Genetic cross-disorder analysis in psychiatry: From methodology to clinical utility

Dick Schijven; Jan H. Veldink; Jurjen J. Luykx

doi:10.1192/bjp.2019.72

Genetic cross-disorder analysis in psychiatry: From methodology to clinical utility

Dick Schijven
, Jan H. Veldink
, Jurjen J. Luykx^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Genome-wide association studies have uncovered hundreds of loci associated with psychiatric disorders. Cross-disorder studies are among the prime ramifications of such research. Here, we discuss the methodology of the most widespread methods and their clinical utility with regard to diagnosis, prediction, disease aetiology and treatment in psychiatry.

Original language	English
Pages (from-to)	246-249
Number of pages	4
Journal	British Journal of Psychiatry
Volume	216
Issue number	5
DOIs	https://doi.org/10.1192/bjp.2019.72
Publication status	Published - 1 May 2020

Keywords

Cross-disorder
Genetic correlation
Genetics
Genome-wide association studies (GWAS)
Pleiotropy

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10.1192/bjp.2019.72

genetic-cross-disorder-analysis-in-psychiatry-from-methodology-to-clinical-utilityFinal published version, 138 KBLicence: Taverne

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title = "Genetic cross-disorder analysis in psychiatry: From methodology to clinical utility",

abstract = "Genome-wide association studies have uncovered hundreds of loci associated with psychiatric disorders. Cross-disorder studies are among the prime ramifications of such research. Here, we discuss the methodology of the most widespread methods and their clinical utility with regard to diagnosis, prediction, disease aetiology and treatment in psychiatry.",

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AB - Genome-wide association studies have uncovered hundreds of loci associated with psychiatric disorders. Cross-disorder studies are among the prime ramifications of such research. Here, we discuss the methodology of the most widespread methods and their clinical utility with regard to diagnosis, prediction, disease aetiology and treatment in psychiatry.

KW - Cross-disorder

KW - Genetic correlation

KW - Genetics

KW - Genome-wide association studies (GWAS)

KW - Pleiotropy

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Genetic cross-disorder analysis in psychiatry: From methodology to clinical utility

Abstract

Keywords

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