Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia.

Q. Lan; C.A. Hsiung; K. Matsuo; Y.C. Hong; A. Seow; Z. Wang; H.D. Hosgood; K. Chen; J.C. Wang; N. Chatterjee; W. Hu; M.P. Wong; W. Zheng; N. Caporaso; J.Y. Park; C.J. Chen; Y.H. Kim; Y.T. Kim; M.T. Landi; H. Shen; C. Lawrence; L. Burdett; M. Yeager; J. Yuenger; K.B. Jacobs; I.S. Chang; T. Mitsudomi; H.N. Kim; G.C. Chang; B.A. Bassig; M. Tucker; F. Wei; Y. Yin; C. Wu; S.J. An; B. Qian; V.H. Lee; D. Lu; J. Liu; H.S. Jeon; C.F. Hsiao; J.S. Sung; J.H. Kim; Y.T. Gao; Y.H. Tsai; Y.J. Jung; H. Guo; Z. Hu; A. Hutchinson; W.C. Wang; R. Klein; C.C. Chung; I.J. Oh; K.Y. Chen; S.I. Berndt; X. He; W. Wu; J. Chang; X.C. Zhang; M.S. Huang; H. Zheng; J. Wang; X. Zhao; Y. Li; J.E. Choi; W.C. Su; K.H. Park; S.W. Sung; X.O. Shu; Y.M. Chen; L. Liu; C.H. Kang; L. Hu; C.H. Chen; W. Pao; Y.C. Kim; T.Y. Yang; J. Xu; P. Guan; W. Tan; J. Su; C.L. Wang; H. Li; A.D. Sihoe; Z. Zhao; Y. Chen; Y.Y. Choi; J.Y. Hung; J.S. Kim; H.I. Yoon; Q. Cai; C.C. Lin; I.K. Park; P. Xu; J. Dong; C. Kim; Q He; R.P. Perng; T. Kohno; S.S. Kweon; C.Y. Chen; R. Vermeulen; J. Wu; W.Y. Lim; K.C. Chen; W.H. Chow; B.T. Ji; J.K. Chan; M. Chu; Y.J. Li; J. Yokota; J. Li; H. Chen; Y.B. Xiang; C.J. Yu; H. Kunitoh; G. Wu; L. Jin; Y.L. Lo; K. Shiraishi; Y.H. Chen; H.C. Lin; T. Wu; Y. WU; P.C. Yang; B. Zhou; M.H. Shin; J.F. Fraumeni; D. Lin; S.J. Chanock; N. Rothman

doi:10.1038/ng.2456

Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia.

Translated title of the contribution: Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia.

Q. Lan, C.A. Hsiung, K. Matsuo, Y.C. Hong, A. Seow, Z. Wang, H.D. Hosgood, K. Chen, J.C. Wang, N. Chatterjee, W. Hu, M.P. Wong, W. Zheng, N. Caporaso, J.Y. Park, C.J. Chen, Y.H. Kim, Y.T. Kim, M.T. Landi, H. ShenC. Lawrence, L. Burdett, M. Yeager, J. Yuenger, K.B. Jacobs, I.S. Chang, T. Mitsudomi, H.N. Kim, G.C. Chang, B.A. Bassig, M. Tucker, F. Wei, Y. Yin, C. Wu, S.J. An, B. Qian, V.H. Lee, D. Lu, J. Liu, H.S. Jeon, C.F. Hsiao, J.S. Sung, J.H. Kim, Y.T. Gao, Y.H. Tsai, Y.J. Jung, H. Guo, Z. Hu, A. Hutchinson, W.C. Wang, R. Klein, C.C. Chung, I.J. Oh, K.Y. Chen, S.I. Berndt, X. He, W. Wu, J. Chang, X.C. Zhang, M.S. Huang, H. Zheng, J. Wang, X. Zhao, Y. Li, J.E. Choi, W.C. Su, K.H. Park, S.W. Sung, X.O. Shu, Y.M. Chen, L. Liu, C.H. Kang, L. Hu, C.H. Chen, W. Pao, Y.C. Kim, T.Y. Yang, J. Xu, P. Guan, W. Tan, J. Su, C.L. Wang, H. Li, A.D. Sihoe, Z. Zhao, Y. Chen, Y.Y. Choi, J.Y. Hung, J.S. Kim, H.I. Yoon, Q. Cai, C.C. Lin, I.K. Park, P. Xu, J. Dong, C. Kim, Q He, R.P. Perng, T. Kohno, S.S. Kweon, C.Y. Chen, R. Vermeulen, J. Wu, W.Y. Lim, K.C. Chen, W.H. Chow, B.T. Ji, J.K. Chan, M. Chu, Y.J. Li, J. Yokota, J. Li, H. Chen, Y.B. Xiang, C.J. Yu, H. Kunitoh, G. Wu, L. Jin, Y.L. Lo, K. Shiraishi, Y.H. Chen, H.C. Lin, T. Wu, Y. WU, P.C. Yang, B. Zhou, M.H. Shin, J.F. Fraumeni, D. Lin, S.J. Chanock, N. Rothman

