TY - JOUR
T1 - Genetic variation within the Y chromosome is not associated with histological characteristics of the atherosclerotic carotid artery or aneurysmal wall
AU - Haitjema, Saskia
AU - van Setten, Jessica
AU - Eales, James
AU - van der Laan, Sander W
AU - Gandin, Ilaria
AU - de Vries, Jean-Paul P M
AU - de Borst, Gert J
AU - Pasterkamp, Gerard
AU - Asselbergs, Folkert W
AU - Charchar, Fadi J
AU - Wilson, James F
AU - de Jager, Saskia C A
AU - Tomaszewski, Maciej
AU - den Ruijter, Hester M
N1 - Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2017/4
Y1 - 2017/4
N2 - BACKGROUND AND AIMS: Haplogroup I, a common European paternal lineage of the Y chromosome, is associated with increased risk of coronary artery disease in British men. It is unclear whether this haplogroup or any other haplogroup on the Y chromosome is associated with histological characteristics of the diseased vessel wall in other vascular manifestations of cardiovascular diseases showing a male preponderance.METHODS: We examined Dutch men undergoing either carotid endarterectomy from the Athero-Express biobank (AE, n = 1217) or open aneurysm repair from the Aneurysm-Express biobank (AAA, n = 393). Upon resolving the Y chromosome phylogeny, each man was assigned to one of the paternal lineages based on combinations of single nucleotide polymorphisms of the male-specific region of the Y chromosome. We examined the associations between the Y chromosome and the histological characteristics of the carotid plaque and aneurysm wall, including lipid content, leukocyte infiltration and intraplaque haemorrhage, in all men.RESULTS: A majority of men were carriers of either haplogroup I (AE: 28% AAA: 24%) or haplogroup R (AE: 59% AAA: 61%). We found no association between Y chromosomal haplogroups and histological characteristics of plaque collected from carotid arteries or tissue specimens of aneurysms. Moreover, the distribution of frequency for all Y chromosomal haplogroups in both cohorts was similar to that of a general population of Dutch men.CONCLUSIONS: Our data show that genetic variation on the Y chromosome is not associated with histological characteristics of the plaques from carotid arteries or specimens of aneurysms in men of Dutch origin.
AB - BACKGROUND AND AIMS: Haplogroup I, a common European paternal lineage of the Y chromosome, is associated with increased risk of coronary artery disease in British men. It is unclear whether this haplogroup or any other haplogroup on the Y chromosome is associated with histological characteristics of the diseased vessel wall in other vascular manifestations of cardiovascular diseases showing a male preponderance.METHODS: We examined Dutch men undergoing either carotid endarterectomy from the Athero-Express biobank (AE, n = 1217) or open aneurysm repair from the Aneurysm-Express biobank (AAA, n = 393). Upon resolving the Y chromosome phylogeny, each man was assigned to one of the paternal lineages based on combinations of single nucleotide polymorphisms of the male-specific region of the Y chromosome. We examined the associations between the Y chromosome and the histological characteristics of the carotid plaque and aneurysm wall, including lipid content, leukocyte infiltration and intraplaque haemorrhage, in all men.RESULTS: A majority of men were carriers of either haplogroup I (AE: 28% AAA: 24%) or haplogroup R (AE: 59% AAA: 61%). We found no association between Y chromosomal haplogroups and histological characteristics of plaque collected from carotid arteries or tissue specimens of aneurysms. Moreover, the distribution of frequency for all Y chromosomal haplogroups in both cohorts was similar to that of a general population of Dutch men.CONCLUSIONS: Our data show that genetic variation on the Y chromosome is not associated with histological characteristics of the plaques from carotid arteries or specimens of aneurysms in men of Dutch origin.
KW - Aneurysm
KW - Carotid endarterectomy
KW - Haplogroups
KW - Histology
KW - Men
KW - Plaque characteristics
KW - Y chromosome
UR - http://www.scopus.com/inward/record.url?scp=85013632220&partnerID=8YFLogxK
U2 - 10.1016/j.atherosclerosis.2017.02.011
DO - 10.1016/j.atherosclerosis.2017.02.011
M3 - Article
C2 - 28238413
SN - 0021-9150
VL - 259
SP - 114
EP - 119
JO - Atherosclerosis
JF - Atherosclerosis
ER -