Fluorescence of neutrophil granulocytes as a biomarker for clozapine use

Wai Hong Man; Maarten ten Berg; Ingeborg Wilting; Albert Huisman; Wiepke Cahn; Jan Willem Douma; Hanneke den Breeijen; Eibert R. Heerdink; Toine Egberts; Wouter van Solinge

doi:10.1016/j.euroneuro.2013.08.005

Fluorescence of neutrophil granulocytes as a biomarker for clozapine use

Wai Hong Man, Maarten ten Berg, Ingeborg Wilting, Albert Huisman, Wiepke Cahn, Jan Willem Douma, Hanneke den Breeijen, Eibert R. Heerdink, Toine Egberts, Wouter van Solinge^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Non-adherence to medication is a major issue in the treatment of schizophrenia in general and in particular for those treated with clozapine. A reliable tool to quantify patients long-term adherence to clozapine is currently unavailable. Enhanced FL3 neutrophil granulocyte fluorescence was serendipitously observed in a small population of schizophrenic patients treated with clozapine. The present study was aimed at assessing the association between clozapine use and FL3-fluorescence.

A cross-sectional study was performed using data from the Utrecht Patient Oriented Database (UPOD). A total of 38,390 inpatients were included, of which 124 (0.33%) used clozapine. FL3-fluorescence was significantly higher (U=240, 179, P

Our results confirm the association between use of clozapine and elevated FL3-fluorescence. Further research is needed to unravel the underlying mechanism and to investigate the true potential of FL3-fluorescence as a clozapine-adherence biomarker in clinical practice. (C) 2013 Elsevier B.V. and ECNP. All rights reserved.

Original language	English
Pages (from-to)	1408-1413
Number of pages	6
Journal	European Neuropsychopharmacology
Volume	23
Issue number	11
DOIs	https://doi.org/10.1016/j.euroneuro.2013.08.005
Publication status	Published - Nov 2013

Keywords

Biomarker
Clozapine
FL3-fluorescence
Medication adherence
Neutrophil granulocytes
Schizophrenia

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10.1016/j.euroneuro.2013.08.005

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title = "Fluorescence of neutrophil granulocytes as a biomarker for clozapine use",

abstract = "Non-adherence to medication is a major issue in the treatment of schizophrenia in general and in particular for those treated with clozapine. A reliable tool to quantify patients long-term adherence to clozapine is currently unavailable. Enhanced FL3 neutrophil granulocyte fluorescence was serendipitously observed in a small population of schizophrenic patients treated with clozapine. The present study was aimed at assessing the association between clozapine use and FL3-fluorescence.A cross-sectional study was performed using data from the Utrecht Patient Oriented Database (UPOD). A total of 38,390 inpatients were included, of which 124 (0.33%) used clozapine. FL3-fluorescence was significantly higher (U=240, 179, POur results confirm the association between use of clozapine and elevated FL3-fluorescence. Further research is needed to unravel the underlying mechanism and to investigate the true potential of FL3-fluorescence as a clozapine-adherence biomarker in clinical practice. (C) 2013 Elsevier B.V. and ECNP. All rights reserved.",

keywords = "Biomarker, Clozapine, FL3-fluorescence, Medication adherence, Neutrophil granulocytes, Schizophrenia",

author = "Man, {Wai Hong} and {ten Berg}, Maarten and Ingeborg Wilting and Albert Huisman and Wiepke Cahn and Douma, {Jan Willem} and {den Breeijen}, Hanneke and Heerdink, {Eibert R.} and Toine Egberts and {van Solinge}, Wouter",

year = "2013",

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doi = "10.1016/j.euroneuro.2013.08.005",

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AU - Man, Wai Hong

AU - ten Berg, Maarten

AU - Wilting, Ingeborg

AU - Huisman, Albert

AU - Cahn, Wiepke

AU - Douma, Jan Willem

AU - den Breeijen, Hanneke

AU - Heerdink, Eibert R.

AU - Egberts, Toine

AU - van Solinge, Wouter

PY - 2013/11

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N2 - Non-adherence to medication is a major issue in the treatment of schizophrenia in general and in particular for those treated with clozapine. A reliable tool to quantify patients long-term adherence to clozapine is currently unavailable. Enhanced FL3 neutrophil granulocyte fluorescence was serendipitously observed in a small population of schizophrenic patients treated with clozapine. The present study was aimed at assessing the association between clozapine use and FL3-fluorescence.A cross-sectional study was performed using data from the Utrecht Patient Oriented Database (UPOD). A total of 38,390 inpatients were included, of which 124 (0.33%) used clozapine. FL3-fluorescence was significantly higher (U=240, 179, POur results confirm the association between use of clozapine and elevated FL3-fluorescence. Further research is needed to unravel the underlying mechanism and to investigate the true potential of FL3-fluorescence as a clozapine-adherence biomarker in clinical practice. (C) 2013 Elsevier B.V. and ECNP. All rights reserved.

AB - Non-adherence to medication is a major issue in the treatment of schizophrenia in general and in particular for those treated with clozapine. A reliable tool to quantify patients long-term adherence to clozapine is currently unavailable. Enhanced FL3 neutrophil granulocyte fluorescence was serendipitously observed in a small population of schizophrenic patients treated with clozapine. The present study was aimed at assessing the association between clozapine use and FL3-fluorescence.A cross-sectional study was performed using data from the Utrecht Patient Oriented Database (UPOD). A total of 38,390 inpatients were included, of which 124 (0.33%) used clozapine. FL3-fluorescence was significantly higher (U=240, 179, POur results confirm the association between use of clozapine and elevated FL3-fluorescence. Further research is needed to unravel the underlying mechanism and to investigate the true potential of FL3-fluorescence as a clozapine-adherence biomarker in clinical practice. (C) 2013 Elsevier B.V. and ECNP. All rights reserved.

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KW - Medication adherence

KW - Neutrophil granulocytes

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ER -

Fluorescence of neutrophil granulocytes as a biomarker for clozapine use

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Keywords

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