Global Cardio Oncology Registry (G-COR): Registry Design, Primary Objectives, and Future Perspectives of a Multicenter Global Initiative

Arco J Teske; Rohit Moudgil; Teresa López-Fernández; Ana Barac; Sherry Ann Brown; Anita Deswal; Tomas G Neilan; Sarju Ganatra; Husam Abdel Qadir; Venu Menon; Aaron L Sverdlov; Richard K Cheng; Silvia Makhoul; Arjun K Ghosh; Sebastian Szmit; Vlad Zaha; Daniel Addison; Lili Zhang; Joerg Herrmann; Jun H Chong; Vivek Agarwala; Zaza Iakobishvili; Patricia Guerrero; Eric H Yang; Monika Leja; Nausheen Akhter; Avirup Guha; Tochukwu M Okwuosa; Carolina Carvalho Silva; Patrick Collier; Jeanne DeCara; Brenton Bauer; Carrie E Lenneman; Diego Sadler

doi:10.1161/CIRCOUTCOMES.123.009905

Global Cardio Oncology Registry (G-COR): Registry Design, Primary Objectives, and Future Perspectives of a Multicenter Global Initiative

Arco J Teske, Rohit Moudgil, Teresa López-Fernández, Ana Barac, Sherry Ann Brown, Anita Deswal, Tomas G Neilan, Sarju Ganatra, Husam Abdel Qadir, Venu Menon, Aaron L Sverdlov, Richard K Cheng, Silvia Makhoul, Arjun K Ghosh, Sebastian Szmit, Vlad Zaha, Daniel Addison, Lili Zhang, Joerg Herrmann, Jun H ChongVivek Agarwala, Zaza Iakobishvili, Patricia Guerrero, Eric H Yang, Monika Leja, Nausheen Akhter, Avirup Guha, Tochukwu M Okwuosa, Carolina Carvalho Silva, Patrick Collier, Jeanne DeCara, Brenton Bauer, Carrie E Lenneman, Diego Sadler^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Global collaboration in cardio-oncology is needed to understand the prevalence of cancer therapy-related cardiovascular toxicity in different risk groups, practice settings, and geographic locations. There are limited data on the socioeconomic and racial/ethnic disparities that may impact access to care and outcomes. To address these gaps, we established the Global Cardio-Oncology Registry, a multinational, multicenter prospective registry.

METHODS: We assembled cardiologists and oncologists from academic and community settings to collaborate in the first Global Cardio-Oncology Registry. Subsequently, a survey for site resources, demographics, and intention to participate was conducted. We designed an online data platform to facilitate this global initiative.

RESULTS: A total of 119 sites responded to an online questionnaire on their practices and main goals of the registry: 49 US sites from 23 states and 70 international sites from 5 continents indicated a willingness to participate in the Global Cardio-Oncology Registry. Sites were more commonly led by cardiologists (85/119; 72%) and were more often university/teaching (81/119; 68%) than community based (38/119; 32%). The average number of cardio-oncology patients treated per month was 80 per site. The top 3 Global Cardio-Oncology Registry priorities in cardio-oncology care were breast cancer, hematologic malignancies, and patients treated with immune checkpoint inhibitors. Executive and scientific committees and specific committees were established. A pilot phase for breast cancer using Research Electronic Data Capture Cloud platform recently started patient enrollment.

CONCLUSIONS: We present the structure for a global collaboration. Information derived from the Global Cardio-Oncology Registry will help understand the risk factors impacting cancer therapy-related cardiovascular toxicity in different geographic locations and therefore contribute to reduce access gaps in cardio-oncology care. Risk calculators will be prospectively derived and validated.

Original language	English
Article number	e009905
Pages (from-to)	718-728
Number of pages	11
Journal	Circulation. Cardiovascular Quality and Outcomes
Volume	16
Issue number	10
DOIs	https://doi.org/10.1161/CIRCOUTCOMES.123.009905
Publication status	Published - Oct 2023

Keywords

Breast Neoplasms
Cardiologists
Cardiology
Female
Humans
Medical Oncology
Multicenter Studies as Topic
Neoplasms/diagnosis
Registries

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10.1161/CIRCOUTCOMES.123.009905

Cite this

Teske, A. J., Moudgil, R., López-Fernández, T., Barac, A., Brown, S. A., Deswal, A., Neilan, T. G., Ganatra, S., Abdel Qadir, H., Menon, V., Sverdlov, A. L., Cheng, R. K., Makhoul, S., Ghosh, A. K., Szmit, S., Zaha, V., Addison, D., Zhang, L., Herrmann, J., ... Sadler, D. (2023). Global Cardio Oncology Registry (G-COR): Registry Design, Primary Objectives, and Future Perspectives of a Multicenter Global Initiative. Circulation. Cardiovascular Quality and Outcomes, 16(10), 718-728. Article e009905. https://doi.org/10.1161/CIRCOUTCOMES.123.009905

