For genomes to stay in shape, insulators must be up to PAR.

P.J. Wijchers; W.L. de Laat

For genomes to stay in shape, insulators must be up to PAR.

Translated title of the contribution: For genomes to stay in shape, insulators must be up to PAR.

P.J. Wijchers
, W.L. de Laat

Cancer

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Insulators drive nuclear organization by blocking or facilitating interactions between DNA regulatory elements. Ong et al. show that poly(ADP-ribosyl)ation of insulator binding proteins modulates their ability to physically interact with distant regulatory elements, implicating posttranslational modifications of nonhistone proteins in genome architecture.

Translated title of the contribution	For genomes to stay in shape, insulators must be up to PAR.
Original language	Undefined/Unknown
Pages (from-to)	15-6
Number of pages	2
Journal	Cell
Volume	155
Issue number	1
Publication status	Published - 2013

Cite this

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title = "For genomes to stay in shape, insulators must be up to PAR.",

abstract = "Insulators drive nuclear organization by blocking or facilitating interactions between DNA regulatory elements. Ong et al. show that poly(ADP-ribosyl)ation of insulator binding proteins modulates their ability to physically interact with distant regulatory elements, implicating posttranslational modifications of nonhistone proteins in genome architecture.",

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AU - Wijchers, P.J.

AU - de Laat, W.L.

PY - 2013

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AB - Insulators drive nuclear organization by blocking or facilitating interactions between DNA regulatory elements. Ong et al. show that poly(ADP-ribosyl)ation of insulator binding proteins modulates their ability to physically interact with distant regulatory elements, implicating posttranslational modifications of nonhistone proteins in genome architecture.

M3 - Article

SN - 0092-8674

VL - 155

SP - 15

EP - 16

JO - Cell

JF - Cell

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ER -

For genomes to stay in shape, insulators must be up to PAR.

Abstract

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