Abstract
Insulators drive nuclear organization by blocking or facilitating interactions between DNA regulatory elements. Ong et al. show that poly(ADP-ribosyl)ation of insulator binding proteins modulates their ability to physically interact with distant regulatory elements, implicating posttranslational modifications of nonhistone proteins in genome architecture.
| Translated title of the contribution | For genomes to stay in shape, insulators must be up to PAR. |
|---|---|
| Original language | Undefined/Unknown |
| Pages (from-to) | 15-6 |
| Number of pages | 2 |
| Journal | Cell |
| Volume | 155 |
| Issue number | 1 |
| Publication status | Published - 2013 |