Food allergy in the Netherlands: differences in clinical severity, causative foods, sensitization and DBPCFC between community and outpatients

Thuy-My Le; Els van Hoffen; Ischa Kummeling; James Potts; Barbara K Ballmer-Weber; Carla Afm Bruijnzeel-Koomen; Ans Fm Lebens; Jonas Lidholm; Titia M Lindner; Alan Mackie; En Clare Mills; Ronald van Ree; Stefan Vieths; Montserrat Fernández-Rivas; Peter G Burney; André C Knulst

doi:10.1186/s13601-015-0051-1

Food allergy in the Netherlands: differences in clinical severity, causative foods, sensitization and DBPCFC between community and outpatients

Thuy-My Le, Els van Hoffen, Ischa Kummeling, James Potts, Barbara K Ballmer-Weber, Carla Afm Bruijnzeel-Koomen, Ans Fm Lebens, Jonas Lidholm, Titia M Lindner, Alan Mackie, En Clare Mills, Ronald van Ree, Stefan Vieths, Montserrat Fernández-Rivas, Peter G Burney, André C Knulst

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Abstract

BACKGROUND: It is unknown whether food allergy (FA) in an unselected population is comparable to those from an outpatient clinic population.

OBJECTIVE: To discover if FA in a random sample from the Dutch community is comparable to that of outpatients.

METHODS: This study was part of the Europrevall-project. A random sample of 6600 adults received a questionnaire. Those with symptoms to one of 24 defined priority foods were tested for sIgE. Participants with a positive case history and elevated sIgE were evaluated by double-blind placebo-controlled food challenge (DBPCFC). Outpatients with a suspicion of FA were evaluated by questionnaire, sIgE and DBPCFC.

RESULTS: In the community, severe symptoms were reported less often than in outpatients (39.3% vs. 54.3%). Participants in the community were less commonly sensitized to any of the foods. When selecting only those with a probable FA (i.e. symptoms of priority food and elevation of sIgE to the respective food), no major differences were observed with respect to severity, causative foods, sensitization and DBPCFC between the groups.

CONCLUSION: In the Netherlands, there are large differences in self-reported FA between community and outpatients. However, Dutch community and outpatients with a probable FA do not differ with respect to severity, causative foods, sensitization and DBPCFC-outcome.

Original language	English
Article number	5:8
Number of pages	8
Journal	Clinical and Translational Allergy
Volume	5
DOIs	https://doi.org/10.1186/s13601-015-0051-1
Publication status	Published - 2015

Keywords

Adults
Community
DBPCFC
Food allergy
sIgE

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Le, T.-M., van Hoffen, E., Kummeling, I., Potts, J., Ballmer-Weber, B. K., Bruijnzeel-Koomen, C. A., Lebens, A. F., Lidholm, J., Lindner, T. M., Mackie, A., Mills, E. C., van Ree, R., Vieths, S., Fernández-Rivas, M., Burney, P. G., & Knulst, A. C. (2015). Food allergy in the Netherlands: differences in clinical severity, causative foods, sensitization and DBPCFC between community and outpatients. Clinical and Translational Allergy, 5, Article 5:8. https://doi.org/10.1186/s13601-015-0051-1

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title = "Food allergy in the Netherlands: differences in clinical severity, causative foods, sensitization and DBPCFC between community and outpatients",

abstract = "BACKGROUND: It is unknown whether food allergy (FA) in an unselected population is comparable to those from an outpatient clinic population.OBJECTIVE: To discover if FA in a random sample from the Dutch community is comparable to that of outpatients.METHODS: This study was part of the Europrevall-project. A random sample of 6600 adults received a questionnaire. Those with symptoms to one of 24 defined priority foods were tested for sIgE. Participants with a positive case history and elevated sIgE were evaluated by double-blind placebo-controlled food challenge (DBPCFC). Outpatients with a suspicion of FA were evaluated by questionnaire, sIgE and DBPCFC.RESULTS: In the community, severe symptoms were reported less often than in outpatients (39.3% vs. 54.3%). Participants in the community were less commonly sensitized to any of the foods. When selecting only those with a probable FA (i.e. symptoms of priority food and elevation of sIgE to the respective food), no major differences were observed with respect to severity, causative foods, sensitization and DBPCFC between the groups.CONCLUSION: In the Netherlands, there are large differences in self-reported FA between community and outpatients. However, Dutch community and outpatients with a probable FA do not differ with respect to severity, causative foods, sensitization and DBPCFC-outcome.",

