From Genome-Wide Association Studies to Cardiac Electrophysiology: Through the Maze of Biological Complexity

Koen T. Scholman; Veronique M.F. Meijborg; Carolina Gálvez-Montón; Elisabeth M. Lodder; Bastiaan J. Boukens

doi:10.3389/fphys.2020.00557

From Genome-Wide Association Studies to Cardiac Electrophysiology: Through the Maze of Biological Complexity

Koen T. Scholman, Veronique M.F. Meijborg, Carolina Gálvez-Montón, Elisabeth M. Lodder, Bastiaan J. Boukens^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Genome Wide Association Studies (GWAS) have provided an enormous amount of data on genomic loci associated with cardiac electrophysiology and arrhythmias. Clinical relevance, however, remains unclear since GWAS do not provide a mechanistic explanation for this association. Determining the electrophysiological relevance of variants for arrhythmias would aid development of risk stratification models for patients with arrhythmias. In this review, we give an overview of genetic variants related to ECG intervals and arrhythmogenic pathologies and discuss how these variants may influence cardiac electrophysiology and the occurrence of arrhythmias.

Original language	English
Article number	557
Journal	Frontiers in Physiology
Volume	11
DOIs	https://doi.org/10.3389/fphys.2020.00557
Publication status	Published - 27 May 2020
Externally published	Yes

Keywords

arrhythmias
cardiac electrophysiology
gene expression
genetics
GWAS

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10.3389/fphys.2020.00557

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title = "From Genome-Wide Association Studies to Cardiac Electrophysiology: Through the Maze of Biological Complexity",

abstract = "Genome Wide Association Studies (GWAS) have provided an enormous amount of data on genomic loci associated with cardiac electrophysiology and arrhythmias. Clinical relevance, however, remains unclear since GWAS do not provide a mechanistic explanation for this association. Determining the electrophysiological relevance of variants for arrhythmias would aid development of risk stratification models for patients with arrhythmias. In this review, we give an overview of genetic variants related to ECG intervals and arrhythmogenic pathologies and discuss how these variants may influence cardiac electrophysiology and the occurrence of arrhythmias.",

keywords = "arrhythmias, cardiac electrophysiology, gene expression, genetics, GWAS",

author = "Scholman, {Koen T.} and Meijborg, {Veronique M.F.} and Carolina G{\'a}lvez-Mont{\'o}n and Lodder, {Elisabeth M.} and Boukens, {Bastiaan J.}",

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month = may,

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doi = "10.3389/fphys.2020.00557",

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T2 - Through the Maze of Biological Complexity

AU - Scholman, Koen T.

AU - Meijborg, Veronique M.F.

AU - Gálvez-Montón, Carolina

AU - Lodder, Elisabeth M.

AU - Boukens, Bastiaan J.

PY - 2020/5/27

Y1 - 2020/5/27

N2 - Genome Wide Association Studies (GWAS) have provided an enormous amount of data on genomic loci associated with cardiac electrophysiology and arrhythmias. Clinical relevance, however, remains unclear since GWAS do not provide a mechanistic explanation for this association. Determining the electrophysiological relevance of variants for arrhythmias would aid development of risk stratification models for patients with arrhythmias. In this review, we give an overview of genetic variants related to ECG intervals and arrhythmogenic pathologies and discuss how these variants may influence cardiac electrophysiology and the occurrence of arrhythmias.

AB - Genome Wide Association Studies (GWAS) have provided an enormous amount of data on genomic loci associated with cardiac electrophysiology and arrhythmias. Clinical relevance, however, remains unclear since GWAS do not provide a mechanistic explanation for this association. Determining the electrophysiological relevance of variants for arrhythmias would aid development of risk stratification models for patients with arrhythmias. In this review, we give an overview of genetic variants related to ECG intervals and arrhythmogenic pathologies and discuss how these variants may influence cardiac electrophysiology and the occurrence of arrhythmias.

KW - arrhythmias

KW - cardiac electrophysiology

KW - gene expression

KW - genetics

KW - GWAS

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U2 - 10.3389/fphys.2020.00557

DO - 10.3389/fphys.2020.00557

M3 - Review article

AN - SCOPUS:85086154339

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VL - 11

JO - Frontiers in Physiology

JF - Frontiers in Physiology

M1 - 557

ER -

From Genome-Wide Association Studies to Cardiac Electrophysiology: Through the Maze of Biological Complexity

Abstract

Keywords

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