Genetics of preeclampsia: Paradigm shifts

Cees B.M. Oudejans; Marie Dijk; Marjet Oosterkamp; Augusta Lachmeijer; Marinus A. Blankenstein

doi:10.1007/s00439-006-0259-1

Genetics of preeclampsia: Paradigm shifts

Cees B.M. Oudejans^*, Marie Dijk, Marjet Oosterkamp, Augusta Lachmeijer, Marinus A. Blankenstein

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Segregation of preeclampsia into early-onset, placental and late-onset, maternal subtypes along with the acknowledgement of the contribution of epigenetics in placentally expressed genes proved to be a key first step in the identification of essential gene variants associated with preeclampsia. Application of this insight to other populations and related pregnancy-induced syndromes, such as HELLP, and acknowledgment of the features shared between chromosomal loci associated with preeclampsia in different populations provide the rationale for new strategies for the identification of susceptibility genes and for new and more effective diagnostic strategies.

Original language	English
Pages (from-to)	607-612
Number of pages	6
Journal	Human Genetics
Volume	120
Issue number	5
DOIs	https://doi.org/10.1007/s00439-006-0259-1
Publication status	Published - Jan 2007
Externally published	Yes

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title = "Genetics of preeclampsia: Paradigm shifts",

abstract = "Segregation of preeclampsia into early-onset, placental and late-onset, maternal subtypes along with the acknowledgement of the contribution of epigenetics in placentally expressed genes proved to be a key first step in the identification of essential gene variants associated with preeclampsia. Application of this insight to other populations and related pregnancy-induced syndromes, such as HELLP, and acknowledgment of the features shared between chromosomal loci associated with preeclampsia in different populations provide the rationale for new strategies for the identification of susceptibility genes and for new and more effective diagnostic strategies.",

author = "Oudejans, {Cees B.M.} and Marie Dijk and Marjet Oosterkamp and Augusta Lachmeijer and Blankenstein, {Marinus A.}",

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language = "English",

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T2 - Paradigm shifts

AU - Oudejans, Cees B.M.

AU - Dijk, Marie

AU - Oosterkamp, Marjet

AU - Lachmeijer, Augusta

AU - Blankenstein, Marinus A.

PY - 2007/1

Y1 - 2007/1

N2 - Segregation of preeclampsia into early-onset, placental and late-onset, maternal subtypes along with the acknowledgement of the contribution of epigenetics in placentally expressed genes proved to be a key first step in the identification of essential gene variants associated with preeclampsia. Application of this insight to other populations and related pregnancy-induced syndromes, such as HELLP, and acknowledgment of the features shared between chromosomal loci associated with preeclampsia in different populations provide the rationale for new strategies for the identification of susceptibility genes and for new and more effective diagnostic strategies.

AB - Segregation of preeclampsia into early-onset, placental and late-onset, maternal subtypes along with the acknowledgement of the contribution of epigenetics in placentally expressed genes proved to be a key first step in the identification of essential gene variants associated with preeclampsia. Application of this insight to other populations and related pregnancy-induced syndromes, such as HELLP, and acknowledgment of the features shared between chromosomal loci associated with preeclampsia in different populations provide the rationale for new strategies for the identification of susceptibility genes and for new and more effective diagnostic strategies.

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U2 - 10.1007/s00439-006-0259-1

DO - 10.1007/s00439-006-0259-1

M3 - Review article

C2 - 17024365

AN - SCOPUS:33845619984

SN - 0340-6717

VL - 120

SP - 607

EP - 612

JO - Human Genetics

JF - Human Genetics

IS - 5

ER -

Genetics of preeclampsia: Paradigm shifts

Abstract

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