Getting the genome in shape: the formation of loops, domains and compartments

Britta A M Bouwman; Wouter de Laat

doi:10.1186/s13059-015-0730-1

Getting the genome in shape: the formation of loops, domains and compartments

Britta A M Bouwman
, Wouter de Laat

Cancer

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

The hierarchical levels of genome architecture exert transcriptional control by tuning the accessibility and proximity of genes and regulatory elements. Here, we review current insights into the trans-acting factors that enable the genome to flexibly adopt different functionally relevant conformations.

Original language	English
Journal	Genome Biology
Volume	16
Issue number	154
DOIs	https://doi.org/10.1186/s13059-015-0730-1
Publication status	Published - 2015

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title = "Getting the genome in shape: the formation of loops, domains and compartments",

abstract = "The hierarchical levels of genome architecture exert transcriptional control by tuning the accessibility and proximity of genes and regulatory elements. Here, we review current insights into the trans-acting factors that enable the genome to flexibly adopt different functionally relevant conformations.",

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JO - Genome Biology

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Getting the genome in shape: the formation of loops, domains and compartments

Abstract

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