Getting the genome in shape: the formation of loops, domains and compartments

Britta A M Bouwman; Wouter de Laat

doi:10.1186/s13059-015-0730-1

Getting the genome in shape: the formation of loops, domains and compartments

Britta A M Bouwman, Wouter de Laat

Cancer

Research output: Contribution to journal › Article › Academic › peer-review

1 Downloads (Pure)

Abstract

The hierarchical levels of genome architecture exert transcriptional control by tuning the accessibility and proximity of genes and regulatory elements. Here, we review current insights into the trans-acting factors that enable the genome to flexibly adopt different functionally relevant conformations.

Original language	English
Journal	Genome Biology
Volume	16
Issue number	154
DOIs	https://doi.org/10.1186/s13059-015-0730-1
Publication status	Published - 2015

Access to Document

10.1186/s13059-015-0730-1

shapeFinal published version, 1.2 MB

Cite this

@article{e7d23b1b99e74625a0cd51e1bdf24b7f,

title = "Getting the genome in shape: the formation of loops, domains and compartments",

abstract = "The hierarchical levels of genome architecture exert transcriptional control by tuning the accessibility and proximity of genes and regulatory elements. Here, we review current insights into the trans-acting factors that enable the genome to flexibly adopt different functionally relevant conformations.",

author = "Bouwman, {Britta A M} and {de Laat}, Wouter",

year = "2015",

doi = "10.1186/s13059-015-0730-1",

language = "English",

volume = "16",

journal = "Genome Biology",

issn = "1465-6906",

publisher = "BioMed Central",

number = "154",

}

TY - JOUR

T1 - Getting the genome in shape

T2 - the formation of loops, domains and compartments

AU - Bouwman, Britta A M

AU - de Laat, Wouter

PY - 2015

Y1 - 2015

N2 - The hierarchical levels of genome architecture exert transcriptional control by tuning the accessibility and proximity of genes and regulatory elements. Here, we review current insights into the trans-acting factors that enable the genome to flexibly adopt different functionally relevant conformations.

AB - The hierarchical levels of genome architecture exert transcriptional control by tuning the accessibility and proximity of genes and regulatory elements. Here, we review current insights into the trans-acting factors that enable the genome to flexibly adopt different functionally relevant conformations.

U2 - 10.1186/s13059-015-0730-1

DO - 10.1186/s13059-015-0730-1

M3 - Article

C2 - 26257189

SN - 1465-6906

VL - 16

JO - Genome Biology

JF - Genome Biology

IS - 154

ER -

Getting the genome in shape: the formation of loops, domains and compartments

Abstract

Access to Document

Fingerprint

Cite this