Fluorine-18 fluorodeoxyglucose positron emission tomography (PET) to detect vital retinoblastoma in the eye: Preliminary experience

A. C. Moll; O. S. Hoekstra; S. M. Imhof; E. F. Comans; A. Y N Schouten-Van Meeteren; P. Van Der Valk; M. Boers

doi:10.1076/opge.25.1.31.29001

Fluorine-18 fluorodeoxyglucose positron emission tomography (PET) to detect vital retinoblastoma in the eye: Preliminary experience

A. C. Moll^*, O. S. Hoekstra, S. M. Imhof, E. F. Comans, A. Y N Schouten-Van Meeteren, P. Van Der Valk, M. Boers

^*Corresponding author for this work

Infection & Immunity

Research output: Contribution to journal › Article › Academic › peer-review

19 Citations (Scopus)

Abstract

Background/aims: To report our first experience with FDG-PET in the detection of vital retinoblastoma. Methods: Four newly diagnosed retinoblastoma patients, two treated retinoblastoma patients, and four control patients were enrolled in this pilot study. F18-FDG uptake was assessed in the light of clinical and histopathological features. Results: PET discriminated between new patients and controls, although tumor uptake varied widely. PET added no useful information with regard to possible vital tissue in tumor scars in the eye of the two treated retinoblastoma patients. Moreover, PET findings did not correlate with clinical or histopathological features. Conclusion: Based on this small pilot study, F18-PET shows little promise in the detection of retinoblastoma. More research on other radiofarmacons is recommended.

Original language	English
Pages (from-to)	31-35
Number of pages	5
Journal	Ophthalmic Genetics
Volume	25
Issue number	1
DOIs	https://doi.org/10.1076/opge.25.1.31.29001
Publication status	Published - 1 Mar 2004

Keywords

Positron emission tomography (PET)
Retinoblastoma

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10.1076/opge.25.1.31.29001

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title = "Fluorine-18 fluorodeoxyglucose positron emission tomography (PET) to detect vital retinoblastoma in the eye: Preliminary experience",

abstract = "Background/aims: To report our first experience with FDG-PET in the detection of vital retinoblastoma. Methods: Four newly diagnosed retinoblastoma patients, two treated retinoblastoma patients, and four control patients were enrolled in this pilot study. F18-FDG uptake was assessed in the light of clinical and histopathological features. Results: PET discriminated between new patients and controls, although tumor uptake varied widely. PET added no useful information with regard to possible vital tissue in tumor scars in the eye of the two treated retinoblastoma patients. Moreover, PET findings did not correlate with clinical or histopathological features. Conclusion: Based on this small pilot study, F18-PET shows little promise in the detection of retinoblastoma. More research on other radiofarmacons is recommended.",

keywords = "Positron emission tomography (PET), Retinoblastoma",

author = "Moll, {A. C.} and Hoekstra, {O. S.} and Imhof, {S. M.} and Comans, {E. F.} and {Schouten-Van Meeteren}, {A. Y N} and {Van Der Valk}, P. and M. Boers",

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doi = "10.1076/opge.25.1.31.29001",

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T1 - Fluorine-18 fluorodeoxyglucose positron emission tomography (PET) to detect vital retinoblastoma in the eye

T2 - Preliminary experience

AU - Moll, A. C.

AU - Hoekstra, O. S.

AU - Imhof, S. M.

AU - Comans, E. F.

AU - Schouten-Van Meeteren, A. Y N

AU - Van Der Valk, P.

AU - Boers, M.

PY - 2004/3/1

Y1 - 2004/3/1

N2 - Background/aims: To report our first experience with FDG-PET in the detection of vital retinoblastoma. Methods: Four newly diagnosed retinoblastoma patients, two treated retinoblastoma patients, and four control patients were enrolled in this pilot study. F18-FDG uptake was assessed in the light of clinical and histopathological features. Results: PET discriminated between new patients and controls, although tumor uptake varied widely. PET added no useful information with regard to possible vital tissue in tumor scars in the eye of the two treated retinoblastoma patients. Moreover, PET findings did not correlate with clinical or histopathological features. Conclusion: Based on this small pilot study, F18-PET shows little promise in the detection of retinoblastoma. More research on other radiofarmacons is recommended.

AB - Background/aims: To report our first experience with FDG-PET in the detection of vital retinoblastoma. Methods: Four newly diagnosed retinoblastoma patients, two treated retinoblastoma patients, and four control patients were enrolled in this pilot study. F18-FDG uptake was assessed in the light of clinical and histopathological features. Results: PET discriminated between new patients and controls, although tumor uptake varied widely. PET added no useful information with regard to possible vital tissue in tumor scars in the eye of the two treated retinoblastoma patients. Moreover, PET findings did not correlate with clinical or histopathological features. Conclusion: Based on this small pilot study, F18-PET shows little promise in the detection of retinoblastoma. More research on other radiofarmacons is recommended.

KW - Positron emission tomography (PET)

KW - Retinoblastoma

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Fluorine-18 fluorodeoxyglucose positron emission tomography (PET) to detect vital retinoblastoma in the eye: Preliminary experience

Abstract

Keywords

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