Glioma EVs Contribute to Immune Privilege in the Brain

Erik R. Abels; Marike L.D. Broekman; Xandra O. Breakefield; Sybren L.N. Maas

doi:10.1016/j.trecan.2019.05.006

Glioma EVs Contribute to Immune Privilege in the Brain

Erik R. Abels, Marike L.D. Broekman, Xandra O. Breakefield, Sybren L.N. Maas^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Glioblastoma cells release extracellular vesicles (EVs), sometimes referred to as microvesicles and exosomes, to transfer immune modulating molecules to immune cells, resulting in an immune privileged microenvironment. Here we discuss the potential EV-mediated mechanisms underlying glioma immune modulation, as well as the technical difficulties in studying these interactions.

Original language	English
Pages (from-to)	393-396
Number of pages	4
Journal	Trends in Cancer
Volume	5
Issue number	7
DOIs	https://doi.org/10.1016/j.trecan.2019.05.006
Publication status	Published - 1 Jul 2019

Keywords

exosomes
extracellular vesicles
glioblastoma
glioma
immunity

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10.1016/j.trecan.2019.05.006

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title = "Glioma EVs Contribute to Immune Privilege in the Brain",

abstract = "Glioblastoma cells release extracellular vesicles (EVs), sometimes referred to as microvesicles and exosomes, to transfer immune modulating molecules to immune cells, resulting in an immune privileged microenvironment. Here we discuss the potential EV-mediated mechanisms underlying glioma immune modulation, as well as the technical difficulties in studying these interactions.",

keywords = "exosomes, extracellular vesicles, glioblastoma, glioma, immunity",

author = "Abels, {Erik R.} and Broekman, {Marike L.D.} and Breakefield, {Xandra O.} and Maas, {Sybren L.N.}",

year = "2019",

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AU - Abels, Erik R.

AU - Broekman, Marike L.D.

AU - Breakefield, Xandra O.

AU - Maas, Sybren L.N.

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Glioblastoma cells release extracellular vesicles (EVs), sometimes referred to as microvesicles and exosomes, to transfer immune modulating molecules to immune cells, resulting in an immune privileged microenvironment. Here we discuss the potential EV-mediated mechanisms underlying glioma immune modulation, as well as the technical difficulties in studying these interactions.

AB - Glioblastoma cells release extracellular vesicles (EVs), sometimes referred to as microvesicles and exosomes, to transfer immune modulating molecules to immune cells, resulting in an immune privileged microenvironment. Here we discuss the potential EV-mediated mechanisms underlying glioma immune modulation, as well as the technical difficulties in studying these interactions.

KW - exosomes

KW - extracellular vesicles

KW - glioblastoma

KW - glioma

KW - immunity

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U2 - 10.1016/j.trecan.2019.05.006

DO - 10.1016/j.trecan.2019.05.006

M3 - Review article

C2 - 31311653

AN - SCOPUS:85066444240

SN - 2405-8033

VL - 5

SP - 393

EP - 396

JO - Trends in Cancer

JF - Trends in Cancer

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ER -

Glioma EVs Contribute to Immune Privilege in the Brain

Abstract

Keywords

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