TY - JOUR
T1 - Fully implanted brain-computer interface in a locked-in patient with ALS
AU - Vansteensel, Mariska J.
AU - Pels, Elmar G M
AU - Bleichner, Martin G.
AU - Branco, Mariana P.
AU - Denison, Timothy
AU - Freudenburg, Zachary V.
AU - Gosselaar, Peter
AU - Leinders, Sacha
AU - Ottens, Thomas H.
AU - Van Den Boom, Max A.
AU - Van Rijen, Peter C.
AU - Aarnoutse, Erik J.
AU - Ramsey, Nick F.
PY - 2016/11/24
Y1 - 2016/11/24
N2 - Options for people with severe paralysis who have lost the ability to communicate orally are limited. We describe a method for communication in a patient with late-stage amyotrophic lateral sclerosis (ALS), involving a fully implanted brain-computer interface that consists of subdural electrodes placed over the motor cortex and a transmitter placed subcutaneously in the left side of the thorax. By attempting to move the hand on the side opposite the implanted electrodes, the patient accurately and independently controlled a computer typing program 28 weeks after electrode placement, at the equivalent of two letters per minute. The brain-computer interface offered autonomous communication that supplemented and at times supplanted the patient's eye-tracking device.
AB - Options for people with severe paralysis who have lost the ability to communicate orally are limited. We describe a method for communication in a patient with late-stage amyotrophic lateral sclerosis (ALS), involving a fully implanted brain-computer interface that consists of subdural electrodes placed over the motor cortex and a transmitter placed subcutaneously in the left side of the thorax. By attempting to move the hand on the side opposite the implanted electrodes, the patient accurately and independently controlled a computer typing program 28 weeks after electrode placement, at the equivalent of two letters per minute. The brain-computer interface offered autonomous communication that supplemented and at times supplanted the patient's eye-tracking device.
UR - https://www.scopus.com/pages/publications/84996964959
U2 - 10.1056/NEJMoa1608085
DO - 10.1056/NEJMoa1608085
M3 - Article
C2 - 27959736
AN - SCOPUS:84996964959
SN - 0028-4793
VL - 375
SP - 2060
EP - 2066
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 21
ER -