Genome-wide association study identifies HLA 8.1 ancestral haplotype alleles as major genetic risk factors for myositis phenotypes

F. W. Miller; W. Chen; T. P. O'Hanlon; R. G. Cooper; J. Vencovsky; L. G. Rider; K. Danko; L. R. Wedderburn; I. E. Lundberg; L. M. Pachman; A. M. Reed; S. R. Ytterberg; L. Padyukov; A. Selva-O'Callaghan; T. R. Radstake; D. A. Isenberg; H. Chinoy; W. E. R. Ollier; P. Scheet; B. Peng; A. Lee; J. Byun; J. A. Lamb; P. K. Gregersen; C. I. Amos

doi:10.1038/gene.2015.28

Genome-wide association study identifies HLA 8.1 ancestral haplotype alleles as major genetic risk factors for myositis phenotypes

F. W. Miller^*
, W. Chen
, T. P. O'Hanlon
, R. G. Cooper
, J. Vencovsky
, L. G. Rider
, K. Danko
, L. R. Wedderburn
, I. E. Lundberg
, L. M. Pachman
, A. M. Reed
, S. R. Ytterberg
, L. Padyukov
, A. Selva-O'Callaghan
, T. R. Radstake
, D. A. Isenberg
, H. Chinoy
, W. E. R. Ollier
, P. Scheet
, B. Peng

A. Lee, J. Byun, J. A. Lamb, P. K. Gregersen, C. I. Amos,

^*Corresponding author for this work

Infection & Immunity

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Autoimmune muscle diseases (myositis) comprise a group of complex phenotypes influenced by genetic and environmental factors. To identify genetic risk factors in patients of European ancestry, we conducted a genome-wide association study (GWAS) of the major myositis phenotypes in a total of 1710 cases, which included 705 adult dermatomyositis, 473 juvenile dermatomyositis, 532 polymyositis and 202 adult dermatomyositis, juvenile dermatomyositis or polymyositis patients with anti-histidyl-tRNA synthetase (anti-Jo-1) autoantibodies, and compared them with 4724 controls. Single-nucleotide polymorphisms showing strong associations (P

Original language	English
Pages (from-to)	470-480
Number of pages	11
Journal	Genes and Immunity
Volume	16
Issue number	7
DOIs	https://doi.org/10.1038/gene.2015.28
Publication status	Published - 2015

Keywords

IDIOPATHIC INFLAMMATORY MYOPATHIES
HISTOCOMPATIBILITY COMPLEX
AUTOIMMUNE-DISEASES
IMMUNE-RESPONSE
AUTOANTIBODIES
DERMATOMYOSITIS
LINKAGE
IMMUNOGENETICS
POLYMYOSITIS
PATHOGENESIS

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Miller, F. W., Chen, W., O'Hanlon, T. P., Cooper, R. G., Vencovsky, J., Rider, L. G., Danko, K., Wedderburn, L. R., Lundberg, I. E., Pachman, L. M., Reed, A. M., Ytterberg, S. R., Padyukov, L., Selva-O'Callaghan, A., Radstake, T. R., Isenberg, D. A., Chinoy, H., Ollier, W. E. R., Scheet, P. (2015). Genome-wide association study identifies HLA 8.1 ancestral haplotype alleles as major genetic risk factors for myositis phenotypes. Genes and Immunity, 16(7), 470-480. https://doi.org/10.1038/gene.2015.28

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title = "Genome-wide association study identifies HLA 8.1 ancestral haplotype alleles as major genetic risk factors for myositis phenotypes",

abstract = "Autoimmune muscle diseases (myositis) comprise a group of complex phenotypes influenced by genetic and environmental factors. To identify genetic risk factors in patients of European ancestry, we conducted a genome-wide association study (GWAS) of the major myositis phenotypes in a total of 1710 cases, which included 705 adult dermatomyositis, 473 juvenile dermatomyositis, 532 polymyositis and 202 adult dermatomyositis, juvenile dermatomyositis or polymyositis patients with anti-histidyl-tRNA synthetase (anti-Jo-1) autoantibodies, and compared them with 4724 controls. Single-nucleotide polymorphisms showing strong associations (P",

keywords = "IDIOPATHIC INFLAMMATORY MYOPATHIES, HISTOCOMPATIBILITY COMPLEX, AUTOIMMUNE-DISEASES, IMMUNE-RESPONSE, AUTOANTIBODIES, DERMATOMYOSITIS, LINKAGE, IMMUNOGENETICS, POLYMYOSITIS, PATHOGENESIS",

