Functionality of the chromosomal passenger complex in cancer

Sanne Hindriksen; Amanda Meppelink; Susanne M A Lens

doi:10.1042/BST20140275

Functionality of the chromosomal passenger complex in cancer

Sanne Hindriksen, Amanda Meppelink, Susanne M A Lens

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The evolutionary conserved chromosomal passenger complex (CPC) is essential for faithful transmission of the genome during cell division. Perturbation of this complex in cultured cells gives rise to chromosome segregation errors and cytokinesis failure and as a consequence the ploidy status of the next generation of cells is changed. Aneuploidy and chromosomal instability (CIN) is observed in many human cancers, but whether this may be caused by deregulation of the CPC is unknown. In the present review, we discuss if and how a dysfunctional CPC could contribute to CIN in cancer.

Original language	English
Pages (from-to)	23-32
Number of pages	10
Journal	Biochemical Society Transactions
Volume	43
Issue number	1
DOIs	https://doi.org/10.1042/BST20140275
Publication status	Published - Feb 2015

Keywords

Animals
Aurora Kinase B
Cell Cycle Proteins
Chromosomal Instability
Chromosomal Proteins, Non-Histone
Chromosome Segregation
Cytokinesis
Humans
Inhibitor of Apoptosis Proteins
Multiprotein Complexes
Neoplasms

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10.1042/BST20140275

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title = "Functionality of the chromosomal passenger complex in cancer",

abstract = "The evolutionary conserved chromosomal passenger complex (CPC) is essential for faithful transmission of the genome during cell division. Perturbation of this complex in cultured cells gives rise to chromosome segregation errors and cytokinesis failure and as a consequence the ploidy status of the next generation of cells is changed. Aneuploidy and chromosomal instability (CIN) is observed in many human cancers, but whether this may be caused by deregulation of the CPC is unknown. In the present review, we discuss if and how a dysfunctional CPC could contribute to CIN in cancer.",

keywords = "Animals, Aurora Kinase B, Cell Cycle Proteins, Chromosomal Instability, Chromosomal Proteins, Non-Histone, Chromosome Segregation, Cytokinesis, Humans, Inhibitor of Apoptosis Proteins, Multiprotein Complexes, Neoplasms",

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AU - Hindriksen, Sanne

AU - Meppelink, Amanda

AU - Lens, Susanne M A

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N2 - The evolutionary conserved chromosomal passenger complex (CPC) is essential for faithful transmission of the genome during cell division. Perturbation of this complex in cultured cells gives rise to chromosome segregation errors and cytokinesis failure and as a consequence the ploidy status of the next generation of cells is changed. Aneuploidy and chromosomal instability (CIN) is observed in many human cancers, but whether this may be caused by deregulation of the CPC is unknown. In the present review, we discuss if and how a dysfunctional CPC could contribute to CIN in cancer.

AB - The evolutionary conserved chromosomal passenger complex (CPC) is essential for faithful transmission of the genome during cell division. Perturbation of this complex in cultured cells gives rise to chromosome segregation errors and cytokinesis failure and as a consequence the ploidy status of the next generation of cells is changed. Aneuploidy and chromosomal instability (CIN) is observed in many human cancers, but whether this may be caused by deregulation of the CPC is unknown. In the present review, we discuss if and how a dysfunctional CPC could contribute to CIN in cancer.

KW - Animals

KW - Aurora Kinase B

KW - Cell Cycle Proteins

KW - Chromosomal Instability

KW - Chromosomal Proteins, Non-Histone

KW - Chromosome Segregation

KW - Cytokinesis

KW - Humans

KW - Inhibitor of Apoptosis Proteins

KW - Multiprotein Complexes

KW - Neoplasms

U2 - 10.1042/BST20140275

DO - 10.1042/BST20140275

M3 - Article

C2 - 25619243

SN - 0300-5127

VL - 43

SP - 23

EP - 32

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

IS - 1

ER -

Functionality of the chromosomal passenger complex in cancer

Abstract

Keywords

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