Genomic correction of familial cardiomyopathy in human engineered cardiac tissues

Francesca Stillitano; Irene C. Turnbull; Ioannis Karakikes; Mathieu Nonnenmacher; Peter Backeris; Jean Sébastien Hulot; Evangelia G. Kranias; Roger J. Hajjar; Kevin D. Costa

doi:10.1093/eurheartj/ehw307

Genomic correction of familial cardiomyopathy in human engineered cardiac tissues

Francesca Stillitano
, Irene C. Turnbull
, Ioannis Karakikes
, Mathieu Nonnenmacher
, Peter Backeris
, Jean Sébastien Hulot
, Evangelia G. Kranias
, Roger J. Hajjar^*
, Kevin D. Costa

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

In this study, we used three-dimensional human engineered cardiac tissue technology to directly show that phospholamban (PLN) R14del mutation impairs cardiac contractility and to demonstrate restoration of contractile properties with targeted genetic correction of this inheritable form of dilated cardiomyopathy.

Original language	English
Pages (from-to)	3282-3284
Number of pages	3
Journal	European heart journal
Volume	37
Issue number	43
DOIs	https://doi.org/10.1093/eurheartj/ehw307
Publication status	Published - 1 Nov 2016
Externally published	Yes

Keywords

Dilated cardiomyopathy
Engineered heart tissue
Gene editing
Induced pluripotent stem cells
Phospholamban

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10.1093/eurheartj/ehw307

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title = "Genomic correction of familial cardiomyopathy in human engineered cardiac tissues",

abstract = "In this study, we used three-dimensional human engineered cardiac tissue technology to directly show that phospholamban (PLN) R14del mutation impairs cardiac contractility and to demonstrate restoration of contractile properties with targeted genetic correction of this inheritable form of dilated cardiomyopathy.",

keywords = "Dilated cardiomyopathy, Engineered heart tissue, Gene editing, Induced pluripotent stem cells, Phospholamban",

author = "Francesca Stillitano and Turnbull, \{Irene C.\} and Ioannis Karakikes and Mathieu Nonnenmacher and Peter Backeris and Hulot, \{Jean S{\'e}bastien\} and Kranias, \{Evangelia G.\} and Hajjar, \{Roger J.\} and Costa, \{Kevin D.\}",

note = "Publisher Copyright: {\textcopyright} The Author 2016.",

year = "2016",

month = nov,

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doi = "10.1093/eurheartj/ehw307",

language = "English",

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journal = "European heart journal",

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TY - JOUR

T1 - Genomic correction of familial cardiomyopathy in human engineered cardiac tissues

AU - Stillitano, Francesca

AU - Turnbull, Irene C.

AU - Karakikes, Ioannis

AU - Nonnenmacher, Mathieu

AU - Backeris, Peter

AU - Hulot, Jean Sébastien

AU - Kranias, Evangelia G.

AU - Hajjar, Roger J.

AU - Costa, Kevin D.

N1 - Publisher Copyright: © The Author 2016.

PY - 2016/11/1

Y1 - 2016/11/1

N2 - In this study, we used three-dimensional human engineered cardiac tissue technology to directly show that phospholamban (PLN) R14del mutation impairs cardiac contractility and to demonstrate restoration of contractile properties with targeted genetic correction of this inheritable form of dilated cardiomyopathy.

AB - In this study, we used three-dimensional human engineered cardiac tissue technology to directly show that phospholamban (PLN) R14del mutation impairs cardiac contractility and to demonstrate restoration of contractile properties with targeted genetic correction of this inheritable form of dilated cardiomyopathy.

KW - Dilated cardiomyopathy

KW - Engineered heart tissue

KW - Gene editing

KW - Induced pluripotent stem cells

KW - Phospholamban

UR - https://www.scopus.com/pages/publications/85013641801

U2 - 10.1093/eurheartj/ehw307

DO - 10.1093/eurheartj/ehw307

M3 - Article

C2 - 27450564

AN - SCOPUS:85013641801

SN - 0195-668X

VL - 37

SP - 3282

EP - 3284

JO - European heart journal

JF - European heart journal

IS - 43

ER -

Genomic correction of familial cardiomyopathy in human engineered cardiac tissues

Abstract

Keywords

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