Focal ischemia in cat brain as studied by diffusion-weighted and dynamic susceptibility-contrast magnetic resonance imaging

H. B. Verheul; K. S. Tamminga; R. M. Dijkhuizen; J. W.Berkelbach van der Sprenkel; C. A.F. Tulleken; K. Nicolay

doi:10.1007/BF01705274

Focal ischemia in cat brain as studied by diffusion-weighted and dynamic susceptibility-contrast magnetic resonance imaging

H. B. Verheul, K. S. Tamminga, R. M. Dijkhuizen, J. W.Berkelbach van der Sprenkel, C. A.F. Tulleken, K. Nicolay^*

^*Corresponding author for this work

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3 Citations (Scopus)

Abstract

Diffusion-weighted and susceptibility-contrast-enhanced magnetic resonance imaging were used to monitor the development of focal ischemia in cat brain. Diffusion-sensitized imaging was used to assess early ischemic tissue damage which was confirmed for the latest time point (∼12 h) with postmortem histological analysis. T*₂-sensitized FLASH was used to measure the first passage of a bolus of FeO particles. Gamma function fitting of ΔR*₂-time curves resulted in 2D maps of relative hemodynamic parameters, including cerebral blood volume and flow. The present data provide indications for cerebral blood flow thresholds for acute as well as for delayed ischemic tissue damage.

Original language	English
Pages (from-to)	367-370
Number of pages	4
Journal	Magma: Magnetic Resonance Materials in Physics, Biology, and Medicine
Volume	2
Issue number	3
DOIs	https://doi.org/10.1007/BF01705274
Publication status	Published - 1 Oct 1994

Keywords

blood flow
brain
cat
diffusion-weighted MRI
ischemia
susceptibility contrast MRI

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10.1007/BF01705274

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title = "Focal ischemia in cat brain as studied by diffusion-weighted and dynamic susceptibility-contrast magnetic resonance imaging",

abstract = "Diffusion-weighted and susceptibility-contrast-enhanced magnetic resonance imaging were used to monitor the development of focal ischemia in cat brain. Diffusion-sensitized imaging was used to assess early ischemic tissue damage which was confirmed for the latest time point (∼12 h) with postmortem histological analysis. T*2-sensitized FLASH was used to measure the first passage of a bolus of FeO particles. Gamma function fitting of ΔR*2-time curves resulted in 2D maps of relative hemodynamic parameters, including cerebral blood volume and flow. The present data provide indications for cerebral blood flow thresholds for acute as well as for delayed ischemic tissue damage.",

keywords = "blood flow, brain, cat, diffusion-weighted MRI, ischemia, susceptibility contrast MRI",

author = "Verheul, {H. B.} and Tamminga, {K. S.} and Dijkhuizen, {R. M.} and {van der Sprenkel}, {J. W.Berkelbach} and Tulleken, {C. A.F.} and K. Nicolay",

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doi = "10.1007/BF01705274",

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Focal ischemia in cat brain as studied by diffusion-weighted and dynamic susceptibility-contrast magnetic resonance imaging. / Verheul, H. B.; Tamminga, K. S.; Dijkhuizen, R. M. et al.
In: Magma: Magnetic Resonance Materials in Physics, Biology, and Medicine, Vol. 2, No. 3, 01.10.1994, p. 367-370.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Focal ischemia in cat brain as studied by diffusion-weighted and dynamic susceptibility-contrast magnetic resonance imaging

AU - Verheul, H. B.

AU - Tamminga, K. S.

AU - Dijkhuizen, R. M.

AU - van der Sprenkel, J. W.Berkelbach

AU - Tulleken, C. A.F.

AU - Nicolay, K.

PY - 1994/10/1

Y1 - 1994/10/1

N2 - Diffusion-weighted and susceptibility-contrast-enhanced magnetic resonance imaging were used to monitor the development of focal ischemia in cat brain. Diffusion-sensitized imaging was used to assess early ischemic tissue damage which was confirmed for the latest time point (∼12 h) with postmortem histological analysis. T*2-sensitized FLASH was used to measure the first passage of a bolus of FeO particles. Gamma function fitting of ΔR*2-time curves resulted in 2D maps of relative hemodynamic parameters, including cerebral blood volume and flow. The present data provide indications for cerebral blood flow thresholds for acute as well as for delayed ischemic tissue damage.

AB - Diffusion-weighted and susceptibility-contrast-enhanced magnetic resonance imaging were used to monitor the development of focal ischemia in cat brain. Diffusion-sensitized imaging was used to assess early ischemic tissue damage which was confirmed for the latest time point (∼12 h) with postmortem histological analysis. T*2-sensitized FLASH was used to measure the first passage of a bolus of FeO particles. Gamma function fitting of ΔR*2-time curves resulted in 2D maps of relative hemodynamic parameters, including cerebral blood volume and flow. The present data provide indications for cerebral blood flow thresholds for acute as well as for delayed ischemic tissue damage.

KW - blood flow

KW - brain

KW - cat

KW - diffusion-weighted MRI

KW - ischemia

KW - susceptibility contrast MRI

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JF - Magma: Magnetic Resonance Materials in Physics, Biology, and Medicine

IS - 3

ER -

Focal ischemia in cat brain as studied by diffusion-weighted and dynamic susceptibility-contrast magnetic resonance imaging

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Keywords

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