TY - JOUR
T1 - Gender Based Analysis of Predictors of All Cause Death After Transcatheter Aortic Valve Implantation
AU - Conrotto, Federico
AU - D'Ascenzo, Fabrizio
AU - Salizzoni, Stefano
AU - Presbitero, Patrizia
AU - Agostoni, Pierfrancesco
AU - Tamburino, Corrado
AU - Tarantini, Giuseppe
AU - Bedogni, Francesco
AU - Nijhoff, Freek
AU - Gasparetto, Valeria
AU - Napodano, Massimo
AU - Ferrante, Giuseppe
AU - Rossi, Marco Luciano
AU - Stella, Pieter
AU - Brambilla, Nedy
AU - Barbanti, Marco
AU - Giordana, Francesca
AU - Grasso, Costanza
AU - Zoccai, Giuseppe Biondi
AU - Moretti, Claudio
AU - D'Amico, Maurizio
AU - Rinaldi, Mauro
AU - Gaita, Fiorenzo
AU - Marra, Sebastiano
AU - Agostoni, Ago
PY - 2014/10/15
Y1 - 2014/10/15
N2 - The impact of gender-related pathophysiologic features of aortic stenosis on transcatheter aortic valve implantation (TAVI) outcomes remains to be determined, as does the consistency of predictors of mortality between the genders. All consecutive patients who underwent TAVI at 6 institutions were enrolled in this study and stratified according to gender. Midterm all-cause mortality was the primary end point, with events at 30 days and at midterm as secondary end points. All events were adjudicated according to Valve Academic Research Consortium definitions. Eight hundred thirty-six patients were enrolled, 464(55.5%) of whom were female. At midterm follow-up (median 365 days, interquartile range 100 to 516) women had similar rates of all-cause mortality compared with men (18.1% vs 22.6%, p = 0.11) and similar incidence of myocardial infarction and cerebrovascular accident. Gender did not affect mortality also on multivariate analysis. Among clinical and procedural features, glomerular filtration rate 50 mm Hg (HR 2.26, 95% CI 1.26 to 4.02) independently predicted mortality in women, while insulin-treated diabetes (HR 3.45,95% CI 1.47 to 8.09), previous stroke (HR 3.42, 95% CI 1.43 to 8.18), and an ejection fraction
AB - The impact of gender-related pathophysiologic features of aortic stenosis on transcatheter aortic valve implantation (TAVI) outcomes remains to be determined, as does the consistency of predictors of mortality between the genders. All consecutive patients who underwent TAVI at 6 institutions were enrolled in this study and stratified according to gender. Midterm all-cause mortality was the primary end point, with events at 30 days and at midterm as secondary end points. All events were adjudicated according to Valve Academic Research Consortium definitions. Eight hundred thirty-six patients were enrolled, 464(55.5%) of whom were female. At midterm follow-up (median 365 days, interquartile range 100 to 516) women had similar rates of all-cause mortality compared with men (18.1% vs 22.6%, p = 0.11) and similar incidence of myocardial infarction and cerebrovascular accident. Gender did not affect mortality also on multivariate analysis. Among clinical and procedural features, glomerular filtration rate 50 mm Hg (HR 2.26, 95% CI 1.26 to 4.02) independently predicted mortality in women, while insulin-treated diabetes (HR 3.45,95% CI 1.47 to 8.09), previous stroke (HR 3.42, 95% CI 1.43 to 8.18), and an ejection fraction
KW - LEFT-VENTRICULAR GEOMETRY
KW - SEX-RELATED DIFFERENCES
KW - CLINICAL PRESENTATION
KW - STENOSIS
KW - REPLACEMENT
KW - OUTCOMES
KW - MULTICENTER
KW - IMPACT
KW - MORTALITY
KW - REGURGITATION
U2 - 10.1016/j.amjcard.2014.07.053
DO - 10.1016/j.amjcard.2014.07.053
M3 - Article
C2 - 25159239
SN - 0002-9149
VL - 114
SP - 1269
EP - 1274
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 8
ER -