@article{ef7e4ce55fc846408debd1990d838440,

title = "Global Cardio Oncology Registry (G-COR): Registry Design, Primary Objectives, and Future Perspectives of a Multicenter Global Initiative",

abstract = "BACKGROUND: Global collaboration in cardio-oncology is needed to understand the prevalence of cancer therapy-related cardiovascular toxicity in different risk groups, practice settings, and geographic locations. There are limited data on the socioeconomic and racial/ethnic disparities that may impact access to care and outcomes. To address these gaps, we established the Global Cardio-Oncology Registry, a multinational, multicenter prospective registry.METHODS: We assembled cardiologists and oncologists from academic and community settings to collaborate in the first Global Cardio-Oncology Registry. Subsequently, a survey for site resources, demographics, and intention to participate was conducted. We designed an online data platform to facilitate this global initiative.RESULTS: A total of 119 sites responded to an online questionnaire on their practices and main goals of the registry: 49 US sites from 23 states and 70 international sites from 5 continents indicated a willingness to participate in the Global Cardio-Oncology Registry. Sites were more commonly led by cardiologists (85/119; 72%) and were more often university/teaching (81/119; 68%) than community based (38/119; 32%). The average number of cardio-oncology patients treated per month was 80 per site. The top 3 Global Cardio-Oncology Registry priorities in cardio-oncology care were breast cancer, hematologic malignancies, and patients treated with immune checkpoint inhibitors. Executive and scientific committees and specific committees were established. A pilot phase for breast cancer using Research Electronic Data Capture Cloud platform recently started patient enrollment.CONCLUSIONS: We present the structure for a global collaboration. Information derived from the Global Cardio-Oncology Registry will help understand the risk factors impacting cancer therapy-related cardiovascular toxicity in different geographic locations and therefore contribute to reduce access gaps in cardio-oncology care. Risk calculators will be prospectively derived and validated.",

keywords = "Breast Neoplasms, Cardiologists, Cardiology, Female, Humans, Medical Oncology, Multicenter Studies as Topic, Neoplasms/diagnosis, Registries",

author = "Teske, {Arco J} and Rohit Moudgil and Teresa L{\'o}pez-Fern{\'a}ndez and Ana Barac and Brown, {Sherry Ann} and Anita Deswal and Neilan, {Tomas G} and Sarju Ganatra and {Abdel Qadir}, Husam and Venu Menon and Sverdlov, {Aaron L} and Cheng, {Richard K} and Silvia Makhoul and Ghosh, {Arjun K} and Sebastian Szmit and Vlad Zaha and Daniel Addison and Lili Zhang and Joerg Herrmann and Chong, {Jun H} and Vivek Agarwala and Zaza Iakobishvili and Patricia Guerrero and Yang, {Eric H} and Monika Leja and Nausheen Akhter and Avirup Guha and Okwuosa, {Tochukwu M} and Silva, {Carolina Carvalho} and Patrick Collier and Jeanne DeCara and Brenton Bauer and Lenneman, {Carrie E} and Diego Sadler",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors. Circulation: Cardiovascular Interventions is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc.",

year = "2023",

month = oct,

doi = "10.1161/CIRCOUTCOMES.123.009905",

language = "English",

volume = "16",

pages = "718--728",

journal = "Circulation. Cardiovascular Quality and Outcomes",

issn = "1941-7713",

publisher = "Lippincott Williams & Wilkins",

number = "10",

}

Teske, AJ, Moudgil, R, López-Fernández, T, Barac, A, Brown, SA, Deswal, A, Neilan, TG, Ganatra, S, Abdel Qadir, H, Menon, V, Sverdlov, AL, Cheng, RK, Makhoul, S, Ghosh, AK, Szmit, S, Zaha, V, Addison, D, Zhang, L, Herrmann, J, Chong, JH, Agarwala, V, Iakobishvili, Z, Guerrero, P, Yang, EH, Leja, M, Akhter, N, Guha, A, Okwuosa, TM, Silva, CC, Collier, P, DeCara, J, Bauer, B, Lenneman, CE & Sadler, D 2023, 'Global Cardio Oncology Registry (G-COR): Registry Design, Primary Objectives, and Future Perspectives of a Multicenter Global Initiative', Circulation. Cardiovascular Quality and Outcomes, vol. 16, no. 10, e009905, pp. 718-728. https://doi.org/10.1161/CIRCOUTCOMES.123.009905

Global Cardio Oncology Registry (G-COR): Registry Design, Primary Objectives, and Future Perspectives of a Multicenter Global Initiative. / Teske, Arco J; Moudgil, Rohit; López-Fernández, Teresa et al.
In: Circulation. Cardiovascular Quality and Outcomes, Vol. 16, No. 10, e009905, 10.2023, p. 718-728.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Global Cardio Oncology Registry (G-COR)

T2 - Registry Design, Primary Objectives, and Future Perspectives of a Multicenter Global Initiative