keywords = " Adults, Community, DBPCFC, Food allergy, sIgE",

author = "Thuy-My Le and {van Hoffen}, Els and Ischa Kummeling and James Potts and Ballmer-Weber, {Barbara K} and Bruijnzeel-Koomen, {Carla Afm} and Lebens, {Ans Fm} and Jonas Lidholm and Lindner, {Titia M} and Alan Mackie and Mills, {En Clare} and {van Ree}, Ronald and Stefan Vieths and Montserrat Fern{\'a}ndez-Rivas and Burney, {Peter G} and Knulst, {Andr{\'e} C}",

year = "2015",

doi = "10.1186/s13601-015-0051-1",

language = "English",

volume = "5",

journal = "Clinical and Translational Allergy",

issn = "2045-7022",

publisher = "BioMed Central",

}

Le, T-M, van Hoffen, E, Kummeling, I, Potts, J, Ballmer-Weber, BK, Bruijnzeel-Koomen, CA, Lebens, AF, Lidholm, J, Lindner, TM, Mackie, A, Mills, EC, van Ree, R, Vieths, S, Fernández-Rivas, M, Burney, PG & Knulst, AC 2015, 'Food allergy in the Netherlands: differences in clinical severity, causative foods, sensitization and DBPCFC between community and outpatients', Clinical and Translational Allergy, vol. 5, 5:8. https://doi.org/10.1186/s13601-015-0051-1

TY - JOUR

T1 - Food allergy in the Netherlands

T2 - differences in clinical severity, causative foods, sensitization and DBPCFC between community and outpatients

AU - Le, Thuy-My

AU - van Hoffen, Els

AU - Kummeling, Ischa

AU - Potts, James

AU - Ballmer-Weber, Barbara K

AU - Bruijnzeel-Koomen, Carla Afm

AU - Lebens, Ans Fm

AU - Lidholm, Jonas

AU - Lindner, Titia M

AU - Mackie, Alan

AU - Mills, En Clare

AU - van Ree, Ronald

AU - Vieths, Stefan

AU - Fernández-Rivas, Montserrat

AU - Burney, Peter G

AU - Knulst, André C

PY - 2015

Y1 - 2015

N2 - BACKGROUND: It is unknown whether food allergy (FA) in an unselected population is comparable to those from an outpatient clinic population.OBJECTIVE: To discover if FA in a random sample from the Dutch community is comparable to that of outpatients.METHODS: This study was part of the Europrevall-project. A random sample of 6600 adults received a questionnaire. Those with symptoms to one of 24 defined priority foods were tested for sIgE. Participants with a positive case history and elevated sIgE were evaluated by double-blind placebo-controlled food challenge (DBPCFC). Outpatients with a suspicion of FA were evaluated by questionnaire, sIgE and DBPCFC.RESULTS: In the community, severe symptoms were reported less often than in outpatients (39.3% vs. 54.3%). Participants in the community were less commonly sensitized to any of the foods. When selecting only those with a probable FA (i.e. symptoms of priority food and elevation of sIgE to the respective food), no major differences were observed with respect to severity, causative foods, sensitization and DBPCFC between the groups.CONCLUSION: In the Netherlands, there are large differences in self-reported FA between community and outpatients. However, Dutch community and outpatients with a probable FA do not differ with respect to severity, causative foods, sensitization and DBPCFC-outcome.

AB - BACKGROUND: It is unknown whether food allergy (FA) in an unselected population is comparable to those from an outpatient clinic population.OBJECTIVE: To discover if FA in a random sample from the Dutch community is comparable to that of outpatients.METHODS: This study was part of the Europrevall-project. A random sample of 6600 adults received a questionnaire. Those with symptoms to one of 24 defined priority foods were tested for sIgE. Participants with a positive case history and elevated sIgE were evaluated by double-blind placebo-controlled food challenge (DBPCFC). Outpatients with a suspicion of FA were evaluated by questionnaire, sIgE and DBPCFC.RESULTS: In the community, severe symptoms were reported less often than in outpatients (39.3% vs. 54.3%). Participants in the community were less commonly sensitized to any of the foods. When selecting only those with a probable FA (i.e. symptoms of priority food and elevation of sIgE to the respective food), no major differences were observed with respect to severity, causative foods, sensitization and DBPCFC between the groups.CONCLUSION: In the Netherlands, there are large differences in self-reported FA between community and outpatients. However, Dutch community and outpatients with a probable FA do not differ with respect to severity, causative foods, sensitization and DBPCFC-outcome.

KW - Adults

KW - Community

KW - DBPCFC

KW - Food allergy

KW - sIgE

U2 - 10.1186/s13601-015-0051-1

DO - 10.1186/s13601-015-0051-1

M3 - Article

C2 - 25774288

SN - 2045-7022

VL - 5

JO - Clinical and Translational Allergy

JF - Clinical and Translational Allergy

M1 - 5:8

ER -

Food allergy in the Netherlands: differences in clinical severity, causative foods, sensitization and DBPCFC between community and outpatients

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Keywords

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