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

To identify common genetic variants that contribute to lung cancer susceptibility, we conducted a multistage genome-wide association study of lung cancer in Asian women who never smoked. We scanned 5,510 never-smoking female lung cancer cases and 4,544 controls drawn from 14 studies from mainland China, South Korea, Japan, Singapore, Taiwan and Hong Kong. We genotyped the most promising variants (associated at P <5 x 10(-6)) in an additional 1,099 cases and 2,913 controls. We identified three new susceptibility loci at 10q25.2 (rs7086803, P = 3.54 x 10(-18)), 6q22.2 (rs9387478, P = 4.14 x 10(-10)) and 6p21.32 (rs2395185, P = 9.51 x 10(-9)). We also confirmed associations reported for loci at 5p15.33 and 3q28 and a recently reported finding at 17q24.3. We observed no evidence of association for lung cancer at 15q25 in never-smoking women in Asia, providing strong evidence that this locus is not associated with lung cancer independent of smoking.

Translated title of the contribution	Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia.
Original language	Undefined/Unknown
Pages (from-to)	1330-1335
Number of pages	6
Journal	Nature Genetics
Volume	44
Issue number	12
DOIs	https://doi.org/10.1038/ng.2456
Publication status	Published - 2012

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Lan, Q., Hsiung, C. A., Matsuo, K., Hong, Y. C., Seow, A., Wang, Z., Hosgood, H. D., Chen, K., Wang, J. C., Chatterjee, N., Hu, W., Wong, M. P., Zheng, W., Caporaso, N., Park, J. Y., Chen, C. J., Kim, Y. H., Kim, Y. T., Landi, M. T., ... Rothman, N. (2012). Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia. Nature Genetics, 44(12), 1330-1335. https://doi.org/10.1038/ng.2456

@article{eb416e1952e24451bbe76dd035afa157,

title = "Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia.",

abstract = "To identify common genetic variants that contribute to lung cancer susceptibility, we conducted a multistage genome-wide association study of lung cancer in Asian women who never smoked. We scanned 5,510 never-smoking female lung cancer cases and 4,544 controls drawn from 14 studies from mainland China, South Korea, Japan, Singapore, Taiwan and Hong Kong. We genotyped the most promising variants (associated at P <5 x 10(-6)) in an additional 1,099 cases and 2,913 controls. We identified three new susceptibility loci at 10q25.2 (rs7086803, P = 3.54 x 10(-18)), 6q22.2 (rs9387478, P = 4.14 x 10(-10)) and 6p21.32 (rs2395185, P = 9.51 x 10(-9)). We also confirmed associations reported for loci at 5p15.33 and 3q28 and a recently reported finding at 17q24.3. We observed no evidence of association for lung cancer at 15q25 in never-smoking women in Asia, providing strong evidence that this locus is not associated with lung cancer independent of smoking.",

author = "Q. Lan and C.A. Hsiung and K. Matsuo and Y.C. Hong and A. Seow and Z. Wang and H.D. Hosgood and K. Chen and J.C. Wang and N. Chatterjee and W. Hu and M.P. Wong and W. Zheng and N. Caporaso and J.Y. Park and C.J. Chen and Y.H. Kim and Y.T. Kim and M.T. Landi and H. Shen and C. Lawrence and L. Burdett and M. Yeager and J. Yuenger and K.B. Jacobs and I.S. Chang and T. Mitsudomi and H.N. Kim and G.C. Chang and B.A. Bassig and M. Tucker and F. Wei and Y. Yin and C. Wu and S.J. An and B. Qian and V.H. Lee and D. Lu and J. Liu and H.S. Jeon and C.F. Hsiao and J.S. Sung and J.H. Kim and Y.T. Gao and Y.H. Tsai and Y.J. Jung and H. Guo and Z. Hu and A. Hutchinson and W.C. Wang and R. Klein and C.C. Chung and I.J. Oh and K.Y. Chen and S.I. Berndt and X. He and W. Wu and J. Chang and X.C. Zhang and M.S. Huang and H. Zheng and J. Wang and X. Zhao and Y. Li and J.E. Choi and W.C. Su and K.H. Park and S.W. Sung and X.O. Shu and Y.M. Chen and L. Liu and C.H. Kang and L. Hu and C.H. Chen and W. Pao and Y.C. Kim and T.Y. Yang and J. Xu and P. Guan and W. Tan and J. Su and C.L. Wang and H. Li and A.D. Sihoe and Z. Zhao and Y. Chen and Y.Y. Choi and J.Y. Hung and J.S. Kim and H.I. Yoon and Q. Cai and C.C. Lin and I.K. Park and P. Xu and J. Dong and C. Kim and Q He and R.P. Perng and T. Kohno and S.S. Kweon and C.Y. Chen and R. Vermeulen and J. Wu and W.Y. Lim and K.C. Chen and W.H. Chow and B.T. Ji and J.K. Chan and M. Chu and Y.J. Li and J. Yokota and J. Li and H. Chen and Y.B. Xiang and C.J. Yu and H. Kunitoh and G. Wu and L. Jin and Y.L. Lo and K. Shiraishi and Y.H. Chen and H.C. Lin and T. Wu and Y. WU and P.C. Yang and B. Zhou and M.H. Shin and J.F. Fraumeni and D. Lin and S.J. Chanock and N. Rothman",

