Genetics of Intracranial Aneurysms

Mark K. Bakker; Ynte M. Ruigrok

doi:10.1161/STROKEAHA.120.032621

Genetics of Intracranial Aneurysms

Mark K. Bakker, Ynte M. Ruigrok^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

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Abstract

Rupture of an intracranial aneurysm leads to aneurysmal subarachnoid hemorrhage, a severe type of stroke which is, in part, driven by genetic variation. In the past 10 years, genetic studies of IA have boosted the number of known genetic risk factors and improved our understanding of the disease. In this review, we provide an overview of the current status of the field and highlight the latest findings of family based, sequencing, and genome-wide association studies. We further describe opportunities of genetic analyses for understanding, prevention, and treatment of the disease.

Original language	English
Pages (from-to)	3004-3012
Number of pages	9
Journal	Stroke
Volume	52
Issue number	9
DOIs	https://doi.org/10.1161/STROKEAHA.120.032621
Publication status	Published - 1 Sept 2021

Keywords

Aneurysm, Ruptured/genetics
Genetic Predisposition to Disease/genetics
Genome-Wide Association Study/methods
Humans
Intracranial Aneurysm/genetics
Risk Factors
Subarachnoid Hemorrhage/genetics

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10.1161/STROKEAHA.120.032621

20210209_Review_IAgenetics_revised_clean_ACCEPTEDVERSION_figAccepted author manuscript, 546 KB

https://dspace.library.uu.nl/handle/1874/422354

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title = "Genetics of Intracranial Aneurysms",

abstract = "Rupture of an intracranial aneurysm leads to aneurysmal subarachnoid hemorrhage, a severe type of stroke which is, in part, driven by genetic variation. In the past 10 years, genetic studies of IA have boosted the number of known genetic risk factors and improved our understanding of the disease. In this review, we provide an overview of the current status of the field and highlight the latest findings of family based, sequencing, and genome-wide association studies. We further describe opportunities of genetic analyses for understanding, prevention, and treatment of the disease.",

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AU - Ruigrok, Ynte M.

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N2 - Rupture of an intracranial aneurysm leads to aneurysmal subarachnoid hemorrhage, a severe type of stroke which is, in part, driven by genetic variation. In the past 10 years, genetic studies of IA have boosted the number of known genetic risk factors and improved our understanding of the disease. In this review, we provide an overview of the current status of the field and highlight the latest findings of family based, sequencing, and genome-wide association studies. We further describe opportunities of genetic analyses for understanding, prevention, and treatment of the disease.

AB - Rupture of an intracranial aneurysm leads to aneurysmal subarachnoid hemorrhage, a severe type of stroke which is, in part, driven by genetic variation. In the past 10 years, genetic studies of IA have boosted the number of known genetic risk factors and improved our understanding of the disease. In this review, we provide an overview of the current status of the field and highlight the latest findings of family based, sequencing, and genome-wide association studies. We further describe opportunities of genetic analyses for understanding, prevention, and treatment of the disease.

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KW - Genome-Wide Association Study/methods

KW - Humans

KW - Intracranial Aneurysm/genetics

KW - Risk Factors

KW - Subarachnoid Hemorrhage/genetics

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SP - 3004

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JO - Stroke

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Genetics of Intracranial Aneurysms

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