Genetic loci influencing kidney function and chronic kidney disease

John C Chambers; Weihua Zhang; Graham M Lord; Pim van der Harst; Debbie A Lawlor; Joban S Sehmi; Daniel P Gale; Mark N Wass; Kourosh R Ahmadi; Stephan J L Bakker; Jacqui Beckmann; Henk J G Bilo; Murielle Bochud; Morris J Brown; Mark J Caulfield; John M C Connell; H Terence Cook; Ioana Cotlarciuc; George Davey Smith; Ranil de Silva; Guohong Deng; Olivier Devuyst; Lambert D Dikkeschei; Nada Dimkovic; Mark Dockrell; Anna Dominiczak; Shah Ebrahim; Thomas Eggermann; Martin Farrall; Luigi Ferrucci; Jurgen Floege; Nita G Forouhi; Ron T Gansevoort; Xijin Han; Bo Hedblad; Jaap J Homan van der Heide; Bouke G Hepkema; Maria Hernandez-Fuentes; Elina Hypponen; Toby Johnson; Paul E de Jong; Nanne Kleefstra; Vasiliki Lagou; Marta Lapsley; Yun Li; Ruth J F Loos; Jian'an Luan; Karin Luttropp; Céline Maréchal; Olle Melander; Patricia B Munroe; Louise Nordfors; Afshin Parsa; Leena Peltonen; Brenda W Penninx; Esperanza Perucha; Anneli Pouta; Inga Prokopenko; Paul J Roderick; Aimo Ruokonen; Nilesh J Samani; Serena Sanna; Martin Schalling; David Schlessinger; Georg Schlieper; Marc A J Seelen; Alan R Shuldiner; Marketa Sjögren; Johannes H Smit; Harold Snieder; Nicole Soranzo; Timothy D Spector; Peter Stenvinkel; Michael J E Sternberg; Ramasamyiyer Swaminathan; Toshiko Tanaka; Lielith J Ubink-Veltmaat; Manuela Uda; Peter Vollenweider; Chris Wallace; Dawn Waterworth; Klaus Zerres; Gerard Waeber; Nicholas J Wareham; Patrick H Maxwell; Mark I McCarthy; Marjo-Riitta Jarvelin; Vincent Mooser; Goncalo R Abecasis; Liz Lightstone; James Scott; Gerjan Navis; Paul Elliott; Jaspal S Kooner

doi:10.1038/ng.566

Genetic loci influencing kidney function and chronic kidney disease

John C Chambers, Weihua Zhang, Graham M Lord, Pim van der Harst, Debbie A Lawlor, Joban S Sehmi, Daniel P Gale, Mark N Wass, Kourosh R Ahmadi, Stephan J L Bakker, Jacqui Beckmann, Henk J G Bilo, Murielle Bochud, Morris J Brown, Mark J Caulfield, John M C Connell, H Terence Cook, Ioana Cotlarciuc, George Davey Smith, Ranil de SilvaGuohong Deng, Olivier Devuyst, Lambert D Dikkeschei, Nada Dimkovic, Mark Dockrell, Anna Dominiczak, Shah Ebrahim, Thomas Eggermann, Martin Farrall, Luigi Ferrucci, Jurgen Floege, Nita G Forouhi, Ron T Gansevoort, Xijin Han, Bo Hedblad, Jaap J Homan van der Heide, Bouke G Hepkema, Maria Hernandez-Fuentes, Elina Hypponen, Toby Johnson, Paul E de Jong, Nanne Kleefstra, Vasiliki Lagou, Marta Lapsley, Yun Li, Ruth J F Loos, Jian'an Luan, Karin Luttropp, Céline Maréchal, Olle Melander, Patricia B Munroe, Louise Nordfors, Afshin Parsa, Leena Peltonen, Brenda W Penninx, Esperanza Perucha, Anneli Pouta, Inga Prokopenko, Paul J Roderick, Aimo Ruokonen, Nilesh J Samani, Serena Sanna, Martin Schalling, David Schlessinger, Georg Schlieper, Marc A J Seelen, Alan R Shuldiner, Marketa Sjögren, Johannes H Smit, Harold Snieder, Nicole Soranzo, Timothy D Spector, Peter Stenvinkel, Michael J E Sternberg, Ramasamyiyer Swaminathan, Toshiko Tanaka, Lielith J Ubink-Veltmaat, Manuela Uda, Peter Vollenweider, Chris Wallace, Dawn Waterworth, Klaus Zerres, Gerard Waeber, Nicholas J Wareham, Patrick H Maxwell, Mark I McCarthy, Marjo-Riitta Jarvelin, Vincent Mooser, Goncalo R Abecasis, Liz Lightstone, James Scott, Gerjan Navis, Paul Elliott, Jaspal S Kooner

