Foveal cone-photoreceptor integrity in aging macula disorder

Martijn J. Kanis*, R. P L Wisse, T. T J M Berendschot, Jan Van De Kraats, Dirk Van Norren

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    12 Citations (Scopus)


    PURPOSE. To establish the relation between AMD stage and a quantitative measure for the integrity of foveal cone photoreceptors related to the optical Stiles-Crawford effect.

    METHODS. Fifty-six AMD eyes and 57 control eyes were included in the final analysis. AMD was graded in accordance with the International Classification System into five mutually exclusive stages. Stages 0 to 1 were labeled no AMD, stages 2 to 3 were labeled early AMD, and stage 4 was labeled late AMD. Fundus reflectometry, together with a model-fit procedure, provided information on directional cone reflectance (Rd), a quantitative measure for the integrity of foveal cone photoreceptors. Optical densities of macular pigment (MPOD) and melanin (MOD) were also obtained. A general linear model analysis was used to compare Rd, MPOD, and MOD among the AMD stages.

    RESULTS. Mean Rd was lower in early AMD (0.92%, P <0.001) and late AMD (0.86%, P <0.001) compared with mean Rd in the no-AMD stage (1.76%). Mean MPOD was not different in early AMD (0.53, P = 0.05), but it was lower in late AMD (0.19, P <0.001) compared with mean MPOD in the no-AMD stage (0.42). Mean MOD was lower in early (1.09, P = 0.001) and late (1.01, P = 0.004) AMD compared with mean MOD in the no-AMD stage (1.23).

    CONCLUSIONS. Foveal cones show signs of misalignment and/or outer segment deterioration in early AMD. Melanin rather than macular pigment may play a protective role against AMD, although loss of these ocular pigments can also be caused by AMD.

    Original languageEnglish
    Pages (from-to)2077-2081
    Number of pages5
    JournalInvestigative ophthalmology & visual science
    Issue number5
    Publication statusPublished - 2008


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