Fc gamma receptors in respiratory syncytial virus infections: implications for innate immunity

Jop Jans; Marloes Vissers; Jacco G M Heldens; Marien I de Jonge; Ofer Levy; Gerben Ferwerda

doi:10.1002/rmv.1773

Fc gamma receptors in respiratory syncytial virus infections: implications for innate immunity

Jop Jans, Marloes Vissers, Jacco G M Heldens, Marien I de Jonge, Ofer Levy, Gerben Ferwerda^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

RSV infections are a major burden in infants less than 3 months of age. Newborns and infants express a distinct immune system that is largely dependent on innate immunity and passive immunity from maternal antibodies. Antibodies can regulate immune responses against viruses through interaction with Fc gamma receptors leading to enhancement or neutralization of viral infections. The mechanisms underlying the immunomodulatory effect of Fc gamma receptors on viral infections have yet to be elucidated in infants. Herein, we will discuss current knowledge of the effects of antibodies and Fc gamma receptors on infant innate immunity to RSV. A better understanding of the pathogenesis of RSV infections in young infants may provide insight into novel therapeutic strategies such as vaccination.

Original language	English
Pages (from-to)	55-70
Number of pages	16
Journal	Reviews in medical virology
Volume	24
Issue number	1
DOIs	https://doi.org/10.1002/rmv.1773
Publication status	Published - Jan 2014
Externally published	Yes

Keywords

Antibodies, Viral/immunology
Humans
Immunity, Innate
Infant
Infant, Newborn
Receptors, IgG/immunology
Respiratory Syncytial Virus Infections/immunology
Respiratory Syncytial Virus, Human/immunology

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10.1002/rmv.1773

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title = "Fc gamma receptors in respiratory syncytial virus infections: implications for innate immunity",

abstract = "RSV infections are a major burden in infants less than 3 months of age. Newborns and infants express a distinct immune system that is largely dependent on innate immunity and passive immunity from maternal antibodies. Antibodies can regulate immune responses against viruses through interaction with Fc gamma receptors leading to enhancement or neutralization of viral infections. The mechanisms underlying the immunomodulatory effect of Fc gamma receptors on viral infections have yet to be elucidated in infants. Herein, we will discuss current knowledge of the effects of antibodies and Fc gamma receptors on infant innate immunity to RSV. A better understanding of the pathogenesis of RSV infections in young infants may provide insight into novel therapeutic strategies such as vaccination.",

keywords = "Antibodies, Viral/immunology, Humans, Immunity, Innate, Infant, Infant, Newborn, Receptors, IgG/immunology, Respiratory Syncytial Virus Infections/immunology, Respiratory Syncytial Virus, Human/immunology",

author = "Jop Jans and Marloes Vissers and Heldens, {Jacco G M} and {de Jonge}, {Marien I} and Ofer Levy and Gerben Ferwerda",

note = "Copyright {\textcopyright} 2013 John Wiley & Sons, Ltd.",

year = "2014",

month = jan,

doi = "10.1002/rmv.1773",

language = "English",

volume = "24",

pages = "55--70",

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issn = "1052-9276",

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TY - JOUR

T1 - Fc gamma receptors in respiratory syncytial virus infections

T2 - implications for innate immunity

AU - Jans, Jop

AU - Vissers, Marloes

AU - Heldens, Jacco G M

AU - de Jonge, Marien I

AU - Levy, Ofer

AU - Ferwerda, Gerben

PY - 2014/1

Y1 - 2014/1

N2 - RSV infections are a major burden in infants less than 3 months of age. Newborns and infants express a distinct immune system that is largely dependent on innate immunity and passive immunity from maternal antibodies. Antibodies can regulate immune responses against viruses through interaction with Fc gamma receptors leading to enhancement or neutralization of viral infections. The mechanisms underlying the immunomodulatory effect of Fc gamma receptors on viral infections have yet to be elucidated in infants. Herein, we will discuss current knowledge of the effects of antibodies and Fc gamma receptors on infant innate immunity to RSV. A better understanding of the pathogenesis of RSV infections in young infants may provide insight into novel therapeutic strategies such as vaccination.

AB - RSV infections are a major burden in infants less than 3 months of age. Newborns and infants express a distinct immune system that is largely dependent on innate immunity and passive immunity from maternal antibodies. Antibodies can regulate immune responses against viruses through interaction with Fc gamma receptors leading to enhancement or neutralization of viral infections. The mechanisms underlying the immunomodulatory effect of Fc gamma receptors on viral infections have yet to be elucidated in infants. Herein, we will discuss current knowledge of the effects of antibodies and Fc gamma receptors on infant innate immunity to RSV. A better understanding of the pathogenesis of RSV infections in young infants may provide insight into novel therapeutic strategies such as vaccination.

KW - Antibodies, Viral/immunology

KW - Humans

KW - Immunity, Innate

KW - Infant

KW - Infant, Newborn

KW - Receptors, IgG/immunology

KW - Respiratory Syncytial Virus Infections/immunology

KW - Respiratory Syncytial Virus, Human/immunology

U2 - 10.1002/rmv.1773

DO - 10.1002/rmv.1773

M3 - Review article

C2 - 24227634

SN - 1052-9276

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EP - 70

JO - Reviews in medical virology

JF - Reviews in medical virology

IS - 1

ER -

Fc gamma receptors in respiratory syncytial virus infections: implications for innate immunity

Abstract

Keywords

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