TY - JOUR
T1 - Gelatin-Methacryloyl Hydrogels
T2 - Towards Biofabrication-Based Tissue Repair
AU - Klotz, Barbara J
AU - Gawlitta, Debby
AU - Rosenberg, Antoine J W P
AU - Malda, J
AU - Melchels, Ferry P. W.
N1 - Crown Copyright © 2016. Published by Elsevier Ltd. All rights reserved.
PY - 2016/5
Y1 - 2016/5
N2 - Research over the past decade on the cell-biomaterial interface has shifted to the third dimension. Besides mimicking the native extracellular environment by 3D cell culture, hydrogels offer the possibility to generate well-defined 3D biofabricated tissue analogs. In this context, gelatin-methacryloyl (gelMA) hydrogels have recently gained increased attention. This interest is sparked by the combination of the inherent bioactivity of gelatin and the physicochemical tailorability of photo-crosslinkable hydrogels. GelMA is a versatile matrix that can be used to engineer tissue analogs ranging from vasculature to cartilage and bone. Convergence of biological and biofabrication approaches is necessary to progress from merely proving cell functionality or construct shape fidelity towards regenerating tissues. GelMA has a critical pioneering role in this process and could be used to accelerate the development of clinically relevant applications.
AB - Research over the past decade on the cell-biomaterial interface has shifted to the third dimension. Besides mimicking the native extracellular environment by 3D cell culture, hydrogels offer the possibility to generate well-defined 3D biofabricated tissue analogs. In this context, gelatin-methacryloyl (gelMA) hydrogels have recently gained increased attention. This interest is sparked by the combination of the inherent bioactivity of gelatin and the physicochemical tailorability of photo-crosslinkable hydrogels. GelMA is a versatile matrix that can be used to engineer tissue analogs ranging from vasculature to cartilage and bone. Convergence of biological and biofabrication approaches is necessary to progress from merely proving cell functionality or construct shape fidelity towards regenerating tissues. GelMA has a critical pioneering role in this process and could be used to accelerate the development of clinically relevant applications.
U2 - 10.1016/j.tibtech.2016.01.002
DO - 10.1016/j.tibtech.2016.01.002
M3 - Literature review
C2 - 26867787
SN - 0167-7799
VL - 34
SP - 394
EP - 407
JO - Trends in biotechnology
JF - Trends in biotechnology
IS - 5
M1 - 26867787
ER -