year = "2012",

doi = "10.1038/ng.2456",

language = "Undefined/Unknown",

volume = "44",

pages = "1330--1335",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Research",

number = "12",

}

Lan, Q, Hsiung, CA, Matsuo, K, Hong, YC, Seow, A, Wang, Z, Hosgood, HD, Chen, K, Wang, JC, Chatterjee, N, Hu, W, Wong, MP, Zheng, W, Caporaso, N, Park, JY, Chen, CJ, Kim, YH, Kim, YT, Landi, MT, Shen, H, Lawrence, C, Burdett, L, Yeager, M, Yuenger, J, Jacobs, KB, Chang, IS, Mitsudomi, T, Kim, HN, Chang, GC, Bassig, BA, Tucker, M, Wei, F, Yin, Y, Wu, C, An, SJ, Qian, B, Lee, VH, Lu, D, Liu, J, Jeon, HS, Hsiao, CF, Sung, JS, Kim, JH, Gao, YT, Tsai, YH, Jung, YJ, Guo, H, Hu, Z, Hutchinson, A, Wang, WC, Klein, R, Chung, CC, Oh, IJ, Chen, KY, Berndt, SI, He, X, Wu, W, Chang, J, Zhang, XC, Huang, MS, Zheng, H, Wang, J, Zhao, X, Li, Y, Choi, JE, Su, WC, Park, KH, Sung, SW, Shu, XO, Chen, YM, Liu, L, Kang, CH, Hu, L, Chen, CH, Pao, W, Kim, YC, Yang, TY, Xu, J, Guan, P, Tan, W, Su, J, Wang, CL, Li, H, Sihoe, AD, Zhao, Z, Chen, Y, Choi, YY, Hung, JY, Kim, JS, Yoon, HI, Cai, Q, Lin, CC, Park, IK, Xu, P, Dong, J, Kim, C, He, Q, Perng, RP, Kohno, T, Kweon, SS, Chen, CY, Vermeulen, R, Wu, J, Lim, WY, Chen, KC, Chow, WH, Ji, BT, Chan, JK, Chu, M, Li, YJ, Yokota, J, Li, J, Chen, H, Xiang, YB, Yu, CJ, Kunitoh, H, Wu, G, Jin, L, Lo, YL, Shiraishi, K, Chen, YH, Lin, HC, Wu, T, WU, Y, Yang, PC, Zhou, B, Shin, MH, Fraumeni, JF, Lin, D, Chanock, SJ & Rothman, N 2012, 'Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia.', Nature Genetics, vol. 44, no. 12, pp. 1330-1335. https://doi.org/10.1038/ng.2456

TY - JOUR

T1 - Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia.

AU - Lan, Q.

AU - Hsiung, C.A.

AU - Matsuo, K.

AU - Hong, Y.C.

AU - Seow, A.

AU - Wang, Z.

AU - Hosgood, H.D.

AU - Chen, K.

AU - Wang, J.C.

AU - Chatterjee, N.

AU - Hu, W.

AU - Wong, M.P.

AU - Zheng, W.

AU - Caporaso, N.

AU - Park, J.Y.

AU - Chen, C.J.

AU - Kim, Y.H.

AU - Kim, Y.T.

AU - Landi, M.T.

AU - Shen, H.

AU - Lawrence, C.

AU - Burdett, L.

AU - Yeager, M.

AU - Yuenger, J.

AU - Jacobs, K.B.

AU - Chang, I.S.

AU - Mitsudomi, T.

AU - Kim, H.N.

AU - Chang, G.C.

AU - Bassig, B.A.

AU - Tucker, M.

AU - Wei, F.

AU - Yin, Y.

AU - Wu, C.

AU - An, S.J.

AU - Qian, B.

AU - Lee, V.H.

AU - Lu, D.

AU - Liu, J.

AU - Jeon, H.S.

AU - Hsiao, C.F.

AU - Sung, J.S.

AU - Kim, J.H.

AU - Gao, Y.T.

