Favorable outcome of neonatal cerebrospinal fluid shunt-associated Candida meningitis with caspofungin

Jop Jans; Roger J M Brüggemann; V Christmann; Paul E Verweij; Adilia Warris

doi:10.1128/AAC.02085-12

Favorable outcome of neonatal cerebrospinal fluid shunt-associated Candida meningitis with caspofungin

Jop Jans, Roger J M Brüggemann, V Christmann, Paul E Verweij, Adilia Warris^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Invasive Candida infections associated with medical devices are very difficult to cure without device removal. We present a case of neonatal cerebrospinal fluid shunt-associated Candida meningitis, in which removal of the device was precluded, that was successfully treated with caspofungin. Pharmacokinetic assessment of caspofungin concentrations in cerebrospinal fluid showed that exposure was adequate in the presence of a high systemic exposure. In complex cases of neonatal Candida infections involving medical devices, the addition of caspofungin might be beneficial.

Original language	English
Pages (from-to)	2391-3
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	57
Issue number	5
DOIs	https://doi.org/10.1128/AAC.02085-12
Publication status	Published - May 2013
Externally published	Yes

Keywords

Antifungal Agents/therapeutic use
Candida albicans/drug effects
Candidiasis/drug therapy
Caspofungin
Cerebrospinal Fluid Shunts/adverse effects
Echinocandins/therapeutic use
Humans
Infant, Newborn
Infant, Premature
Lipopeptides
Male
Treatment Outcome

Access to Document

10.1128/AAC.02085-12

Cite this

@article{8096bc6855af46159168f48c63954e9f,

title = "Favorable outcome of neonatal cerebrospinal fluid shunt-associated Candida meningitis with caspofungin",

abstract = "Invasive Candida infections associated with medical devices are very difficult to cure without device removal. We present a case of neonatal cerebrospinal fluid shunt-associated Candida meningitis, in which removal of the device was precluded, that was successfully treated with caspofungin. Pharmacokinetic assessment of caspofungin concentrations in cerebrospinal fluid showed that exposure was adequate in the presence of a high systemic exposure. In complex cases of neonatal Candida infections involving medical devices, the addition of caspofungin might be beneficial.",

keywords = "Antifungal Agents/therapeutic use, Candida albicans/drug effects, Candidiasis/drug therapy, Caspofungin, Cerebrospinal Fluid Shunts/adverse effects, Echinocandins/therapeutic use, Humans, Infant, Newborn, Infant, Premature, Lipopeptides, Male, Treatment Outcome",

author = "Jop Jans and Br{\"u}ggemann, {Roger J M} and V Christmann and Verweij, {Paul E} and Adilia Warris",

year = "2013",

month = may,

doi = "10.1128/AAC.02085-12",

language = "English",

volume = "57",

pages = "2391--3",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "5",

}

TY - JOUR

T1 - Favorable outcome of neonatal cerebrospinal fluid shunt-associated Candida meningitis with caspofungin

AU - Jans, Jop

AU - Brüggemann, Roger J M

AU - Christmann, V

AU - Verweij, Paul E

AU - Warris, Adilia

PY - 2013/5

Y1 - 2013/5

N2 - Invasive Candida infections associated with medical devices are very difficult to cure without device removal. We present a case of neonatal cerebrospinal fluid shunt-associated Candida meningitis, in which removal of the device was precluded, that was successfully treated with caspofungin. Pharmacokinetic assessment of caspofungin concentrations in cerebrospinal fluid showed that exposure was adequate in the presence of a high systemic exposure. In complex cases of neonatal Candida infections involving medical devices, the addition of caspofungin might be beneficial.

AB - Invasive Candida infections associated with medical devices are very difficult to cure without device removal. We present a case of neonatal cerebrospinal fluid shunt-associated Candida meningitis, in which removal of the device was precluded, that was successfully treated with caspofungin. Pharmacokinetic assessment of caspofungin concentrations in cerebrospinal fluid showed that exposure was adequate in the presence of a high systemic exposure. In complex cases of neonatal Candida infections involving medical devices, the addition of caspofungin might be beneficial.

KW - Antifungal Agents/therapeutic use

KW - Candida albicans/drug effects

KW - Candidiasis/drug therapy

KW - Caspofungin

KW - Cerebrospinal Fluid Shunts/adverse effects

KW - Echinocandins/therapeutic use

KW - Humans

KW - Infant, Newborn

KW - Infant, Premature

KW - Lipopeptides

KW - Male

KW - Treatment Outcome

U2 - 10.1128/AAC.02085-12

DO - 10.1128/AAC.02085-12

M3 - Article

C2 - 23439643

SN - 0066-4804

VL - 57

SP - 2391

EP - 2393

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 5

ER -

Favorable outcome of neonatal cerebrospinal fluid shunt-associated Candida meningitis with caspofungin

Abstract

Keywords

Access to Document

Fingerprint

Cite this