Fractures of thoracic vertebrae in patients with locally advanced non-small cell lung carcinoma treated with intensity modulated radiotherapy

Wilma Uyterlinde; Chun Chen; Jose Belderbos; Jan-Jakob Sonke; Charlotte Lange; Josien de Bois; Michel van den Heuvel

doi:10.1016/j.radonc.2015.11.011

Fractures of thoracic vertebrae in patients with locally advanced non-small cell lung carcinoma treated with intensity modulated radiotherapy

Wilma Uyterlinde
, Chun Chen
, Jose Belderbos
, Jan-Jakob Sonke
, Charlotte Lange
, Josien de Bois
, Michel van den Heuvel

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

PURPOSE: To report on the incidence of vertebral fractures in patients treated with Intensity Modulated Radiotherapy (IMRT) for locally advanced non-small cell lung carcinoma (NSCLC) and to analyse the association with clinical and dosimetric parameters.

PATIENTS AND METHODS: Between 2007 and 2012, 524 patients treated with ⩾51 Gy were retrospectively analysed for the incidence of vertebral fractures (VF). Clinical parameters were assessed. In addition, a case control study in 50 patients was performed to study the association between the radiotherapy dose and fractured vertebrae.

RESULTS: Three hundred and thirty-six patients were eligible for analyses. Twenty-eight patients (8%) were observed with VF at a median follow up of 12 months. Age was significantly higher in the group with VF (p<0.01). After balancing age, the mean vertebrae dose was most significantly associated with fractures of the vertebrae (p<0.01).

CONCLUSION: VF was observed in 8% of the patients with locally advanced NSCLC. RT dose was associated with the occurrence of thoracic vertebral fractures.

Original language	English
Pages (from-to)	437-41
Number of pages	5
Journal	Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Volume	118
Issue number	3
DOIs	https://doi.org/10.1016/j.radonc.2015.11.011
Publication status	Published - Mar 2016
Externally published	Yes

Keywords

Adult
Aged
Aged, 80 and over
Carcinoma, Non-Small-Cell Lung/pathology
Case-Control Studies
Female
Fractures, Spontaneous/etiology
Humans
Lung Neoplasms/pathology
Male
Middle Aged
Radiotherapy, Intensity-Modulated/adverse effects
Retrospective Studies
Small Cell Lung Carcinoma/radiotherapy
Spinal Fractures/etiology
Thoracic Vertebrae/injuries

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10.1016/j.radonc.2015.11.011

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Uyterlinde, W., Chen, C., Belderbos, J., Sonke, J.-J., Lange, C., de Bois, J., & van den Heuvel, M. (2016). Fractures of thoracic vertebrae in patients with locally advanced non-small cell lung carcinoma treated with intensity modulated radiotherapy. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 118(3), 437-41. https://doi.org/10.1016/j.radonc.2015.11.011

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title = "Fractures of thoracic vertebrae in patients with locally advanced non-small cell lung carcinoma treated with intensity modulated radiotherapy",

abstract = "PURPOSE: To report on the incidence of vertebral fractures in patients treated with Intensity Modulated Radiotherapy (IMRT) for locally advanced non-small cell lung carcinoma (NSCLC) and to analyse the association with clinical and dosimetric parameters.PATIENTS AND METHODS: Between 2007 and 2012, 524 patients treated with ⩾51 Gy were retrospectively analysed for the incidence of vertebral fractures (VF). Clinical parameters were assessed. In addition, a case control study in 50 patients was performed to study the association between the radiotherapy dose and fractured vertebrae.RESULTS: Three hundred and thirty-six patients were eligible for analyses. Twenty-eight patients (8\%) were observed with VF at a median follow up of 12 months. Age was significantly higher in the group with VF (p<0.01). After balancing age, the mean vertebrae dose was most significantly associated with fractures of the vertebrae (p<0.01).CONCLUSION: VF was observed in 8\% of the patients with locally advanced NSCLC. RT dose was associated with the occurrence of thoracic vertebral fractures.",

keywords = "Adult, Aged, Aged, 80 and over, Carcinoma, Non-Small-Cell Lung/pathology, Case-Control Studies, Female, Fractures, Spontaneous/etiology, Humans, Lung Neoplasms/pathology, Male, Middle Aged, Radiotherapy, Intensity-Modulated/adverse effects, Retrospective Studies, Small Cell Lung Carcinoma/radiotherapy, Spinal Fractures/etiology, Thoracic Vertebrae/injuries",

author = "Wilma Uyterlinde and Chun Chen and Jose Belderbos and Jan-Jakob Sonke and Charlotte Lange and \{de Bois\}, Josien and \{van den Heuvel\}, Michel",

year = "2016",

month = mar,

doi = "10.1016/j.radonc.2015.11.011",

language = "English",

volume = "118",

pages = "437--41",

journal = "Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology",

issn = "0167-8140",

publisher = "Elsevier Ireland Ltd",

number = "3",

}

Uyterlinde, W, Chen, C, Belderbos, J, Sonke, J-J, Lange, C, de Bois, J & van den Heuvel, M 2016, 'Fractures of thoracic vertebrae in patients with locally advanced non-small cell lung carcinoma treated with intensity modulated radiotherapy', Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, vol. 118, no. 3, pp. 437-41. https://doi.org/10.1016/j.radonc.2015.11.011

