TY - JOUR
T1 - Genomes and phenomes of a population of outbred rats and its progenitors
AU - Baud, Amelie
AU - Guryev, Victor
AU - Hummel, Oliver
AU - Johannesson, Martina
AU - Flint, Jonathan
AU - Hermsen, Roel
AU - Stridh, Pernilla
AU - Graham, Delyth
AU - McBride, Martin W.
AU - Foroud, Tatiana
AU - Calderari, Sophie
AU - Diez, Margarita
AU - Ockinger, Johan
AU - Beyeen, Amennai D.
AU - Gillett, Alan
AU - Abdelmagid, Nada
AU - Guerreiro-Cacais, Andre Ortlieb
AU - Jagodic, Maja
AU - Tuncel, Jonatan
AU - Norin, Ulrika
AU - Beattie, Elisabeth
AU - Huynh, Ngan
AU - Miller, William H.
AU - Koller, Daniel L.
AU - Alam, Imranul
AU - Falak, Samreen
AU - Osborne-Pellegrin, Mary
AU - Martinez-Membrives, Esther
AU - Canete, Toni
AU - Blazquez, Gloria
AU - Vicens-Costa, Elia
AU - Mont-Cardona, Carme
AU - Diaz-Moran, Sira
AU - Tobena, Adolf
AU - Zelenika, Diana
AU - Saar, Kathrin
AU - Patone, Giannino
AU - Bauerfeind, Anja
AU - Bihoreau, Marie Therese
AU - Heinig, Matthias
AU - Lee, Young Ae
AU - Rintisch, Carola
AU - Schulz, Herbert
AU - Wheeler, David A.
AU - Worley, Kim C.
AU - Muzny, Donna M.
AU - Gibbs, Richard A.
AU - Lathrop, Mark
AU - De Bruijn, Ewart
AU - Cuppen, Edwin
PY - 2014/6/10
Y1 - 2014/6/10
N2 - Finding genetic variants that contribute to phenotypic variation is one of the main challenges of modern genetics. We used an outbred population of rats (Heterogeneous Stock, HS) in a combined sequence-based and genetic mapping analysis to identify sequence variants and genes contributing to complex traits of biomedical relevance. Here we describe the sequences of the eight inbred progenitors of the HS and the variants that segregate between them. We report the genotyping of 1,407 HS rats, and the collection from 2,006 rats of 195 phenotypic measures that are relevant to models of anxiety, type 2 diabetes, hypertension and osteoporosis. We make available haplotype dosages for the 1,407 genotyped rats, since genetic mapping in the HS is best carried out by reconstructing each HS chromosome as a mosaic of the progenitor genomes. Finally, we have deposited an R object that makes it easy to incorporate our sequence data into any genetic study of HS rats. Our genetic data are available for both Rnor3.4 and Rnor5.0 rat assemblies.
AB - Finding genetic variants that contribute to phenotypic variation is one of the main challenges of modern genetics. We used an outbred population of rats (Heterogeneous Stock, HS) in a combined sequence-based and genetic mapping analysis to identify sequence variants and genes contributing to complex traits of biomedical relevance. Here we describe the sequences of the eight inbred progenitors of the HS and the variants that segregate between them. We report the genotyping of 1,407 HS rats, and the collection from 2,006 rats of 195 phenotypic measures that are relevant to models of anxiety, type 2 diabetes, hypertension and osteoporosis. We make available haplotype dosages for the 1,407 genotyped rats, since genetic mapping in the HS is best carried out by reconstructing each HS chromosome as a mosaic of the progenitor genomes. Finally, we have deposited an R object that makes it easy to incorporate our sequence data into any genetic study of HS rats. Our genetic data are available for both Rnor3.4 and Rnor5.0 rat assemblies.
UR - http://www.scopus.com/inward/record.url?scp=84940207248&partnerID=8YFLogxK
U2 - 10.1038/sdata.2014.11
DO - 10.1038/sdata.2014.11
M3 - Article
AN - SCOPUS:84940207248
SN - 2052-4463
VL - 1
JO - Scientific data
JF - Scientific data
M1 - 140011
ER -