TY - JOUR
T1 - GetReal in network meta-analysis
T2 - a review of the methodology
AU - Efthimiou, Orestis
AU - Debray, Thomas P A
AU - van Valkenhoef, Gert
AU - Trelle, Sven
AU - Panayidou, Klea
AU - Moons, Karel G M
AU - Reitsma, Johannes B.
AU - Shang, Aijing
AU - Salanti, Georgia
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Pairwise meta-analysis is an established statistical tool for synthesizing evidence from multiple trials, but it is informative only about the relative efficacy of two specific interventions. The usefulness of pairwise meta-analysis is thus limited in real-life medical practice, where many competing interventions may be available for a certain condition and studies informing some of the pairwise comparisons may be lacking. This commonly encountered scenario has led to the development of network meta-analysis (NMA). In the last decade, several applications, methodological developments, and empirical studies in NMA have been published, and the area is thriving as its relevance to public health is increasingly recognized. This article presents a review of the relevant literature on NMA methodology aiming to pinpoint the developments that have appeared in the field.
AB - Pairwise meta-analysis is an established statistical tool for synthesizing evidence from multiple trials, but it is informative only about the relative efficacy of two specific interventions. The usefulness of pairwise meta-analysis is thus limited in real-life medical practice, where many competing interventions may be available for a certain condition and studies informing some of the pairwise comparisons may be lacking. This commonly encountered scenario has led to the development of network meta-analysis (NMA). In the last decade, several applications, methodological developments, and empirical studies in NMA have been published, and the area is thriving as its relevance to public health is increasingly recognized. This article presents a review of the relevant literature on NMA methodology aiming to pinpoint the developments that have appeared in the field.
KW - comparing multiple interventions
KW - indirect treatment comparison
KW - mixed-treatment comparison
KW - multiple-treatment meta-analysis
UR - http://www.scopus.com/inward/record.url?scp=84995758231&partnerID=8YFLogxK
U2 - 10.1002/jrsm.1195
DO - 10.1002/jrsm.1195
M3 - Article
C2 - 26754852
AN - SCOPUS:84995758231
SN - 1759-2879
VL - 7
SP - 236
EP - 263
JO - Research synthesis methods
JF - Research synthesis methods
IS - 3
ER -