Genetic influences on 24 h blood pressure profiles in a hypertensive population: role of the angiotensin-converting enzyme insertion/deletion and angiotensin II type 1 receptor A1166C gene polymorphisms

OBJECTIVE: Data on the association of the ACE I/D and AT1R A1166C polymorphisms with hypertension are conflicting. Most studies, however, have focused on office blood pressure (BP) only. The objective of the present study was to investigate the association of BP with the angiotensin-converting enzyme insertion/deletion (ACE I/D) and angiotensin II type 1 receptor A1166C (AT1R A1166C) polymorphisms by means of both office and ambulatory blood pressure monitoring (ABPM). METHODS AND RESULTS: A total of 348 hypertensive patients participated in this study. Office BP did not differ between the various ACE or AT1R genotype groups. However, ambulatory BP and BP load were positively associated with the ACE I/D polymorphism. This was more apparent in men than in women. There were no differences in heart rate, BP variability, and amount of dipping. The AT1R A1166C polymorphism showed no consistent association with blood pressure (load). CONCLUSION: From these data we conclude that frequent measuring of blood pressure by ABPM is crucial to find an association of the ACE D allele with various aspects of blood pressure.