Features of (reverse) remodeling in heart failure

M.E.I. Schipper

Features of (reverse) remodeling in heart failure

M.E.I. Schipper

Research output: Thesis › Doctoral thesis 1 (Research UU / Graduation UU)

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Abstract

The heart of end stage heart failure patients was the subject of this study. On tissue level the remodeling proces, developing in progressive heart failure, is characterized by hypertrophy of cardiomyocytes and interstitial fibrosis. During mechanical support 'reverse' remodeling is observed with (partial) normalisation of cardiomyocytes and extracellular matrix. The aim of this study was to obtain biological parameters giving information about the (reverse) remodeling status of the diseased myocardium and the possibility to influence these processes successfully.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	University Medical Center (UMC) Utrecht
Supervisors/Advisors	Lahpor, JR, Primary supervisor van Dijk, Marijke, Supervisor de Weger, RA, Co-supervisor de Jonge, N, Co-supervisor
Award date	27 Feb 2014
Publisher	Utrecht University
Print ISBNs	978-90-8891-827-8
Publication status	Published - 27 Feb 2014

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abstract = "The heart of end stage heart failure patients was the subject of this study. On tissue level the remodeling proces, developing in progressive heart failure, is characterized by hypertrophy of cardiomyocytes and interstitial fibrosis. During mechanical support 'reverse' remodeling is observed with (partial) normalisation of cardiomyocytes and extracellular matrix. The aim of this study was to obtain biological parameters giving information about the (reverse) remodeling status of the diseased myocardium and the possibility to influence these processes successfully.",

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AB - The heart of end stage heart failure patients was the subject of this study. On tissue level the remodeling proces, developing in progressive heart failure, is characterized by hypertrophy of cardiomyocytes and interstitial fibrosis. During mechanical support 'reverse' remodeling is observed with (partial) normalisation of cardiomyocytes and extracellular matrix. The aim of this study was to obtain biological parameters giving information about the (reverse) remodeling status of the diseased myocardium and the possibility to influence these processes successfully.

M3 - Doctoral thesis 1 (Research UU / Graduation UU)

SN - 978-90-8891-827-8

PB - Utrecht University

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Features of (reverse) remodeling in heart failure

Abstract

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