author = "Miller, \{F. W.\} and W. Chen and O'Hanlon, \{T. P.\} and Cooper, \{R. G.\} and J. Vencovsky and Rider, \{L. G.\} and K. Danko and Wedderburn, \{L. R.\} and Lundberg, \{I. E.\} and Pachman, \{L. M.\} and Reed, \{A. M.\} and Ytterberg, \{S. R.\} and L. Padyukov and A. Selva-O'Callaghan and Radstake, \{T. R.\} and Isenberg, \{D. A.\} and H. Chinoy and Ollier, \{W. E. R.\} and P. Scheet and B. Peng and A. Lee and J. Byun and Lamb, \{J. A.\} and Gregersen, \{P. K.\} and Amos, \{C. I.\}",

year = "2015",

doi = "10.1038/gene.2015.28",

language = "English",

volume = "16",

pages = "470--480",

journal = "Genes and Immunity",

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Miller, FW, Chen, W, O'Hanlon, TP, Cooper, RG, Vencovsky, J, Rider, LG, Danko, K, Wedderburn, LR, Lundberg, IE, Pachman, LM, Reed, AM, Ytterberg, SR, Padyukov, L, Selva-O'Callaghan, A, Radstake, TR, Isenberg, DA, Chinoy, H, Ollier, WER, Scheet, P, Peng, B, Lee, A, Byun, J, Lamb, JA, Gregersen, PK, Amos, CI 2015, 'Genome-wide association study identifies HLA 8.1 ancestral haplotype alleles as major genetic risk factors for myositis phenotypes', Genes and Immunity, vol. 16, no. 7, pp. 470-480. https://doi.org/10.1038/gene.2015.28

TY - JOUR

T1 - Genome-wide association study identifies HLA 8.1 ancestral haplotype alleles as major genetic risk factors for myositis phenotypes

AU - Miller, F. W.

AU - Chen, W.

AU - O'Hanlon, T. P.

AU - Cooper, R. G.

AU - Vencovsky, J.

AU - Rider, L. G.

AU - Danko, K.

AU - Wedderburn, L. R.

AU - Lundberg, I. E.

AU - Pachman, L. M.

AU - Reed, A. M.

AU - Ytterberg, S. R.

AU - Padyukov, L.

AU - Selva-O'Callaghan, A.

AU - Radstake, T. R.

AU - Isenberg, D. A.

AU - Chinoy, H.

AU - Ollier, W. E. R.

AU - Scheet, P.

AU - Peng, B.

AU - Lee, A.

AU - Byun, J.

AU - Lamb, J. A.

AU - Gregersen, P. K.

AU - Amos, C. I.

PY - 2015

Y1 - 2015

N2 - Autoimmune muscle diseases (myositis) comprise a group of complex phenotypes influenced by genetic and environmental factors. To identify genetic risk factors in patients of European ancestry, we conducted a genome-wide association study (GWAS) of the major myositis phenotypes in a total of 1710 cases, which included 705 adult dermatomyositis, 473 juvenile dermatomyositis, 532 polymyositis and 202 adult dermatomyositis, juvenile dermatomyositis or polymyositis patients with anti-histidyl-tRNA synthetase (anti-Jo-1) autoantibodies, and compared them with 4724 controls. Single-nucleotide polymorphisms showing strong associations (P

AB - Autoimmune muscle diseases (myositis) comprise a group of complex phenotypes influenced by genetic and environmental factors. To identify genetic risk factors in patients of European ancestry, we conducted a genome-wide association study (GWAS) of the major myositis phenotypes in a total of 1710 cases, which included 705 adult dermatomyositis, 473 juvenile dermatomyositis, 532 polymyositis and 202 adult dermatomyositis, juvenile dermatomyositis or polymyositis patients with anti-histidyl-tRNA synthetase (anti-Jo-1) autoantibodies, and compared them with 4724 controls. Single-nucleotide polymorphisms showing strong associations (P

KW - IDIOPATHIC INFLAMMATORY MYOPATHIES

KW - HISTOCOMPATIBILITY COMPLEX

KW - AUTOIMMUNE-DISEASES

KW - IMMUNE-RESPONSE

KW - AUTOANTIBODIES

KW - DERMATOMYOSITIS

KW - LINKAGE

KW - IMMUNOGENETICS

KW - POLYMYOSITIS

KW - PATHOGENESIS

U2 - 10.1038/gene.2015.28

DO - 10.1038/gene.2015.28

M3 - Article

C2 - 26291516

SN - 1466-4879

VL - 16

SP - 470

EP - 480

JO - Genes and Immunity

JF - Genes and Immunity

IS - 7

ER -

Genome-wide association study identifies HLA 8.1 ancestral haplotype alleles as major genetic risk factors for myositis phenotypes

Abstract

Keywords

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