Fibronectin is a hypoxia-independent target of the tumor suppressor VHL

J.A.R. Bluijssen, M.P.J.K. Lolkema, M. van Beest, M. Boone, C.M.J.T. Snijckers, M. Los, M.F.B.G. Gebbink, B. Braam, F.C.P. Holstege, R.H. Giles, E.E. Voest

Research output: Contribution to journalArticleAcademicpeer-review


The von Hippel-Lindau (VHL) tumor suppressor gene regulates the extracellular matrix by controlling fibronectin deposition. To identify novel VHL target genes, we subjected mRNA from VHL-deficient RCC cells (786-0-pRC) and a transfectant re-expressing wildtype VHL (786-0-VHL) to differential expression profiling. Among the differentially expressed genes, we detected that fibronectin is upregulated in the presence of VHL, while it is not affected by hypoxia. Thus regulation of fibronectin deposition by VHL occurs at the transcriptional level, irrespective of oxygen levels.

Original languageEnglish
Pages (from-to)137-142
Number of pages6
JournalFEBS letters
Issue number1-3
Publication statusPublished - 2 Jan 2004


  • Carcinoma, Renal Cell
  • Cell Hypoxia
  • Ceruloplasmin
  • Fibronectins
  • Gene Expression Profiling
  • Gene Expression Regulation, Neoplastic
  • Genes, Tumor Suppressor
  • Humans
  • Insulin-Like Growth Factor Binding Protein 3
  • RNA, Messenger
  • Recombinant Proteins
  • Transcription, Genetic
  • Transfection
  • Tumor Cells, Cultured
  • Tumor Suppressor Proteins
  • Ubiquitin-Protein Ligases
  • Up-Regulation
  • Vascular Endothelial Growth Factors
  • Von Hippel-Lindau Tumor Suppressor Protein


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