TY - JOUR
T1 - From Epigenetic Associations to Biological and Psychosocial Explanations in Mental Health
AU - Renzi, Chiara
AU - Provencal, Nadine
AU - Bassil, Katherine C
AU - Evers, Kathinka
AU - Kihlbom, Ulrik
AU - Radford, Elizabeth J
AU - Koupil, Ilona
AU - Mueller-Myhsok, Bertram
AU - Hansson, Mats G
AU - Rutten, Bart P F
N1 - Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - The development of mental disorders constitutes a complex phenomenon driven by unique social, psychological and biological factors such as genetics and epigenetics, throughout an individual's life course. Both environmental and genetic factors have an impact on mental health phenotypes and act simultaneously to induce changes in brain and behavior. Here, we describe and critically evaluate the current literature on gene-environment interactions and epigenetics on mental health by highlighting recent human and animal studies. We furthermore review some of the main ethical and social implications concerning gene-environment interactions and epigenetics and provide explanations and suggestions on how to move from statistical and epigenetic associations to biological and psychological explanations within a multi-disciplinary and integrative approach of understanding mental health.
AB - The development of mental disorders constitutes a complex phenomenon driven by unique social, psychological and biological factors such as genetics and epigenetics, throughout an individual's life course. Both environmental and genetic factors have an impact on mental health phenotypes and act simultaneously to induce changes in brain and behavior. Here, we describe and critically evaluate the current literature on gene-environment interactions and epigenetics on mental health by highlighting recent human and animal studies. We furthermore review some of the main ethical and social implications concerning gene-environment interactions and epigenetics and provide explanations and suggestions on how to move from statistical and epigenetic associations to biological and psychological explanations within a multi-disciplinary and integrative approach of understanding mental health.
KW - Animals
KW - Environmental Exposure
KW - Epigenesis, Genetic
KW - Gene-Environment Interaction
KW - Humans
KW - Interdisciplinary Research
KW - Mental Disorders/genetics
KW - Mental Health
UR - http://www.scopus.com/inward/record.url?scp=85048190625&partnerID=8YFLogxK
U2 - 10.1016/bs.pmbts.2018.04.011
DO - 10.1016/bs.pmbts.2018.04.011
M3 - Review article
C2 - 30072059
SN - 1877-1173
VL - 158
SP - 299
EP - 323
JO - Progress in molecular biology and translational science
JF - Progress in molecular biology and translational science
ER -