AU - Teske, Arco J

AU - Moudgil, Rohit

AU - López-Fernández, Teresa

AU - Barac, Ana

AU - Brown, Sherry Ann

AU - Deswal, Anita

AU - Neilan, Tomas G

AU - Ganatra, Sarju

AU - Abdel Qadir, Husam

AU - Menon, Venu

AU - Sverdlov, Aaron L

AU - Cheng, Richard K

AU - Makhoul, Silvia

AU - Ghosh, Arjun K

AU - Szmit, Sebastian

AU - Zaha, Vlad

AU - Addison, Daniel

AU - Zhang, Lili

AU - Herrmann, Joerg

AU - Chong, Jun H

AU - Agarwala, Vivek

AU - Iakobishvili, Zaza

AU - Guerrero, Patricia

AU - Yang, Eric H

AU - Leja, Monika

AU - Akhter, Nausheen

AU - Guha, Avirup

AU - Okwuosa, Tochukwu M

AU - Silva, Carolina Carvalho

AU - Collier, Patrick

AU - DeCara, Jeanne

AU - Bauer, Brenton

AU - Lenneman, Carrie E

AU - Sadler, Diego

PY - 2023/10

Y1 - 2023/10

N2 - BACKGROUND: Global collaboration in cardio-oncology is needed to understand the prevalence of cancer therapy-related cardiovascular toxicity in different risk groups, practice settings, and geographic locations. There are limited data on the socioeconomic and racial/ethnic disparities that may impact access to care and outcomes. To address these gaps, we established the Global Cardio-Oncology Registry, a multinational, multicenter prospective registry.METHODS: We assembled cardiologists and oncologists from academic and community settings to collaborate in the first Global Cardio-Oncology Registry. Subsequently, a survey for site resources, demographics, and intention to participate was conducted. We designed an online data platform to facilitate this global initiative.RESULTS: A total of 119 sites responded to an online questionnaire on their practices and main goals of the registry: 49 US sites from 23 states and 70 international sites from 5 continents indicated a willingness to participate in the Global Cardio-Oncology Registry. Sites were more commonly led by cardiologists (85/119; 72%) and were more often university/teaching (81/119; 68%) than community based (38/119; 32%). The average number of cardio-oncology patients treated per month was 80 per site. The top 3 Global Cardio-Oncology Registry priorities in cardio-oncology care were breast cancer, hematologic malignancies, and patients treated with immune checkpoint inhibitors. Executive and scientific committees and specific committees were established. A pilot phase for breast cancer using Research Electronic Data Capture Cloud platform recently started patient enrollment.CONCLUSIONS: We present the structure for a global collaboration. Information derived from the Global Cardio-Oncology Registry will help understand the risk factors impacting cancer therapy-related cardiovascular toxicity in different geographic locations and therefore contribute to reduce access gaps in cardio-oncology care. Risk calculators will be prospectively derived and validated.

AB - BACKGROUND: Global collaboration in cardio-oncology is needed to understand the prevalence of cancer therapy-related cardiovascular toxicity in different risk groups, practice settings, and geographic locations. There are limited data on the socioeconomic and racial/ethnic disparities that may impact access to care and outcomes. To address these gaps, we established the Global Cardio-Oncology Registry, a multinational, multicenter prospective registry.METHODS: We assembled cardiologists and oncologists from academic and community settings to collaborate in the first Global Cardio-Oncology Registry. Subsequently, a survey for site resources, demographics, and intention to participate was conducted. We designed an online data platform to facilitate this global initiative.RESULTS: A total of 119 sites responded to an online questionnaire on their practices and main goals of the registry: 49 US sites from 23 states and 70 international sites from 5 continents indicated a willingness to participate in the Global Cardio-Oncology Registry. Sites were more commonly led by cardiologists (85/119; 72%) and were more often university/teaching (81/119; 68%) than community based (38/119; 32%). The average number of cardio-oncology patients treated per month was 80 per site. The top 3 Global Cardio-Oncology Registry priorities in cardio-oncology care were breast cancer, hematologic malignancies, and patients treated with immune checkpoint inhibitors. Executive and scientific committees and specific committees were established. A pilot phase for breast cancer using Research Electronic Data Capture Cloud platform recently started patient enrollment.CONCLUSIONS: We present the structure for a global collaboration. Information derived from the Global Cardio-Oncology Registry will help understand the risk factors impacting cancer therapy-related cardiovascular toxicity in different geographic locations and therefore contribute to reduce access gaps in cardio-oncology care. Risk calculators will be prospectively derived and validated.

KW - Breast Neoplasms

KW - Cardiologists

KW - Cardiology

KW - Female

KW - Humans

KW - Medical Oncology

KW - Multicenter Studies as Topic

KW - Neoplasms/diagnosis

KW - Registries

UR - http://www.scopus.com/inward/record.url?scp=85173912817&partnerID=8YFLogxK

U2 - 10.1161/CIRCOUTCOMES.123.009905

DO - 10.1161/CIRCOUTCOMES.123.009905

M3 - Article

C2 - 37702048

SN - 1941-7713

VL - 16

SP - 718

EP - 728

JO - Circulation. Cardiovascular Quality and Outcomes

JF - Circulation. Cardiovascular Quality and Outcomes

IS - 10

M1 - e009905

ER -

Global Cardio Oncology Registry (G-COR): Registry Design, Primary Objectives, and Future Perspectives of a Multicenter Global Initiative

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Keywords

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