Foveal cone-photoreceptor integrity in aging macula disorder

Martijn J. Kanis; R. P L Wisse; T. T J M Berendschot; Jan Van De Kraats; Dirk Van Norren

doi:10.1167/iovs.07-1181

Foveal cone-photoreceptor integrity in aging macula disorder

Martijn J. Kanis^*, R. P L Wisse, T. T J M Berendschot, Jan Van De Kraats, Dirk Van Norren

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

12 Citations (Scopus)

Abstract

PURPOSE. To establish the relation between AMD stage and a quantitative measure for the integrity of foveal cone photoreceptors related to the optical Stiles-Crawford effect.

METHODS. Fifty-six AMD eyes and 57 control eyes were included in the final analysis. AMD was graded in accordance with the International Classification System into five mutually exclusive stages. Stages 0 to 1 were labeled no AMD, stages 2 to 3 were labeled early AMD, and stage 4 was labeled late AMD. Fundus reflectometry, together with a model-fit procedure, provided information on directional cone reflectance (Rd), a quantitative measure for the integrity of foveal cone photoreceptors. Optical densities of macular pigment (MPOD) and melanin (MOD) were also obtained. A general linear model analysis was used to compare Rd, MPOD, and MOD among the AMD stages.

RESULTS. Mean Rd was lower in early AMD (0.92%, P <0.001) and late AMD (0.86%, P <0.001) compared with mean Rd in the no-AMD stage (1.76%). Mean MPOD was not different in early AMD (0.53, P = 0.05), but it was lower in late AMD (0.19, P <0.001) compared with mean MPOD in the no-AMD stage (0.42). Mean MOD was lower in early (1.09, P = 0.001) and late (1.01, P = 0.004) AMD compared with mean MOD in the no-AMD stage (1.23).

CONCLUSIONS. Foveal cones show signs of misalignment and/or outer segment deterioration in early AMD. Melanin rather than macular pigment may play a protective role against AMD, although loss of these ocular pigments can also be caused by AMD.

Original language	English
Pages (from-to)	2077-2081
Number of pages	5
Journal	Investigative ophthalmology & visual science
Volume	49
Issue number	5
DOIs	https://doi.org/10.1167/iovs.07-1181
Publication status	Published - 2008

Keywords

AGE-RELATED MACULOPATHY
OPTICAL-DENSITY
10-YEAR INCIDENCE
RISK-FACTORS
DEGENERATION
PIGMENT
POPULATION
DISEASE
EYE
REFLECTANCE

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10.1167/iovs.07-1181

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@article{3dd711f4f5b84a9cb7dcf3817dedf130,

title = "Foveal cone-photoreceptor integrity in aging macula disorder",

abstract = "PURPOSE. To establish the relation between AMD stage and a quantitative measure for the integrity of foveal cone photoreceptors related to the optical Stiles-Crawford effect.METHODS. Fifty-six AMD eyes and 57 control eyes were included in the final analysis. AMD was graded in accordance with the International Classification System into five mutually exclusive stages. Stages 0 to 1 were labeled no AMD, stages 2 to 3 were labeled early AMD, and stage 4 was labeled late AMD. Fundus reflectometry, together with a model-fit procedure, provided information on directional cone reflectance (Rd), a quantitative measure for the integrity of foveal cone photoreceptors. Optical densities of macular pigment (MPOD) and melanin (MOD) were also obtained. A general linear model analysis was used to compare Rd, MPOD, and MOD among the AMD stages.RESULTS. Mean Rd was lower in early AMD (0.92%, P <0.001) and late AMD (0.86%, P <0.001) compared with mean Rd in the no-AMD stage (1.76%). Mean MPOD was not different in early AMD (0.53, P = 0.05), but it was lower in late AMD (0.19, P <0.001) compared with mean MPOD in the no-AMD stage (0.42). Mean MOD was lower in early (1.09, P = 0.001) and late (1.01, P = 0.004) AMD compared with mean MOD in the no-AMD stage (1.23).CONCLUSIONS. Foveal cones show signs of misalignment and/or outer segment deterioration in early AMD. Melanin rather than macular pigment may play a protective role against AMD, although loss of these ocular pigments can also be caused by AMD.",

keywords = "AGE-RELATED MACULOPATHY, OPTICAL-DENSITY, 10-YEAR INCIDENCE, RISK-FACTORS, DEGENERATION, PIGMENT, POPULATION, DISEASE, EYE, REFLECTANCE",

author = "Kanis, {Martijn J.} and Wisse, {R. P L} and Berendschot, {T. T J M} and {Van De Kraats}, Jan and {Van Norren}, Dirk",

year = "2008",

doi = "10.1167/iovs.07-1181",

language = "English",

volume = "49",

pages = "2077--2081",

journal = "Investigative ophthalmology & visual science",

issn = "0146-0404",

publisher = "Association for Research in Vision and Ophthalmology Inc.",

number = "5",

}

TY - JOUR

T1 - Foveal cone-photoreceptor integrity in aging macula disorder

AU - Kanis, Martijn J.

