Fighting antibiotic resistance in the intensive care unit using antibiotics

Nienke L. Plantinga; Bastiaan H J Wittekamp; Pleun J. Van Duijn; Marc J M Bonten

doi:10.2217/FMB.14.146

Fighting antibiotic resistance in the intensive care unit using antibiotics

Nienke L. Plantinga, Bastiaan H J Wittekamp^*, Pleun J. Van Duijn, Marc J M Bonten

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Antibiotic resistance is a global and increasing problem that is not counterbalanced by the development of new therapeutic agents. The prevalence of antibiotic resistance is especially high in intensive care units with frequently reported outbreaks of multidrug-resistant organisms. In addition to classical infection prevention protocols and surveillance programs, counterintuitive interventions, such as selective decontamination with antibiotics and antibiotic rotation have been applied and investigated to control the emergence of antibiotic resistance. This review provides an overview of selective oropharyngeal and digestive tract decontamination, decolonization of methicillin-resistant Staphylococcus aureus and antibiotic rotation as strategies to modulate antibiotic resistance in the intensive care unit.

Original language	English
Pages (from-to)	391-406
Number of pages	16
Journal	Future microbiology
Volume	10
Issue number	3
DOIs	https://doi.org/10.2217/FMB.14.146
Publication status	Published - 1 Jan 2015

Keywords

Antibiotic resistance
Antibiotic rotation
Cycling
Decolonization
Intensive care unit
Mixing
Multidrug-resistant bacteria
Selective decontamination

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10.2217/FMB.14.146

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title = "Fighting antibiotic resistance in the intensive care unit using antibiotics",

abstract = "Antibiotic resistance is a global and increasing problem that is not counterbalanced by the development of new therapeutic agents. The prevalence of antibiotic resistance is especially high in intensive care units with frequently reported outbreaks of multidrug-resistant organisms. In addition to classical infection prevention protocols and surveillance programs, counterintuitive interventions, such as selective decontamination with antibiotics and antibiotic rotation have been applied and investigated to control the emergence of antibiotic resistance. This review provides an overview of selective oropharyngeal and digestive tract decontamination, decolonization of methicillin-resistant Staphylococcus aureus and antibiotic rotation as strategies to modulate antibiotic resistance in the intensive care unit.",

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AU - Van Duijn, Pleun J.

AU - Bonten, Marc J M

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AB - Antibiotic resistance is a global and increasing problem that is not counterbalanced by the development of new therapeutic agents. The prevalence of antibiotic resistance is especially high in intensive care units with frequently reported outbreaks of multidrug-resistant organisms. In addition to classical infection prevention protocols and surveillance programs, counterintuitive interventions, such as selective decontamination with antibiotics and antibiotic rotation have been applied and investigated to control the emergence of antibiotic resistance. This review provides an overview of selective oropharyngeal and digestive tract decontamination, decolonization of methicillin-resistant Staphylococcus aureus and antibiotic rotation as strategies to modulate antibiotic resistance in the intensive care unit.

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Fighting antibiotic resistance in the intensive care unit using antibiotics

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Keywords

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