TY - JOUR
T1 - Functional and genetic predisposition to rhinovirus lower respiratory tract infections in prematurely born infants
AU - Drysdale, Simon B.
AU - Alcazar, Mireia
AU - Wilson, Theresa
AU - Smith, Melvyn
AU - Zuckerman, Mark
AU - Hodemaekers, Hennie M.
AU - Janssen, Riny
AU - Bont, Louis
AU - Johnston, Sebastian L.
AU - Greenough, Anne
PY - 2016/12
Y1 - 2016/12
N2 - Term born infants are predisposed to human rhinovirus (HRV) lower respiratory tract infections (LRTI) by reduced neonatal lung function and genetic susceptibility. Our aim was to investigate whether prematurely born infants were similarly predisposed to HRV LRTIs or any other viral LRTIs. Infants born less than 36 weeks of gestational age were recruited. Prior to neonatal/maternity unit discharge, lung function (functional residual capacity by helium gas dilution and multiple breath washout, lung clearance index and compliance (Crs), and resistance (Rrs) of the respiratory system) was assessed and DNA samples assessed for eight single nucleotide polymorphisms (SNPs) in seven genes: ADAM33, IL10, MMP16 NFκB1A,SFTPC, VDR, and NOS2A. Infants were prospectively followed until 1 year corrected age. Nasopharyngeal aspirates (NPAs) were sent whenever an infant developed a LRTI and tested for 13 viruses. One hundred and thirty-nine infants were included in the analysis. Infants who developed HRV LRTIs had reduced Crs (1.6 versus 1.2 mL/cmH2O/kg, p = 0.044) at 36 weeks postmenstrual age. A SNP in the gene coding for the vitamin D receptor was associated with the development of HRV LRTIs and any viral LRTIs (p = 0.02). Conclusion: Prematurely born infants may have both a functional and genetic predisposition to HRV LRTIs.(Table presented.)
AB - Term born infants are predisposed to human rhinovirus (HRV) lower respiratory tract infections (LRTI) by reduced neonatal lung function and genetic susceptibility. Our aim was to investigate whether prematurely born infants were similarly predisposed to HRV LRTIs or any other viral LRTIs. Infants born less than 36 weeks of gestational age were recruited. Prior to neonatal/maternity unit discharge, lung function (functional residual capacity by helium gas dilution and multiple breath washout, lung clearance index and compliance (Crs), and resistance (Rrs) of the respiratory system) was assessed and DNA samples assessed for eight single nucleotide polymorphisms (SNPs) in seven genes: ADAM33, IL10, MMP16 NFκB1A,SFTPC, VDR, and NOS2A. Infants were prospectively followed until 1 year corrected age. Nasopharyngeal aspirates (NPAs) were sent whenever an infant developed a LRTI and tested for 13 viruses. One hundred and thirty-nine infants were included in the analysis. Infants who developed HRV LRTIs had reduced Crs (1.6 versus 1.2 mL/cmH2O/kg, p = 0.044) at 36 weeks postmenstrual age. A SNP in the gene coding for the vitamin D receptor was associated with the development of HRV LRTIs and any viral LRTIs (p = 0.02). Conclusion: Prematurely born infants may have both a functional and genetic predisposition to HRV LRTIs.(Table presented.)
KW - Compliance and resistance of the respiratory system
KW - Functional residual capacity
KW - Human rhinovirus
KW - Single nucleotide polymorphisms
UR - http://www.scopus.com/inward/record.url?scp=84989181288&partnerID=8YFLogxK
U2 - 10.1007/s00431-016-2780-0
DO - 10.1007/s00431-016-2780-0
M3 - Article
C2 - 27695990
AN - SCOPUS:84989181288
SN - 0340-6199
VL - 175
SP - 1943
EP - 1949
JO - European Journal of Pediatrics
JF - European Journal of Pediatrics
IS - 12
ER -