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.

Original language	English
Pages (from-to)	373-5
Number of pages	3
Journal	Nature Genetics
Volume	42
Issue number	5
DOIs	https://doi.org/10.1038/ng.566
Publication status	Published - May 2010
Externally published	Yes

Keywords

Biological Transport
Creatinine/blood
Cystatin C/metabolism
Europe
Gene Expression Regulation
Genetic Markers/genetics
Genetic Predisposition to Disease
Genetic Variation
Genome-Wide Association Study
Genotype
Glomerular Filtration Rate
Humans
Kidney/physiology
Kidney Failure, Chronic/genetics
Models, Genetic

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10.1038/ng.566

Cite this

Chambers, J. C., Zhang, W., Lord, G. M., van der Harst, P., Lawlor, D. A., Sehmi, J. S., Gale, D. P., Wass, M. N., Ahmadi, K. R., Bakker, S. J. L., Beckmann, J., Bilo, H. J. G., Bochud, M., Brown, M. J., Caulfield, M. J., Connell, J. M. C., Cook, H. T., Cotlarciuc, I., Davey Smith, G., ... Kooner, J. S. (2010). Genetic loci influencing kidney function and chronic kidney disease. Nature Genetics, 42(5), 373-5. https://doi.org/10.1038/ng.566

@article{fc71899354b1436e89e136e0d37eed40,

title = "Genetic loci influencing kidney function and chronic kidney disease",

abstract = "Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.",

keywords = "Biological Transport, Creatinine/blood, Cystatin C/metabolism, Europe, Gene Expression Regulation, Genetic Markers/genetics, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Genotype, Glomerular Filtration Rate, Humans, Kidney/physiology, Kidney Failure, Chronic/genetics, Models, Genetic",

author = "Chambers, {John C} and Weihua Zhang and Lord, {Graham M} and {van der Harst}, Pim and Lawlor, {Debbie A} and Sehmi, {Joban S} and Gale, {Daniel P} and Wass, {Mark N} and Ahmadi, {Kourosh R} and Bakker, {Stephan J L} and Jacqui Beckmann and Bilo, {Henk J G} and Murielle Bochud and Brown, {Morris J} and Caulfield, {Mark J} and Connell, {John M C} and Cook, {H Terence} and Ioana Cotlarciuc and {Davey Smith}, George and {de Silva}, Ranil and Guohong Deng and Olivier Devuyst and Dikkeschei, {Lambert D} and Nada Dimkovic and Mark Dockrell and Anna Dominiczak and Shah Ebrahim and Thomas Eggermann and Martin Farrall and Luigi Ferrucci and Jurgen Floege and Forouhi, {Nita G} and Gansevoort, {Ron T} and Xijin Han and Bo Hedblad and {Homan van der Heide}, {Jaap J} and Hepkema, {Bouke G} and Maria Hernandez-Fuentes and Elina Hypponen and Toby Johnson and {de Jong}, {Paul E} and Nanne Kleefstra and Vasiliki Lagou and Marta Lapsley and Yun Li and Loos, {Ruth J F} and Jian'an Luan and Karin Luttropp and C{\'e}line Mar{\'e}chal and Olle Melander and Munroe, {Patricia B} and Louise Nordfors and Afshin Parsa and Leena Peltonen and Penninx, {Brenda W} and Esperanza Perucha and Anneli Pouta and Inga Prokopenko and Roderick, {Paul J} and Aimo Ruokonen and Samani, {Nilesh J} and Serena Sanna and Martin Schalling and David Schlessinger and Georg Schlieper and Seelen, {Marc A J} and Shuldiner, {Alan R} and Marketa Sj{\"o}gren and Smit, {Johannes H} and Harold Snieder and Nicole Soranzo and Spector, {Timothy D} and Peter Stenvinkel and Sternberg, {Michael J E} and Ramasamyiyer Swaminathan and Toshiko Tanaka and Ubink-Veltmaat, {Lielith J} and Manuela Uda and Peter Vollenweider and Chris Wallace and Dawn Waterworth and Klaus Zerres and Gerard Waeber and Wareham, {Nicholas J} and Maxwell, {Patrick H} and McCarthy, {Mark I} and Marjo-Riitta Jarvelin and Vincent Mooser and Abecasis, {Goncalo R} and Liz Lightstone and James Scott and Gerjan Navis and Paul Elliott and Kooner, {Jaspal S}",

