Genetic risk and architecture of amyotrophic lateral sclerosis

W. van Rheenen

Genetic risk and architecture of amyotrophic lateral sclerosis

W. van Rheenen

Research output: Thesis › Doctoral thesis 1 (Research UU / Graduation UU)

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Abstract

The aim of this thesis was to identify new genetic susceptibility factors, describe the
genetic architecture of ALS and explore the utility of gene expression profiles as a
biomarker for ALS. Following the technical advances over time, this thesis includes single
gene studies, genome-wide associations studies (GWAS), transcriptome analyses and
whole genome sequencing studies. Leveraged together, they have led to several
conclusions and perspectives.

Original language	English
Awarding Institution	University Medical Center (UMC) Utrecht
Supervisors/Advisors	Veldink, Jan, Primary supervisor van den Berg, Leonard, Supervisor
Award date	28 Mar 2017
Publisher	Utrecht University
Print ISBNs	978-90-393-6744-5
Publication status	Published - 28 Mar 2017

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title = "Genetic risk and architecture of amyotrophic lateral sclerosis",

abstract = "The aim of this thesis was to identify new genetic susceptibility factors, describe the genetic architecture of ALS and explore the utility of gene expression profiles as a biomarker for ALS. Following the technical advances over time, this thesis includes single gene studies, genome-wide associations studies (GWAS), transcriptome analyses and whole genome sequencing studies. Leveraged together, they have led to several conclusions and perspectives.",

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AB - The aim of this thesis was to identify new genetic susceptibility factors, describe the genetic architecture of ALS and explore the utility of gene expression profiles as a biomarker for ALS. Following the technical advances over time, this thesis includes single gene studies, genome-wide associations studies (GWAS), transcriptome analyses and whole genome sequencing studies. Leveraged together, they have led to several conclusions and perspectives.

M3 - Doctoral thesis 1 (Research UU / Graduation UU)

SN - 978-90-393-6744-5

PB - Utrecht University

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Genetic risk and architecture of amyotrophic lateral sclerosis

Abstract

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