Abstract
RSV infections are a major burden in infants less than 3 months of age. Newborns and infants express a distinct immune system that is largely dependent on innate immunity and passive immunity from maternal antibodies. Antibodies can regulate immune responses against viruses through interaction with Fc gamma receptors leading to enhancement or neutralization of viral infections. The mechanisms underlying the immunomodulatory effect of Fc gamma receptors on viral infections have yet to be elucidated in infants. Herein, we will discuss current knowledge of the effects of antibodies and Fc gamma receptors on infant innate immunity to RSV. A better understanding of the pathogenesis of RSV infections in young infants may provide insight into novel therapeutic strategies such as vaccination.
Original language | English |
---|---|
Pages (from-to) | 55-70 |
Number of pages | 16 |
Journal | Reviews in medical virology |
Volume | 24 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2014 |
Externally published | Yes |
Keywords
- Antibodies, Viral/immunology
- Humans
- Immunity, Innate
- Infant
- Infant, Newborn
- Receptors, IgG/immunology
- Respiratory Syncytial Virus Infections/immunology
- Respiratory Syncytial Virus, Human/immunology