year = "2010",

month = may,

doi = "10.1038/ng.566",

language = "English",

volume = "42",

pages = "373--5",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

number = "5",

}

Chambers, JC, Zhang, W, Lord, GM, van der Harst, P, Lawlor, DA, Sehmi, JS, Gale, DP, Wass, MN, Ahmadi, KR, Bakker, SJL, Beckmann, J, Bilo, HJG, Bochud, M, Brown, MJ, Caulfield, MJ, Connell, JMC, Cook, HT, Cotlarciuc, I, Davey Smith, G, de Silva, R, Deng, G, Devuyst, O, Dikkeschei, LD, Dimkovic, N, Dockrell, M, Dominiczak, A, Ebrahim, S, Eggermann, T, Farrall, M, Ferrucci, L, Floege, J, Forouhi, NG, Gansevoort, RT, Han, X, Hedblad, B, Homan van der Heide, JJ, Hepkema, BG, Hernandez-Fuentes, M, Hypponen, E, Johnson, T, de Jong, PE, Kleefstra, N, Lagou, V, Lapsley, M, Li, Y, Loos, RJF, Luan, J, Luttropp, K, Maréchal, C, Melander, O, Munroe, PB, Nordfors, L, Parsa, A, Peltonen, L, Penninx, BW, Perucha, E, Pouta, A, Prokopenko, I, Roderick, PJ, Ruokonen, A, Samani, NJ, Sanna, S, Schalling, M, Schlessinger, D, Schlieper, G, Seelen, MAJ, Shuldiner, AR, Sjögren, M, Smit, JH, Snieder, H, Soranzo, N, Spector, TD, Stenvinkel, P, Sternberg, MJE, Swaminathan, R, Tanaka, T, Ubink-Veltmaat, LJ, Uda, M, Vollenweider, P, Wallace, C, Waterworth, D, Zerres, K, Waeber, G, Wareham, NJ, Maxwell, PH, McCarthy, MI, Jarvelin, M-R, Mooser, V, Abecasis, GR, Lightstone, L, Scott, J, Navis, G, Elliott, P & Kooner, JS 2010, 'Genetic loci influencing kidney function and chronic kidney disease', Nature Genetics, vol. 42, no. 5, pp. 373-5. https://doi.org/10.1038/ng.566

