From Hazard to Risk - Assessing the Risk

Charlotte Bernhard Madsen*, Geert Houben, Sue Hattersley, René W R Crevel, Ben C. Remington, Joseph L. Baumert

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

2 Citations (Scopus)


Regulatory thresholds for allergenic foods have not yet been developed. This means that public and industrial risk managers do not have regulatory thresholds to decide if a content or level of contamination is acceptable or not. For a long time, data have been inadequate to define safe thresholds for food allergens. More and more challenge data from food allergic patients are now available, and this opens the possibility to perform more advanced food allergy safety and risk assessments. These can be used to inform risk management decisions and ultimately to form the basis for regulatory thresholds. In the chapter we describe three different approaches for safety/risk assessment based on no/low observed adverse effect level, benchmark dose, or probabilistic modeling. These methods are illustrated by examples from real life and the possibilities and limitations are discussed.

Original languageEnglish
Title of host publicationRisk Management for Food Allergy
Number of pages26
ISBN (Print)9780123819888
Publication statusPublished - 1 Nov 2013


  • Food allergy
  • Margin of exposure
  • Probabilistic modeling
  • Risk assessment
  • Safety assessment
  • Uncertainty factors


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