Genetic variation of the 5-HT(2A) receptor gene and bipolar affective disorder

Blanca Gutiérrez; Jaume Bertranpetit; David Collier; María J. Arranz; Vicenç Vallès; Roser Guillamat; Jim Van Os; Lourdes Fañanás

doi:10.1007/s004390050556

Genetic variation of the 5-HT(2A) receptor gene and bipolar affective disorder

Blanca Gutiérrez, Jaume Bertranpetit, David Collier, María J. Arranz, Vicenç Vallès, Roser Guillamat, Jim Van Os, Lourdes Fañanás^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

44 Citations (Scopus)

Abstract

Abnormalities of the serotonergic system have classically been associated with the origin of affective disorders through the biochemical action of therapeutic agents and their role in affective and perceptual states. In the present study, we hypothesized that genetic variation in the 5-hydroxytryptamine (serotonin) type 2A (5-HT(2A)) receptor gene (HTR2A) might have an effect on the aetiology of bipolar affective disorder. Four different polymorphisms in the HTR2A gene were studied in 88 patients with bipolar affective disorder and 113 healthy controls, all of Spanish origin. No significant association was observed between any of the four polymorphisms at the HTR2A locus, whether tested individually or as haplotypes, and bipolar affective disorder. The lack of association suggests that HTR2A is not a major risk factor for bipolar affective disorder.

Original language	English
Pages (from-to)	582-584
Number of pages	3
Journal	Human Genetics
Volume	100
Issue number	5-6
DOIs	https://doi.org/10.1007/s004390050556
Publication status	Published - 1997
Externally published	Yes

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title = "Genetic variation of the 5-HT(2A) receptor gene and bipolar affective disorder",

abstract = "Abnormalities of the serotonergic system have classically been associated with the origin of affective disorders through the biochemical action of therapeutic agents and their role in affective and perceptual states. In the present study, we hypothesized that genetic variation in the 5-hydroxytryptamine (serotonin) type 2A (5-HT(2A)) receptor gene (HTR2A) might have an effect on the aetiology of bipolar affective disorder. Four different polymorphisms in the HTR2A gene were studied in 88 patients with bipolar affective disorder and 113 healthy controls, all of Spanish origin. No significant association was observed between any of the four polymorphisms at the HTR2A locus, whether tested individually or as haplotypes, and bipolar affective disorder. The lack of association suggests that HTR2A is not a major risk factor for bipolar affective disorder.",

author = "Blanca Guti{\'e}rrez and Jaume Bertranpetit and David Collier and Arranz, {Mar{\'i}a J.} and Vicen{\c c} Vall{\`e}s and Roser Guillamat and {Van Os}, Jim and Lourdes Fa{\~n}an{\'a}s",

note = "Funding Information: Acknowledgements This work was supported by a grant from “Ministerio de Educaci{\'o}n y Ciencia” and The British Council (project 100B) to Lourdes Fa{\~n}an{\'a}s and Jim Van Os and two grants by “Direcci{\'o}n General de Investigaci{\'o}n Cient{\'i}fica y T{\'e}cnica” (PB92-0722 and PB95-0267-C02-01) to Jaume Bertranpetit. The contribution of Carlos Torrico (Institut de Recerca Oncol{\`o}gica) is gratefully acknowledged. We are grateful to the HGMP Resource Centre, Hinxton Hall, Cambridgeshire, for the provision of oligonucleotide primers for this research.",

year = "1997",

doi = "10.1007/s004390050556",

language = "English",

volume = "100",

pages = "582--584",

journal = "Human Genetics",

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AU - Gutiérrez, Blanca

AU - Bertranpetit, Jaume

AU - Collier, David

AU - Arranz, María J.

AU - Vallès, Vicenç

AU - Guillamat, Roser

AU - Van Os, Jim

AU - Fañanás, Lourdes

N1 - Funding Information: Acknowledgements This work was supported by a grant from “Ministerio de Educación y Ciencia” and The British Council (project 100B) to Lourdes Fañanás and Jim Van Os and two grants by “Dirección General de Investigación Científica y Técnica” (PB92-0722 and PB95-0267-C02-01) to Jaume Bertranpetit. The contribution of Carlos Torrico (Institut de Recerca Oncològica) is gratefully acknowledged. We are grateful to the HGMP Resource Centre, Hinxton Hall, Cambridgeshire, for the provision of oligonucleotide primers for this research.

PY - 1997

Y1 - 1997

N2 - Abnormalities of the serotonergic system have classically been associated with the origin of affective disorders through the biochemical action of therapeutic agents and their role in affective and perceptual states. In the present study, we hypothesized that genetic variation in the 5-hydroxytryptamine (serotonin) type 2A (5-HT(2A)) receptor gene (HTR2A) might have an effect on the aetiology of bipolar affective disorder. Four different polymorphisms in the HTR2A gene were studied in 88 patients with bipolar affective disorder and 113 healthy controls, all of Spanish origin. No significant association was observed between any of the four polymorphisms at the HTR2A locus, whether tested individually or as haplotypes, and bipolar affective disorder. The lack of association suggests that HTR2A is not a major risk factor for bipolar affective disorder.

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Genetic variation of the 5-HT(2A) receptor gene and bipolar affective disorder

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