROUND: Respiratory syncytial virus (RSV) is a global cause of severe respiratory morbidity and mortality in infants. While preventive and therapeutic interventions are being developed, including antivirals, vaccines and monoclonal antibodies, little is known about the global molecular epidemiology of RSV. INFORM is a prospective, multicenter, global clinical study performed by ReSViNET to investigate the worldwide molecular diversity of RSV isolates collected from children less than 5 years of age.

METHODS: The INFORM study is performed in 17 countries spanning all inhabited continents and will provide insight into the molecular epidemiology of circulating RSV strains worldwide. Sequencing of > 4000 RSV-positive respiratory samples is planned to detect temporal and geographical molecular patterns on a molecular level over five consecutive years. Additionally, RSV will be cultured from a subset of samples to study the functional implications of specific mutations in the viral genome including viral fitness and susceptibility to different monoclonal antibodies.

DISCUSSION: The sequencing and functional results will be used to investigate susceptibility and resistance to novel RSV preventive or therapeutic interventions. Finally, a repository of globally collected RSV strains and a database of RSV sequences will be created.

Original language	English
Article number	450
Journal	BMC Infectious Diseases
Volume	20
Issue number	1
DOIs	https://doi.org/10.1186/s12879-020-05175-4
Publication status	Published - 26 Jun 2020

Keywords

Molecular epidemiology
Monoclonal antibodies
Next generation sequencing
Respiratory syncytial virus
Temporal and geographical diversity
Vaccines

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Langedijk, A. C., Lebbink, R. J., Naaktgeboren, C., Evers, A., Viveen, M. C., Greenough, A., Heikkinen, T., Stein, R. T., Richmond, P., Martinón-Torres, F., Nunes, M., Hosoya, M., Keller, C., Bauck, M., Cohen, R., Papenburg, J., Pernica, J., Hennus, M. P., Jin, H., ... Bont, L. J. (2020). Global molecular diversity of RSV - the "INFORM RSV" study. BMC Infectious Diseases, 20(1), Article 450. https://doi.org/10.1186/s12879-020-05175-4

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abstract = "BACKGROUND: Respiratory syncytial virus (RSV) is a global cause of severe respiratory morbidity and mortality in infants. While preventive and therapeutic interventions are being developed, including antivirals, vaccines and monoclonal antibodies, little is known about the global molecular epidemiology of RSV. INFORM is a prospective, multicenter, global clinical study performed by ReSViNET to investigate the worldwide molecular diversity of RSV isolates collected from children less than 5 years of age.METHODS: The INFORM study is performed in 17 countries spanning all inhabited continents and will provide insight into the molecular epidemiology of circulating RSV strains worldwide. Sequencing of > 4000 RSV-positive respiratory samples is planned to detect temporal and geographical molecular patterns on a molecular level over five consecutive years. Additionally, RSV will be cultured from a subset of samples to study the functional implications of specific mutations in the viral genome including viral fitness and susceptibility to different monoclonal antibodies.DISCUSSION: The sequencing and functional results will be used to investigate susceptibility and resistance to novel RSV preventive or therapeutic interventions. Finally, a repository of globally collected RSV strains and a database of RSV sequences will be created.",

keywords = "Molecular epidemiology, Monoclonal antibodies, Next generation sequencing, Respiratory syncytial virus, Temporal and geographical diversity, Vaccines",

author = "Langedijk, {Annefleur C} and Lebbink, {Robert Jan} and Christiana Naaktgeboren and Anouk Evers and Viveen, {Marco C} and Anne Greenough and Terho Heikkinen and Stein, {Renato T} and Peter Richmond and Federico Martin{\'o}n-Torres and Marta Nunes and Mitsuaki Hosoya and Christian Keller and Monika Bauck and Robert Cohen and Jesse Papenburg and Jeffrey Pernica and Hennus, {Marije P} and Hong Jin and Tabor, {David E} and Andrev Tovchigrechko and Alexey Ruzin and Abram, {Michael E} and Deidre Wilkins and Wildenbeest, {Joanne G} and Leyla Kragten-Tabatabaie and Coenjaerts, {Frank E J} and Esser, {Mark T} and Bont, {Louis J}",