Fractures of thoracic vertebrae in patients with locally advanced non-small cell lung carcinoma treated with intensity modulated radiotherapy. / Uyterlinde, Wilma; Chen, Chun; Belderbos, Jose et al.
In: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, Vol. 118, No. 3, 03.2016, p. 437-41.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Fractures of thoracic vertebrae in patients with locally advanced non-small cell lung carcinoma treated with intensity modulated radiotherapy

AU - Uyterlinde, Wilma

AU - Chen, Chun

AU - Belderbos, Jose

AU - Sonke, Jan-Jakob

AU - Lange, Charlotte

AU - de Bois, Josien

AU - van den Heuvel, Michel

PY - 2016/3

Y1 - 2016/3

N2 - PURPOSE: To report on the incidence of vertebral fractures in patients treated with Intensity Modulated Radiotherapy (IMRT) for locally advanced non-small cell lung carcinoma (NSCLC) and to analyse the association with clinical and dosimetric parameters.PATIENTS AND METHODS: Between 2007 and 2012, 524 patients treated with ⩾51 Gy were retrospectively analysed for the incidence of vertebral fractures (VF). Clinical parameters were assessed. In addition, a case control study in 50 patients was performed to study the association between the radiotherapy dose and fractured vertebrae.RESULTS: Three hundred and thirty-six patients were eligible for analyses. Twenty-eight patients (8%) were observed with VF at a median follow up of 12 months. Age was significantly higher in the group with VF (p<0.01). After balancing age, the mean vertebrae dose was most significantly associated with fractures of the vertebrae (p<0.01).CONCLUSION: VF was observed in 8% of the patients with locally advanced NSCLC. RT dose was associated with the occurrence of thoracic vertebral fractures.

AB - PURPOSE: To report on the incidence of vertebral fractures in patients treated with Intensity Modulated Radiotherapy (IMRT) for locally advanced non-small cell lung carcinoma (NSCLC) and to analyse the association with clinical and dosimetric parameters.PATIENTS AND METHODS: Between 2007 and 2012, 524 patients treated with ⩾51 Gy were retrospectively analysed for the incidence of vertebral fractures (VF). Clinical parameters were assessed. In addition, a case control study in 50 patients was performed to study the association between the radiotherapy dose and fractured vertebrae.RESULTS: Three hundred and thirty-six patients were eligible for analyses. Twenty-eight patients (8%) were observed with VF at a median follow up of 12 months. Age was significantly higher in the group with VF (p<0.01). After balancing age, the mean vertebrae dose was most significantly associated with fractures of the vertebrae (p<0.01).CONCLUSION: VF was observed in 8% of the patients with locally advanced NSCLC. RT dose was associated with the occurrence of thoracic vertebral fractures.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Carcinoma, Non-Small-Cell Lung/pathology

KW - Case-Control Studies

KW - Female

KW - Fractures, Spontaneous/etiology

KW - Humans

KW - Lung Neoplasms/pathology

KW - Male

KW - Middle Aged

KW - Radiotherapy, Intensity-Modulated/adverse effects

KW - Retrospective Studies

KW - Small Cell Lung Carcinoma/radiotherapy

KW - Spinal Fractures/etiology

KW - Thoracic Vertebrae/injuries

U2 - 10.1016/j.radonc.2015.11.011

DO - 10.1016/j.radonc.2015.11.011

M3 - Article

C2 - 26787423

SN - 0167-8140

VL - 118

SP - 437

EP - 441

JO - Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

JF - Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

IS - 3

ER -

Uyterlinde W, Chen C, Belderbos J, Sonke JJ, Lange C, de Bois J et al. Fractures of thoracic vertebrae in patients with locally advanced non-small cell lung carcinoma treated with intensity modulated radiotherapy. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 2016 Mar;118(3):437-41. doi: 10.1016/j.radonc.2015.11.011

Fractures of thoracic vertebrae in patients with locally advanced non-small cell lung carcinoma treated with intensity modulated radiotherapy

Abstract

Keywords

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