TY - JOUR
T1 - Fcã receptor iia (cd32) heterogeneity in patients with recurrent bacterial respiratory tract infections
AU - Sanders, Lieke A.M.
AU - Van de Winkel, Jan G.J.
AU - Rijkers, Ger T.
AU - Voorhorst-Ogink, Marleen M.
AU - De Haas, Masja
AU - Capel, Peter J.A.
AU - Zegers, Ben J.M.
PY - 1994/10
Y1 - 1994/10
N2 - Fc-ãRIIa (CD32) is the sole IgG Fc receptor capable ofinteraction with human IgG2, the main IgG subclass of bacterial capsular polysaccharides. The two genetically determined allotypes of human Fc-ãRIIa, Fc-ãRIIa-R131 and IIa-H 131 alleles, have functionally different reactivities with human IgG2. The capacity of polymorphonuclear leukocytes (PMNL) homozygous for Fc-ãRIIa-H/HI31 for IgG2 opsonized bacteria is significantly higher than phagocytosis by PMNL homozygous for Fc-ãRIIa-R/R131, independent of the Fc-ãRIIIb-NA1/NA2 (CDI6) allelic polymorphism. To test the clinical significance of these FcãR polymorphisms, Fc-ãRIIa and Fc-ãRIIIb phenotypes of 48 children with recurrent bacterial respiratory tract infections were determined. Fc-ãRIIa-H/HI31 was less than half that observed in 123 healthy adults (P = 01) IgG2 responses were low in 25 of 48 patients after immunization with pneumococcal vaccine. These results suggest that Fc-ãRIIa polymorphism may contribute to increased susceptibility to infections with encapsulated bacteria in a childhood population with low IgG2 anti-carbohydrate antibodies.
AB - Fc-ãRIIa (CD32) is the sole IgG Fc receptor capable ofinteraction with human IgG2, the main IgG subclass of bacterial capsular polysaccharides. The two genetically determined allotypes of human Fc-ãRIIa, Fc-ãRIIa-R131 and IIa-H 131 alleles, have functionally different reactivities with human IgG2. The capacity of polymorphonuclear leukocytes (PMNL) homozygous for Fc-ãRIIa-H/HI31 for IgG2 opsonized bacteria is significantly higher than phagocytosis by PMNL homozygous for Fc-ãRIIa-R/R131, independent of the Fc-ãRIIIb-NA1/NA2 (CDI6) allelic polymorphism. To test the clinical significance of these FcãR polymorphisms, Fc-ãRIIa and Fc-ãRIIIb phenotypes of 48 children with recurrent bacterial respiratory tract infections were determined. Fc-ãRIIa-H/HI31 was less than half that observed in 123 healthy adults (P = 01) IgG2 responses were low in 25 of 48 patients after immunization with pneumococcal vaccine. These results suggest that Fc-ãRIIa polymorphism may contribute to increased susceptibility to infections with encapsulated bacteria in a childhood population with low IgG2 anti-carbohydrate antibodies.
UR - http://www.scopus.com/inward/record.url?scp=0028169269&partnerID=8YFLogxK
U2 - 10.1093/infdis/170.4.854
DO - 10.1093/infdis/170.4.854
M3 - Article
C2 - 7930727
AN - SCOPUS:0028169269
SN - 0022-1899
VL - 170
SP - 854
EP - 861
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 4
ER -