TY - JOUR

T1 - Genetic loci influencing kidney function and chronic kidney disease

AU - Chambers, John C

AU - Zhang, Weihua

AU - Lord, Graham M

AU - van der Harst, Pim

AU - Lawlor, Debbie A

AU - Sehmi, Joban S

AU - Gale, Daniel P

AU - Wass, Mark N

AU - Ahmadi, Kourosh R

AU - Bakker, Stephan J L

AU - Beckmann, Jacqui

AU - Bilo, Henk J G

AU - Bochud, Murielle

AU - Brown, Morris J

AU - Caulfield, Mark J

AU - Connell, John M C

AU - Cook, H Terence

AU - Cotlarciuc, Ioana

AU - Davey Smith, George

AU - de Silva, Ranil

AU - Deng, Guohong

AU - Devuyst, Olivier

AU - Dikkeschei, Lambert D

AU - Dimkovic, Nada

AU - Dockrell, Mark

AU - Dominiczak, Anna

AU - Ebrahim, Shah

AU - Eggermann, Thomas

AU - Farrall, Martin

AU - Ferrucci, Luigi

AU - Floege, Jurgen

AU - Forouhi, Nita G

AU - Gansevoort, Ron T

AU - Han, Xijin

AU - Hedblad, Bo

AU - Homan van der Heide, Jaap J

AU - Hepkema, Bouke G

AU - Hernandez-Fuentes, Maria

AU - Hypponen, Elina

AU - Johnson, Toby

AU - de Jong, Paul E

AU - Kleefstra, Nanne

AU - Lagou, Vasiliki

AU - Lapsley, Marta

AU - Li, Yun

AU - Loos, Ruth J F

AU - Luan, Jian'an

AU - Luttropp, Karin

AU - Maréchal, Céline

AU - Melander, Olle

AU - Munroe, Patricia B

AU - Nordfors, Louise

AU - Parsa, Afshin

AU - Peltonen, Leena

AU - Penninx, Brenda W

AU - Perucha, Esperanza

AU - Pouta, Anneli

AU - Prokopenko, Inga

AU - Roderick, Paul J

AU - Ruokonen, Aimo

AU - Samani, Nilesh J

AU - Sanna, Serena

AU - Schalling, Martin

AU - Schlessinger, David

AU - Schlieper, Georg

AU - Seelen, Marc A J

AU - Shuldiner, Alan R

AU - Sjögren, Marketa

AU - Smit, Johannes H

AU - Snieder, Harold

AU - Soranzo, Nicole

AU - Spector, Timothy D

AU - Stenvinkel, Peter

AU - Sternberg, Michael J E

AU - Swaminathan, Ramasamyiyer

AU - Tanaka, Toshiko

AU - Ubink-Veltmaat, Lielith J

AU - Uda, Manuela

AU - Vollenweider, Peter

AU - Wallace, Chris

AU - Waterworth, Dawn

AU - Zerres, Klaus

AU - Waeber, Gerard

AU - Wareham, Nicholas J

AU - Maxwell, Patrick H

AU - McCarthy, Mark I

AU - Jarvelin, Marjo-Riitta

AU - Mooser, Vincent

AU - Abecasis, Goncalo R

AU - Lightstone, Liz

AU - Scott, James

AU - Navis, Gerjan

AU - Elliott, Paul

AU - Kooner, Jaspal S

PY - 2010/5

Y1 - 2010/5

N2 - Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.

AB - Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.

KW - Biological Transport

KW - Creatinine/blood

KW - Cystatin C/metabolism

KW - Europe

KW - Gene Expression Regulation

KW - Genetic Markers/genetics

KW - Genetic Predisposition to Disease

KW - Genetic Variation

KW - Genome-Wide Association Study

KW - Genotype

KW - Glomerular Filtration Rate

KW - Humans

KW - Kidney/physiology

KW - Kidney Failure, Chronic/genetics

KW - Models, Genetic

U2 - 10.1038/ng.566

DO - 10.1038/ng.566

M3 - Article

C2 - 20383145

SN - 1061-4036

VL - 42

SP - 373

EP - 375

JO - Nature Genetics

JF - Nature Genetics

IS - 5

ER -

Genetic loci influencing kidney function and chronic kidney disease

Abstract

Keywords

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