TY - JOUR
T1 - Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
AU - Okbay, Aysu
AU - Baselmans, Bart M L
AU - De Neve, Jan-Emmanuel
AU - Turley, Patrick
AU - Nivard, Michel G
AU - Fontana, Mark Alan
AU - Meddens, S Fleur W
AU - Linnér, Richard Karlsson
AU - Rietveld, Cornelius A
AU - Derringer, Jaime
AU - Gratten, Jacob
AU - Lee, James J
AU - Liu, Jimmy Z
AU - de Vlaming, Ronald
AU - Ahluwalia, Tarunveer S
AU - Buchwald, Jadwiga
AU - Cavadino, Alana
AU - Frazier-Wood, Alexis C
AU - Furlotte, Nicholas A
AU - Garfield, Victoria
AU - Geisel, Marie Henrike
AU - Gonzalez, Juan R
AU - Haitjema, Saskia
AU - Karlsson, Robert
AU - van der Laan, Sander W
AU - Ladwig, Karl-Heinz
AU - Lahti, Jari
AU - van der Lee, Sven J
AU - Lind, Penelope A
AU - Liu, Tian
AU - Matteson, Lindsay
AU - Mihailov, Evelin
AU - Miller, Michael B
AU - Minica, Camelia C
AU - Nolte, Ilja M
AU - Mook-Kanamori, Dennis
AU - van der Most, Peter J
AU - Oldmeadow, Christopher
AU - Qian, Yong
AU - Raitakari, Olli
AU - Rawal, Rajesh
AU - Realo, Anu
AU - Rueedi, Rico
AU - Schmidt, Börge
AU - Smith, Albert V
AU - Stergiakouli, Evie
AU - Tanaka, Toshiko
AU - Pasterkamp, Gerard
AU - den Ruijter, Hester M
AU - Alizadeh, Behrooz Z
PY - 2016/6
Y1 - 2016/6
N2 - Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (|ρ^| ≈ 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.
AB - Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (|ρ^| ≈ 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.
U2 - 10.1038/ng.3552
DO - 10.1038/ng.3552
M3 - Article
C2 - 27089181
SN - 1061-4036
VL - 48
SP - 624
EP - 633
JO - Nature Genetics
JF - Nature Genetics
IS - 6
ER -