GFAP-isoforms in the nervous system: Understanding the need for diversity

Alexandra J E M de Reus; Onur Basak; Werner Dykstra; Jessy V van Asperen; Emma J van Bodegraven; Elly M Hol

doi:10.1016/j.ceb.2024.102340

GFAP-isoforms in the nervous system: Understanding the need for diversity

Alexandra J E M de Reus, Onur Basak, Werner Dykstra, Jessy V van Asperen, Emma J van Bodegraven, Elly M Hol^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

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Abstract

Glial fibrillary acidic protein (GFAP) is an intermediate filament (IF) protein expressed in specific types of glial cells in the nervous system. The expression of GFAP is highly regulated during brain development and in neurological diseases. The presence of distinct GFAP-isoforms in various cell types, developmental stages, and diseases indicates that GFAP (post-)transcriptional regulation has a role in glial cell physiology and pathology. GFAP-isoforms differ in sub-cellular localisation, IF-network assembly properties, and IF-dynamics which results in distinct molecular interactions and mechanical properties of the IF-network. Therefore, GFAP (post-)transcriptional regulation is likely a mechanism by which radial glia, astrocytes, and glioma cells can modulate cellular function.

Original language	English
Article number	102340
Journal	Current Opinion in Cell Biology
Volume	87
Early online date	23 Feb 2024
DOIs	https://doi.org/10.1016/j.ceb.2024.102340
Publication status	Published - Apr 2024

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1-s2.0-S095506742400019X-mainFinal published version, 1.03 MBLicence: CC BY

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@article{86d907284c2c495f864c3e07dd5dea83,

title = "GFAP-isoforms in the nervous system: Understanding the need for diversity",

abstract = "Glial fibrillary acidic protein (GFAP) is an intermediate filament (IF) protein expressed in specific types of glial cells in the nervous system. The expression of GFAP is highly regulated during brain development and in neurological diseases. The presence of distinct GFAP-isoforms in various cell types, developmental stages, and diseases indicates that GFAP (post-)transcriptional regulation has a role in glial cell physiology and pathology. GFAP-isoforms differ in sub-cellular localisation, IF-network assembly properties, and IF-dynamics which results in distinct molecular interactions and mechanical properties of the IF-network. Therefore, GFAP (post-)transcriptional regulation is likely a mechanism by which radial glia, astrocytes, and glioma cells can modulate cellular function.",

author = "{de Reus}, {Alexandra J E M} and Onur Basak and Werner Dykstra and {van Asperen}, {Jessy V} and {van Bodegraven}, {Emma J} and Hol, {Elly M}",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s)",

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doi = "10.1016/j.ceb.2024.102340",

language = "English",

volume = "87",

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T1 - GFAP-isoforms in the nervous system

T2 - Understanding the need for diversity

AU - de Reus, Alexandra J E M

AU - Basak, Onur

AU - Dykstra, Werner

AU - van Asperen, Jessy V

AU - van Bodegraven, Emma J

AU - Hol, Elly M

PY - 2024/4

Y1 - 2024/4

N2 - Glial fibrillary acidic protein (GFAP) is an intermediate filament (IF) protein expressed in specific types of glial cells in the nervous system. The expression of GFAP is highly regulated during brain development and in neurological diseases. The presence of distinct GFAP-isoforms in various cell types, developmental stages, and diseases indicates that GFAP (post-)transcriptional regulation has a role in glial cell physiology and pathology. GFAP-isoforms differ in sub-cellular localisation, IF-network assembly properties, and IF-dynamics which results in distinct molecular interactions and mechanical properties of the IF-network. Therefore, GFAP (post-)transcriptional regulation is likely a mechanism by which radial glia, astrocytes, and glioma cells can modulate cellular function.

AB - Glial fibrillary acidic protein (GFAP) is an intermediate filament (IF) protein expressed in specific types of glial cells in the nervous system. The expression of GFAP is highly regulated during brain development and in neurological diseases. The presence of distinct GFAP-isoforms in various cell types, developmental stages, and diseases indicates that GFAP (post-)transcriptional regulation has a role in glial cell physiology and pathology. GFAP-isoforms differ in sub-cellular localisation, IF-network assembly properties, and IF-dynamics which results in distinct molecular interactions and mechanical properties of the IF-network. Therefore, GFAP (post-)transcriptional regulation is likely a mechanism by which radial glia, astrocytes, and glioma cells can modulate cellular function.

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U2 - 10.1016/j.ceb.2024.102340

DO - 10.1016/j.ceb.2024.102340

M3 - Review article

C2 - 38401182

SN - 0955-0674

VL - 87

JO - Current Opinion in Cell Biology

JF - Current Opinion in Cell Biology

M1 - 102340

ER -

GFAP-isoforms in the nervous system: Understanding the need for diversity

Abstract

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