TY - JOUR
T1 - Genetic Heterogeneity of Familial Hemiplegic Migraine
AU - Ophoff, Roel A.
AU - van Eijk, Ronald
AU - Sandkuijl, Lodewijk A.
AU - Terwindt, Gisela M.
AU - Grubben, Caroline P.M.
AU - Haan, Joost
AU - Lindhout, Dick
AU - Ferrari, Michel D.
AU - Frants, Rune R.
PY - 1994/7/1
Y1 - 1994/7/1
N2 - Familial hemiplegic migraine (FHM) is a distinctive form of migraine with an autosomal dominant mode of inheritance. The migraine-like attacks are associated with transient hemiparesis. A locus for FHM has recently been assigned to chromosome 19 by linkage mapping. In the present study, five unrelated pedigrees with multiple members suffering from hemiplegic migraine were investigated. In two of the pedigrees additional symptoms, cerebellar ataxia and benign neonatal convulsions, respectively, were observed in affected members. Three pedigrees showed linkage to loci D19S391, D19S221, and D19S226 at chromosome 19p13. Haplotyping suggested a location of a FHM gene between D19S391 and D19S221. In the two remaining families, evidence against linkage was found. These results confirm the localization of a gene for familial hemiplegic migraine to the short arm of chromosome 19, but locus heterogeneity not corresponding to the observed clinical heterogeneity is likely to exist.
AB - Familial hemiplegic migraine (FHM) is a distinctive form of migraine with an autosomal dominant mode of inheritance. The migraine-like attacks are associated with transient hemiparesis. A locus for FHM has recently been assigned to chromosome 19 by linkage mapping. In the present study, five unrelated pedigrees with multiple members suffering from hemiplegic migraine were investigated. In two of the pedigrees additional symptoms, cerebellar ataxia and benign neonatal convulsions, respectively, were observed in affected members. Three pedigrees showed linkage to loci D19S391, D19S221, and D19S226 at chromosome 19p13. Haplotyping suggested a location of a FHM gene between D19S391 and D19S221. In the two remaining families, evidence against linkage was found. These results confirm the localization of a gene for familial hemiplegic migraine to the short arm of chromosome 19, but locus heterogeneity not corresponding to the observed clinical heterogeneity is likely to exist.
UR - https://www.scopus.com/pages/publications/0028142733
U2 - 10.1006/geno.1994.1340
DO - 10.1006/geno.1994.1340
M3 - Article
C2 - 7959770
AN - SCOPUS:0028142733
SN - 0888-7543
VL - 22
SP - 21
EP - 26
JO - Genomics
JF - Genomics
IS - 1
ER -