AU - Tsai, Y.H.

AU - Jung, Y.J.

AU - Guo, H.

AU - Hu, Z.

AU - Hutchinson, A.

AU - Wang, W.C.

AU - Klein, R.

AU - Chung, C.C.

AU - Oh, I.J.

AU - Chen, K.Y.

AU - Berndt, S.I.

AU - He, X.

AU - Wu, W.

AU - Chang, J.

AU - Zhang, X.C.

AU - Huang, M.S.

AU - Zheng, H.

AU - Wang, J.

AU - Zhao, X.

AU - Li, Y.

AU - Choi, J.E.

AU - Su, W.C.

AU - Park, K.H.

AU - Sung, S.W.

AU - Shu, X.O.

AU - Chen, Y.M.

AU - Liu, L.

AU - Kang, C.H.

AU - Hu, L.

AU - Chen, C.H.

AU - Pao, W.

AU - Kim, Y.C.

AU - Yang, T.Y.

AU - Xu, J.

AU - Guan, P.

AU - Tan, W.

AU - Su, J.

AU - Wang, C.L.

AU - Li, H.

AU - Sihoe, A.D.

AU - Zhao, Z.

AU - Chen, Y.

AU - Choi, Y.Y.

AU - Hung, J.Y.

AU - Kim, J.S.

AU - Yoon, H.I.

AU - Cai, Q.

AU - Lin, C.C.

AU - Park, I.K.

AU - Xu, P.

AU - Dong, J.

AU - Kim, C.

AU - He, Q

AU - Perng, R.P.

AU - Kohno, T.

AU - Kweon, S.S.

AU - Chen, C.Y.

AU - Vermeulen, R.

AU - Wu, J.

AU - Lim, W.Y.

AU - Chen, K.C.

AU - Chow, W.H.

AU - Ji, B.T.

AU - Chan, J.K.

AU - Chu, M.

AU - Li, Y.J.

AU - Yokota, J.

AU - Li, J.

AU - Chen, H.

AU - Xiang, Y.B.

AU - Yu, C.J.

AU - Kunitoh, H.

AU - Wu, G.

AU - Jin, L.

AU - Lo, Y.L.

AU - Shiraishi, K.

AU - Chen, Y.H.

AU - Lin, H.C.

AU - Wu, T.

AU - WU, Y.

AU - Yang, P.C.

AU - Zhou, B.

AU - Shin, M.H.

AU - Fraumeni, J.F.

AU - Lin, D.

AU - Chanock, S.J.

AU - Rothman, N.

PY - 2012

Y1 - 2012

N2 - To identify common genetic variants that contribute to lung cancer susceptibility, we conducted a multistage genome-wide association study of lung cancer in Asian women who never smoked. We scanned 5,510 never-smoking female lung cancer cases and 4,544 controls drawn from 14 studies from mainland China, South Korea, Japan, Singapore, Taiwan and Hong Kong. We genotyped the most promising variants (associated at P <5 x 10(-6)) in an additional 1,099 cases and 2,913 controls. We identified three new susceptibility loci at 10q25.2 (rs7086803, P = 3.54 x 10(-18)), 6q22.2 (rs9387478, P = 4.14 x 10(-10)) and 6p21.32 (rs2395185, P = 9.51 x 10(-9)). We also confirmed associations reported for loci at 5p15.33 and 3q28 and a recently reported finding at 17q24.3. We observed no evidence of association for lung cancer at 15q25 in never-smoking women in Asia, providing strong evidence that this locus is not associated with lung cancer independent of smoking.

AB - To identify common genetic variants that contribute to lung cancer susceptibility, we conducted a multistage genome-wide association study of lung cancer in Asian women who never smoked. We scanned 5,510 never-smoking female lung cancer cases and 4,544 controls drawn from 14 studies from mainland China, South Korea, Japan, Singapore, Taiwan and Hong Kong. We genotyped the most promising variants (associated at P <5 x 10(-6)) in an additional 1,099 cases and 2,913 controls. We identified three new susceptibility loci at 10q25.2 (rs7086803, P = 3.54 x 10(-18)), 6q22.2 (rs9387478, P = 4.14 x 10(-10)) and 6p21.32 (rs2395185, P = 9.51 x 10(-9)). We also confirmed associations reported for loci at 5p15.33 and 3q28 and a recently reported finding at 17q24.3. We observed no evidence of association for lung cancer at 15q25 in never-smoking women in Asia, providing strong evidence that this locus is not associated with lung cancer independent of smoking.

U2 - 10.1038/ng.2456

DO - 10.1038/ng.2456

M3 - Article

C2 - 23143601

SN - 1061-4036

VL - 44

SP - 1330

EP - 1335

JO - Nature Genetics

JF - Nature Genetics

IS - 12

ER -

Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia.

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