Abstract
Matrix metalloproteinase (MMP) activation is an: essential feature of pathological and physiological arterial enlargement or shrinkage. Recently, furin-activated membrane type-1 MMP (MT1-MMP) was identified as the in vivo activator of MMP2 in mice. Although arterial enlargement and shrinkage are important in several pathological processes, this proprotein convertase-MT1-MMP axis has not been described during arterial remodeling. In rabbit femoral and carotid arteries, we report an increase in furin and MT1-MMP mRNA levels before and at the onset of arterial remodeling followed by an increase in activated MMP2. This reveals the presence of the proprotein convertase-MT1-MMP axis in flow-induced arterial remodeling and identifies furin as a possible target for local intervention in pathological arterial remodeling. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
| Original language | English |
|---|---|
| Pages (from-to) | 37-41 |
| Number of pages | 5 |
| Journal | FEBS letters |
| Volume | 501 |
| Issue number | 1 |
| Publication status | Published - 13 Jul 2001 |
Keywords
- Econometric and Statistical Methods: General
- Geneeskunde (GENK)
- Geneeskunde(GENK)
- Bescherming en bevordering van de menselijke gezondheid
- Other medical specialities