TY - JOUR
T1 - Gadoxetic acid disodium-enhanced MR imaging of cholangiolocellular carcinoma of the liver
T2 - imaging characteristics and histopathological correlations
AU - Haradome, Hiroki
AU - Unno, Toshiyuki
AU - Morisaka, Hiroyuki
AU - Toda, Yusuke
AU - Kwee, Thomas C.
AU - Kondo, Hiroshi
AU - Sano, Keiji
AU - Ichikawa, Tomoaki
AU - Kondo, Fukuo
AU - Sugitani, Masahiko
AU - Takayama, Tadatoshi
PY - 2017/11
Y1 - 2017/11
N2 - Objectives: To review the gadoxetic acid disodium (EOB)-enhanced magnetic resonance (MR) imaging features of cholangiolocellular carcinoma (CoCC) of the liver and compare them with those of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). Methods: EOB-enhanced MR images of 19 patients with CoCC, 23 with ICC, and 51 with HCC were retrospectively evaluated qualitatively and quantitatively. Univariate and multivariate analyses were performed to determine the characteristic MR features of CoCC with histopathological–imaging correlation. Results: Multivariate logistic regression analysis showed that dot-/band-shaped internal enhancement during the arterial and portal phases (P <0.001), and larger arterial ring enhancement ratio (CoCC, 0.13 ± 0.04; ICC, 0.074 ± 0.04; P = 0.013) were significantly independently associated with CoCC in contrast to ICC, whereas several MR features including progressive enhancement during the portal and late phases (P <0.001), target appearance in the hepatocyte phase (P = 0.004), and vessel penetration (P = 0.013) were significantly more frequently associated with CoCC than HCC. The dot-/band-like internal enhancement (78.9% of CoCCs) histopathologically corresponded to the tumour cell nest with vascular proliferations and retained Glisson's sheath structure. Conclusions: EOB-enhanced MR features of CoCC largely differ from those of HCC but are similar to those of ICC. However, the finding of thicker arterial ring enhancement with dot-/band-like internal enhancement could help differentiate CoCC from ICC. Key Points: • Gadoxetic acid-enhanced MR features of cholangiolocellular carcinoma (CoCC) resembled those of intrahepatic cholangiocarcinoma (ICC). • Gadoxetic acid-enhanced MR features of CoCC largely differed from those of hepatocellular carcinoma. • Dot-/band-like internal enhancement of CoCC may be helpful for differentiating from ICC. • Arterial ring enhancement of CoCC was larger than that of ICC.
AB - Objectives: To review the gadoxetic acid disodium (EOB)-enhanced magnetic resonance (MR) imaging features of cholangiolocellular carcinoma (CoCC) of the liver and compare them with those of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). Methods: EOB-enhanced MR images of 19 patients with CoCC, 23 with ICC, and 51 with HCC were retrospectively evaluated qualitatively and quantitatively. Univariate and multivariate analyses were performed to determine the characteristic MR features of CoCC with histopathological–imaging correlation. Results: Multivariate logistic regression analysis showed that dot-/band-shaped internal enhancement during the arterial and portal phases (P <0.001), and larger arterial ring enhancement ratio (CoCC, 0.13 ± 0.04; ICC, 0.074 ± 0.04; P = 0.013) were significantly independently associated with CoCC in contrast to ICC, whereas several MR features including progressive enhancement during the portal and late phases (P <0.001), target appearance in the hepatocyte phase (P = 0.004), and vessel penetration (P = 0.013) were significantly more frequently associated with CoCC than HCC. The dot-/band-like internal enhancement (78.9% of CoCCs) histopathologically corresponded to the tumour cell nest with vascular proliferations and retained Glisson's sheath structure. Conclusions: EOB-enhanced MR features of CoCC largely differ from those of HCC but are similar to those of ICC. However, the finding of thicker arterial ring enhancement with dot-/band-like internal enhancement could help differentiate CoCC from ICC. Key Points: • Gadoxetic acid-enhanced MR features of cholangiolocellular carcinoma (CoCC) resembled those of intrahepatic cholangiocarcinoma (ICC). • Gadoxetic acid-enhanced MR features of CoCC largely differed from those of hepatocellular carcinoma. • Dot-/band-like internal enhancement of CoCC may be helpful for differentiating from ICC. • Arterial ring enhancement of CoCC was larger than that of ICC.
KW - Cholangiolocellular carcinoma
KW - Gadoxetic acid disodium-enhanced magnetic resonance imaging
KW - Hepatocellular carcinoma
KW - Intrahepatic cholangiocarcinoma
KW - Liver
UR - https://www.scopus.com/pages/publications/85017895289
U2 - 10.1007/s00330-017-4811-2
DO - 10.1007/s00330-017-4811-2
M3 - Article
C2 - 28439650
AN - SCOPUS:85017895289
SN - 0938-7994
VL - 27
SP - 4461
EP - 4471
JO - European Radiology
JF - European Radiology
IS - 11
ER -