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Langedijk, AC, Lebbink, RJ, Naaktgeboren, C, Evers, A, Viveen, MC, Greenough, A, Heikkinen, T, Stein, RT, Richmond, P, Martinón-Torres, F, Nunes, M, Hosoya, M, Keller, C, Bauck, M, Cohen, R, Papenburg, J, Pernica, J, Hennus, MP, Jin, H, Tabor, DE, Tovchigrechko, A, Ruzin, A, Abram, ME, Wilkins, D, Wildenbeest, JG, Kragten-Tabatabaie, L, Coenjaerts, FEJ, Esser, MT & Bont, LJ 2020, 'Global molecular diversity of RSV - the "INFORM RSV" study', BMC Infectious Diseases, vol. 20, no. 1, 450. https://doi.org/10.1186/s12879-020-05175-4

TY - JOUR

T1 - Global molecular diversity of RSV - the "INFORM RSV" study

AU - Langedijk, Annefleur C

AU - Lebbink, Robert Jan

AU - Naaktgeboren, Christiana

AU - Evers, Anouk

AU - Viveen, Marco C

AU - Greenough, Anne

AU - Heikkinen, Terho

AU - Stein, Renato T

AU - Richmond, Peter

AU - Martinón-Torres, Federico

AU - Nunes, Marta

AU - Hosoya, Mitsuaki

AU - Keller, Christian

AU - Bauck, Monika

AU - Cohen, Robert

AU - Papenburg, Jesse

AU - Pernica, Jeffrey

AU - Hennus, Marije P

AU - Jin, Hong

AU - Tabor, David E

AU - Tovchigrechko, Andrev

AU - Ruzin, Alexey

AU - Abram, Michael E

AU - Wilkins, Deidre

AU - Wildenbeest, Joanne G

AU - Kragten-Tabatabaie, Leyla

AU - Coenjaerts, Frank E J

AU - Esser, Mark T

AU - Bont, Louis J

PY - 2020/6/26

Y1 - 2020/6/26

N2 - BACKGROUND: Respiratory syncytial virus (RSV) is a global cause of severe respiratory morbidity and mortality in infants. While preventive and therapeutic interventions are being developed, including antivirals, vaccines and monoclonal antibodies, little is known about the global molecular epidemiology of RSV. INFORM is a prospective, multicenter, global clinical study performed by ReSViNET to investigate the worldwide molecular diversity of RSV isolates collected from children less than 5 years of age.METHODS: The INFORM study is performed in 17 countries spanning all inhabited continents and will provide insight into the molecular epidemiology of circulating RSV strains worldwide. Sequencing of > 4000 RSV-positive respiratory samples is planned to detect temporal and geographical molecular patterns on a molecular level over five consecutive years. Additionally, RSV will be cultured from a subset of samples to study the functional implications of specific mutations in the viral genome including viral fitness and susceptibility to different monoclonal antibodies.DISCUSSION: The sequencing and functional results will be used to investigate susceptibility and resistance to novel RSV preventive or therapeutic interventions. Finally, a repository of globally collected RSV strains and a database of RSV sequences will be created.

AB - BACKGROUND: Respiratory syncytial virus (RSV) is a global cause of severe respiratory morbidity and mortality in infants. While preventive and therapeutic interventions are being developed, including antivirals, vaccines and monoclonal antibodies, little is known about the global molecular epidemiology of RSV. INFORM is a prospective, multicenter, global clinical study performed by ReSViNET to investigate the worldwide molecular diversity of RSV isolates collected from children less than 5 years of age.METHODS: The INFORM study is performed in 17 countries spanning all inhabited continents and will provide insight into the molecular epidemiology of circulating RSV strains worldwide. Sequencing of > 4000 RSV-positive respiratory samples is planned to detect temporal and geographical molecular patterns on a molecular level over five consecutive years. Additionally, RSV will be cultured from a subset of samples to study the functional implications of specific mutations in the viral genome including viral fitness and susceptibility to different monoclonal antibodies.DISCUSSION: The sequencing and functional results will be used to investigate susceptibility and resistance to novel RSV preventive or therapeutic interventions. Finally, a repository of globally collected RSV strains and a database of RSV sequences will be created.

KW - Molecular epidemiology

KW - Monoclonal antibodies

KW - Next generation sequencing

KW - Respiratory syncytial virus

KW - Temporal and geographical diversity

KW - Vaccines

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U2 - 10.1186/s12879-020-05175-4

DO - 10.1186/s12879-020-05175-4

M3 - Article

C2 - 32591017

SN - 1471-2334

VL - 20

JO - BMC Infectious Diseases

JF - BMC Infectious Diseases

IS - 1

M1 - 450

ER -

Global molecular diversity of RSV - the "INFORM RSV" study

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