AU - Wisse, R. P L

AU - Berendschot, T. T J M

AU - Van De Kraats, Jan

AU - Van Norren, Dirk

PY - 2008

Y1 - 2008

N2 - PURPOSE. To establish the relation between AMD stage and a quantitative measure for the integrity of foveal cone photoreceptors related to the optical Stiles-Crawford effect.METHODS. Fifty-six AMD eyes and 57 control eyes were included in the final analysis. AMD was graded in accordance with the International Classification System into five mutually exclusive stages. Stages 0 to 1 were labeled no AMD, stages 2 to 3 were labeled early AMD, and stage 4 was labeled late AMD. Fundus reflectometry, together with a model-fit procedure, provided information on directional cone reflectance (Rd), a quantitative measure for the integrity of foveal cone photoreceptors. Optical densities of macular pigment (MPOD) and melanin (MOD) were also obtained. A general linear model analysis was used to compare Rd, MPOD, and MOD among the AMD stages.RESULTS. Mean Rd was lower in early AMD (0.92%, P <0.001) and late AMD (0.86%, P <0.001) compared with mean Rd in the no-AMD stage (1.76%). Mean MPOD was not different in early AMD (0.53, P = 0.05), but it was lower in late AMD (0.19, P <0.001) compared with mean MPOD in the no-AMD stage (0.42). Mean MOD was lower in early (1.09, P = 0.001) and late (1.01, P = 0.004) AMD compared with mean MOD in the no-AMD stage (1.23).CONCLUSIONS. Foveal cones show signs of misalignment and/or outer segment deterioration in early AMD. Melanin rather than macular pigment may play a protective role against AMD, although loss of these ocular pigments can also be caused by AMD.

AB - PURPOSE. To establish the relation between AMD stage and a quantitative measure for the integrity of foveal cone photoreceptors related to the optical Stiles-Crawford effect.METHODS. Fifty-six AMD eyes and 57 control eyes were included in the final analysis. AMD was graded in accordance with the International Classification System into five mutually exclusive stages. Stages 0 to 1 were labeled no AMD, stages 2 to 3 were labeled early AMD, and stage 4 was labeled late AMD. Fundus reflectometry, together with a model-fit procedure, provided information on directional cone reflectance (Rd), a quantitative measure for the integrity of foveal cone photoreceptors. Optical densities of macular pigment (MPOD) and melanin (MOD) were also obtained. A general linear model analysis was used to compare Rd, MPOD, and MOD among the AMD stages.RESULTS. Mean Rd was lower in early AMD (0.92%, P <0.001) and late AMD (0.86%, P <0.001) compared with mean Rd in the no-AMD stage (1.76%). Mean MPOD was not different in early AMD (0.53, P = 0.05), but it was lower in late AMD (0.19, P <0.001) compared with mean MPOD in the no-AMD stage (0.42). Mean MOD was lower in early (1.09, P = 0.001) and late (1.01, P = 0.004) AMD compared with mean MOD in the no-AMD stage (1.23).CONCLUSIONS. Foveal cones show signs of misalignment and/or outer segment deterioration in early AMD. Melanin rather than macular pigment may play a protective role against AMD, although loss of these ocular pigments can also be caused by AMD.

KW - AGE-RELATED MACULOPATHY

KW - OPTICAL-DENSITY

KW - 10-YEAR INCIDENCE

KW - RISK-FACTORS

KW - DEGENERATION

KW - PIGMENT

KW - POPULATION

KW - DISEASE

KW - EYE

KW - REFLECTANCE

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U2 - 10.1167/iovs.07-1181

DO - 10.1167/iovs.07-1181

M3 - Article

C2 - 18223244

SN - 0146-0404

VL - 49

SP - 2077

EP - 2081

JO - Investigative ophthalmology & visual science

JF - Investigative ophthalmology & visual science

IS - 5

ER -

Foveal cone-photoreceptor integrity in aging macula disorder

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Keywords

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