TY - JOUR
T1 - Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease
AU - Trégouët, David-Alexandre
AU - König, Inke R
AU - Erdmann, Jeanette
AU - Munteanu, Alexandru
AU - Braund, Peter S
AU - Hall, Alistair S
AU - Grosshennig, Anika
AU - Linsel-Nitschke, Patrick
AU - Perret, Claire
AU - DeSuremain, Maylis
AU - Meitinger, Thomas
AU - Wright, Ben J
AU - Preuss, Michael
AU - Balmforth, Anthony J
AU - Ball, Stephen G
AU - Meisinger, Christa
AU - Germain, Cécile
AU - Evans, Alun
AU - Arveiler, Dominique
AU - Luc, Gérald
AU - Ruidavets, Jean-Bernard
AU - Morrison, Caroline
AU - van der Harst, Pim
AU - Schreiber, Stefan
AU - Neureuther, Katharina
AU - Schäfer, Arne
AU - Bugert, Peter
AU - El Mokhtari, Nour E
AU - Schrezenmeir, Jürgen
AU - Stark, Klaus
AU - Rubin, Diana
AU - Wichmann, H-Erich
AU - Hengstenberg, Christian
AU - Ouwehand, Willem
AU - Ziegler, Andreas
AU - Tiret, Laurence
AU - Thompson, John R
AU - Cambien, Francois
AU - Schunkert, Heribert
AU - Samani, Nilesh J
PY - 2009/3
Y1 - 2009/3
N2 - We identify the SLC22A3-LPAL2-LPA gene cluster as a strong susceptibility locus for coronary artery disease (CAD) through a genome-wide haplotype association (GWHA) study. This locus was not identified from previous genome-wide association (GWA) studies focused on univariate analyses of SNPs. The proposed approach may have wide utility for analyzing GWA data for other complex traits.
AB - We identify the SLC22A3-LPAL2-LPA gene cluster as a strong susceptibility locus for coronary artery disease (CAD) through a genome-wide haplotype association (GWHA) study. This locus was not identified from previous genome-wide association (GWA) studies focused on univariate analyses of SNPs. The proposed approach may have wide utility for analyzing GWA data for other complex traits.
KW - Apolipoprotein A-II/genetics
KW - Case-Control Studies
KW - Coronary Artery Disease/genetics
KW - Gene Frequency
KW - Genetic Predisposition to Disease
KW - Genome-Wide Association Study
KW - Haplotypes
KW - Humans
KW - Lipoprotein(a)/genetics
KW - Multigene Family
KW - Organic Cation Transport Proteins/genetics
KW - Polymorphism, Single Nucleotide
KW - Quantitative Trait Loci
KW - Risk Factors
U2 - 10.1038/ng.314
DO - 10.1038/ng.314
M3 - Article
C2 - 19198611
SN - 1061-4036
VL - 41
SP - 283
EP - 285
JO - Nature Genetics
JF - Nature Genetics
IS - 3
ER -